Spotlight on post-transcriptional control in the circadian system

Staiger D, Köster T (2011)
Cellular and Molecular Life Sciences 68(1): 71-83.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
An endogenous timing mechanism, the circadian clock, causes rhythmic expression of a considerable fraction of the genome of most organisms to optimally align physiology and behavior with their environment. Circadian clocks are self-sustained oscillators primarily based on transcriptional feedback loops and post-translational modification of clock proteins. It is increasingly becoming clear that regulation at the RNA level strongly impacts the cellular circadian transcriptome and proteome as well as the oscillator mechanism itself. This review focuses on posttranscriptional events, discussing RNA-binding proteins that, by influencing the timing of pre-mRNA splicing, polyadenylation and RNA decay, shape rhythmic expression profiles. Furthermore, recent findings on the contribution of microRNAs to orchestrating circadian rhythms are summarized.
Stichworte
Circadian clock; Splicing; Post-transcriptional; miRNA; RNA; RNA-binding proteins; decay
Erscheinungsjahr
2011
Zeitschriftentitel
Cellular and Molecular Life Sciences
Band
68
Ausgabe
1
Seite(n)
71-83
ISSN
1420-682X
eISSN
1420-9071
Page URI
https://pub.uni-bielefeld.de/record/2003474

Zitieren

Staiger D, Köster T. Spotlight on post-transcriptional control in the circadian system. Cellular and Molecular Life Sciences. 2011;68(1):71-83.
Staiger, D., & Köster, T. (2011). Spotlight on post-transcriptional control in the circadian system. Cellular and Molecular Life Sciences, 68(1), 71-83. doi:10.1007/s00018-010-0513-5
Staiger, D., and Köster, T. (2011). Spotlight on post-transcriptional control in the circadian system. Cellular and Molecular Life Sciences 68, 71-83.
Staiger, D., & Köster, T., 2011. Spotlight on post-transcriptional control in the circadian system. Cellular and Molecular Life Sciences, 68(1), p 71-83.
D. Staiger and T. Köster, “Spotlight on post-transcriptional control in the circadian system”, Cellular and Molecular Life Sciences, vol. 68, 2011, pp. 71-83.
Staiger, D., Köster, T.: Spotlight on post-transcriptional control in the circadian system. Cellular and Molecular Life Sciences. 68, 71-83 (2011).
Staiger, Dorothee, and Köster, Tino. “Spotlight on post-transcriptional control in the circadian system”. Cellular and Molecular Life Sciences 68.1 (2011): 71-83.

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