An unexpected link between angiotensinogen and thrombin

Wang Y, Ragg H (2011)
FEBS Letters 585(14): 2395-2399.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Angiotensinogen is well known as source protein for a group of potent vasoactive hormones, however, a discrete biochemical activity of the angiotensinogen body is not known. Here we investigated angiotensinogen from the lamprey Lampetra fluviatilis (L. fluviatilis), an early-diverged vertebrate. The recombinantly produced protein showed progressive inhibitory activity towards human alpha-thrombin with a second-order rate constant of 2.6 x 10(4) M(-1) min(-1). Heparin enhanced the reaction rate > 800-fold with a bell-shaped dose-response curve and a stoichiometry of inhibition (SI) of 1.3, revealing lamprey angiotensinogen as an effective a-thrombin inhibitor. Genomic, biochemical, and protein sequence data indicate that angiotensinogen and heparin cofactor II (HCII) originated from a common ancestral thrombin antagonist, thus providing insight into an early stage of thrombin control. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Stichworte
Blood coagulation; Angiotensin(ogen); Heparin cofactor II; Serpin; Thrombin
Erscheinungsjahr
2011
Zeitschriftentitel
FEBS Letters
Band
585
Ausgabe
14
Seite(n)
2395-2399
ISSN
0014-5793
Page URI
https://pub.uni-bielefeld.de/record/2307100

Zitieren

Wang Y, Ragg H. An unexpected link between angiotensinogen and thrombin. FEBS Letters. 2011;585(14):2395-2399.
Wang, Y., & Ragg, H. (2011). An unexpected link between angiotensinogen and thrombin. FEBS Letters, 585(14), 2395-2399. doi:10.1016/j.febslet.2011.06.021
Wang, Y., and Ragg, H. (2011). An unexpected link between angiotensinogen and thrombin. FEBS Letters 585, 2395-2399.
Wang, Y., & Ragg, H., 2011. An unexpected link between angiotensinogen and thrombin. FEBS Letters, 585(14), p 2395-2399.
Y. Wang and H. Ragg, “An unexpected link between angiotensinogen and thrombin”, FEBS Letters, vol. 585, 2011, pp. 2395-2399.
Wang, Y., Ragg, H.: An unexpected link between angiotensinogen and thrombin. FEBS Letters. 585, 2395-2399 (2011).
Wang, Yunjie, and Ragg, Hermann. “An unexpected link between angiotensinogen and thrombin”. FEBS Letters 585.14 (2011): 2395-2399.

8 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
Yan Y, Zhou A, Carrell RW, Read RJ., J Biol Chem 294(7), 2019
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Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism.
Wei H, Cai H, Wu J, Wei Z, Zhang F, Huang X, Ma L, Feng L, Zhang R, Wang Y, Ragg H, Zheng Y, Zhou A., J Biol Chem 291(48), 2016
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Kumar A, Bhandari A, Sarde SJ, Goswami C., Immunobiology 219(9), 2014
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Fournier D, Luft FC, Bader M, Ganten D, Andrade-Navarro MA., J Mol Med (Berl) 90(5), 2012
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