An unexpected link between angiotensinogen and thrombin

Wang Y, Ragg H (2011)
FEBS Letters 585(14): 2395-2399.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
DOI
Autor*in
Wang, YunjieUniBi; Ragg, HermannUniBi
Einrichtung
Centrum für Biotechnologie > Arbeitsgruppe H. Ragg
Technische Fakultät > AG Zelluläre Genetik
Centrum für Biotechnologie > Institut für Biochemie und Biotechnik
Abstract / Bemerkung
Angiotensinogen is well known as source protein for a group of potent vasoactive hormones, however, a discrete biochemical activity of the angiotensinogen body is not known. Here we investigated angiotensinogen from the lamprey Lampetra fluviatilis (L. fluviatilis), an early-diverged vertebrate. The recombinantly produced protein showed progressive inhibitory activity towards human alpha-thrombin with a second-order rate constant of 2.6 x 10(4) M(-1) min(-1). Heparin enhanced the reaction rate > 800-fold with a bell-shaped dose-response curve and a stoichiometry of inhibition (SI) of 1.3, revealing lamprey angiotensinogen as an effective a-thrombin inhibitor. Genomic, biochemical, and protein sequence data indicate that angiotensinogen and heparin cofactor II (HCII) originated from a common ancestral thrombin antagonist, thus providing insight into an early stage of thrombin control. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Stichworte
Blood coagulation; Angiotensin(ogen); Heparin cofactor II; Serpin; Thrombin
Erscheinungsjahr
2011
Zeitschriftentitel
FEBS Letters
Band
585
Ausgabe
14
Seite(n)
2395-2399
ISSN
0014-5793
Page URI
https://pub.uni-bielefeld.de/record/2307100

Zitieren

Wang Y, Ragg H. An unexpected link between angiotensinogen and thrombin. FEBS Letters. 2011;585(14):2395-2399.
Wang, Y., & Ragg, H. (2011). An unexpected link between angiotensinogen and thrombin. FEBS Letters, 585(14), 2395-2399. https://doi.org/10.1016/j.febslet.2011.06.021
Wang, Yunjie, and Ragg, Hermann. 2011. “An unexpected link between angiotensinogen and thrombin”. FEBS Letters 585 (14): 2395-2399.
Wang, Y., and Ragg, H. (2011). An unexpected link between angiotensinogen and thrombin. FEBS Letters 585, 2395-2399.
Wang, Y., & Ragg, H., 2011. An unexpected link between angiotensinogen and thrombin. FEBS Letters, 585(14), p 2395-2399.
Y. Wang and H. Ragg, “An unexpected link between angiotensinogen and thrombin”, FEBS Letters, vol. 585, 2011, pp. 2395-2399.
Wang, Y., Ragg, H.: An unexpected link between angiotensinogen and thrombin. FEBS Letters. 585, 2395-2399 (2011).
Wang, Yunjie, and Ragg, Hermann. “An unexpected link between angiotensinogen and thrombin”. FEBS Letters 585.14 (2011): 2395-2399.

8 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
Yan Y, Zhou A, Carrell RW, Read RJ., J Biol Chem 294(7), 2019
PMID: 30563843
Molecular and evolutionary perspectives of the renin-angiotensin system from lamprey.
Wong MKS, Takei Y., Gen Comp Endocrinol 257(), 2018
PMID: 28161438
Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism.
Wei H, Cai H, Wu J, Wei Z, Zhang F, Huang X, Ma L, Feng L, Zhang R, Wang Y, Ragg H, Zheng Y, Zhou A., J Biol Chem 291(48), 2016
PMID: 27681598
Bayesian phylogeny analysis of vertebrate serpins illustrates evolutionary conservation of the intron and indels based six groups classification system from lampreys for ∼500 MY.
Kumar A., PeerJ 3(), 2015
PMID: 26157611
Revising angiotensinogen from phylogenetic and genetic variants perspectives.
Kumar A, Sarde SJ, Bhandari A., Biochem Biophys Res Commun 446(2), 2014
PMID: 24631685
Origin of serpin-mediated regulation of coagulation and blood pressure.
Wang Y, Köster K, Lummer M, Ragg H., PLoS One 9(5), 2014
PMID: 24840053
Genetic variants and evolutionary analyses of heparin cofactor II.
Kumar A, Bhandari A, Sarde SJ, Goswami C., Immunobiology 219(9), 2014
PMID: 24950623
Emergence and evolution of the renin-angiotensin-aldosterone system.
Fournier D, Luft FC, Bader M, Ganten D, Andrade-Navarro MA., J Mol Med (Berl) 90(5), 2012
PMID: 22527880

28 References

Daten bereitgestellt von Europe PubMed Central.

Renin-angiotensin system revisited.
Fyhrquist F, Saijonmaa O., J. Intern. Med. 264(3), 2008
PMID: 18793332
Angiotensin II revisited: new roles in inflammation, immunology and aging.
Benigni A, Cassis P, Remuzzi G., EMBO Mol Med 2(7), 2010
PMID: 20597104
A redox switch in angiotensinogen modulates angiotensin release.
Zhou A, Carrell RW, Murphy MP, Wei Z, Yan Y, Stanley PL, Stein PE, Broughton Pipkin F, Read RJ., Nature 468(7320), 2010
PMID: 20927107
Molecular basis of human hypertension: role of angiotensinogen.
Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM., Cell 71(1), 1992
PMID: 1394429
Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family.
Doolittle RF., Science 222(4622), 1983
PMID: 6604942
Control of the coagulation system by serpins. Getting by with a little help from glycosaminoglycans.
Pike RN, Buckle AM, le Bonniec BF, Church FC., FEBS J. 272(19), 2005
PMID: 16176258
Activation of heparin cofactor II by dermatan sulfate.
Tollefsen DM, Pestka CA, Monafo WJ., J. Biol. Chem. 258(11), 1983
PMID: 6687888
On the activation of human leuserpin-2, a thrombin inhibitor, by glycosaminoglycans.
Ragg H, Ulshofer T, Gerewitz J., J. Biol. Chem. 265(9), 1990
PMID: 2318889
Shape-shifting serpins--advantages of a mobile mechanism.
Huntington JA., Trends Biochem. Sci. 31(8), 2006
PMID: 16820297
Heparin cofactor II modulates the response to vascular injury.
Tollefsen DM., Arterioscler. Thromb. Vasc. Biol. 27(3), 2006
PMID: 17194895
Heparin cofactor II as a novel vascular protective factor against atherosclerosis.
Aihara K, Azuma H, Akaike M, Sata M, Matsumoto T., J. Atheroscler. Thromb. 16(5), 2009
PMID: 19729870
Serpin structure, mechanism, and function.
Gettins PG., Chem. Rev. 102(12), 2002
PMID: 12475206
Ovalbumin and angiotensinogen lack serpin S-R conformational change.
Stein PE, Tewkesbury DA, Carrell RW., Biochem. J. 262(1), 1989
PMID: 2818556
Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes.
Ragg H, Kumar A, Koster K, Bentele C, Wang Y, Frese MA, Prib N, Kruger O., BMC Evol. Biol. 9(), 2009
PMID: 19698129
Vertebrate serpins: construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses.
Ragg H, Lokot T, Kamp PB, Atchley WR, Dress A., Mol. Biol. Evol. 18(4), 2001
PMID: 11264410
Characterization of a native angiotensin from an anciently diverged serine protease inhibitor in lamprey.
Wong MK, Takei Y., J. Endocrinol. 209(1), 2011
PMID: 21220408
450 million years of hemostasis.
Davidson CJ, Tuddenham EG, McVey JH., J. Thromb. Haemost. 1(7), 2003
PMID: 12871284
Genomic evidence for a simpler clotting scheme in jawless vertebrates.
Doolittle RF, Jiang Y, Nand J., J. Mol. Evol. 66(2), 2008
PMID: 18283387
Inhibition of furin by serpin Spn4A from Drosophila melanogaster.
Oley M, Letzel MC, Ragg H., FEBS Lett. 577(1-2), 2004
PMID: 15527779
The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families.
Bruning M, Lummer M, Bentele C, Smolenaars MM, Rodenburg KW, Ragg H., Biochem. J. 401(1), 2007
PMID: 16989645
Reformable intramolecular cross-linking of the N-terminal domain of heparin cofactor II: effects on enzyme inhibition.
Brinkmeyer S, Eckert R, Ragg H., Eur. J. Biochem. 271(21), 2004
PMID: 15511233
Vascular dermatan sulfate and heparin cofactor II.
Tollefsen DM., Prog Mol Biol Transl Sci 93(), 2010
PMID: 20807652
Physicochemical aspects of heparin cofactor II.
Pratt CW, Whinna HC, Meade JB, Treanor RE, Church FC., Ann. N. Y. Acad. Sci. 556(), 1989
PMID: 2660681
Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa.
Huang X, Dementiev A, Olson ST, Gettins PG., J. Biol. Chem. 285(26), 2010
PMID: 20427285
Thrombin as procoagulant and anticoagulant.
Di Cera E., J. Thromb. Haemost. 5 Suppl 1(), 2007
PMID: 17635727
Activation of the newly discovered cyclostome renin-angiotensin system in the river lamprey Lampetra fluviatilis.
Brown JA, Cobb CS, Frankling SC, Rankin JC., J. Exp. Biol. 208(Pt 2), 2005
PMID: 15634842
Phylogenetic analyses of amino acid variation in the serpin proteins.
Atchley WR, Lokot T, Wollenberg K, Dress A, Ragg H., Mol. Biol. Evol. 18(8), 2001
PMID: 11470841
On the size of the active site in proteases. I. Papain.
Schechter I, Berger A., Biochem. Biophys. Res. Commun. 27(2), 1967
PMID: 6035483
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 21722639
PubMed | Europe PMC

Suchen in

Google Scholar