HMGB6 from Arabidopsis thaliana specifies a novel type of plant chromosomal HMGB protein

Grasser KD, Grill S, Duroux M, Launholt D, Thomsen MS, Nielsen BV, Nielsen HK, Merkle T (2004)
Biochemistry 43(5): 1309-1314.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Grasser, Klaus D; Grill, Simon; Duroux, Meg; Launholt, Dorte; Thomsen, Malene S; Nielsen, Birthe V; Nielsen, Hanne K; Merkle, ThomasUniBi
Abstract / Bemerkung
The high-mobility group (HMG) proteins of the HMGB family are chromatin-associated proteins that act as architectural factors in various nucleoprotein structures, which regulate DNA-dependent processes such as transcription and recombination. Database analyses revealed that in addition to the previously identified HMGB1-HMGB5 proteins, the Arabidopsis genome encodes at least three other family members having the typical overall structure of a central HMG-box DNA binding domain, which is flanked by basic and acidic regions. These novel HMGB proteins display some structural differences, when compared to HMGB1-HMGB5. Therefore, a representative of the identified proteins, now termed HMGB6, was further analyzed. The HMGB6 protein of approximately 27 kDa is the largest plant HMGB protein identified so far. This is essentially due to its unusually extended N-terminal domain of 109 amino acid residues. Subcellular localization experiments demonstrate that it is a nuclear protein. According to CD measurements, HMGB6 has an alpha-helical HMG-box domain. HMGB6 can bind DNA structure-specifically, and it is a substrate for the protein kinase CK2alpha. Because of these features, HMGB6, and presumably its relatives, can be considered members of the plant HMGB protein family. Hence, eight different chromosomal HMGB proteins are expressed in Arabidopsis, and they may serve specialized architectural functions assisting various DNA-dependent processes.
Stichworte
Casein Kinase II; Cell Nucleus; Chromosomes; Sequence Homology; Amino Acid; Sequence Analysis; Protein; Sequence Alignment; Recombinant Proteins; Protein-Serine-Threonine Kinases; Structure-Activity Relationship; Phosphorylation; Nuclear Proteins; Molecular Sequence Data; HMGB Proteins; Plant; DNA-Binding Proteins; Arabidopsis Proteins; Amino Acid Sequence
Erscheinungsjahr
2004
Zeitschriftentitel
Biochemistry
Band
43
Ausgabe
5
Seite(n)
1309-1314
ISSN
0006-2960
eISSN
1520-4995
Page URI
https://pub.uni-bielefeld.de/record/1996206

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Grasser KD, Grill S, Duroux M, et al. HMGB6 from Arabidopsis thaliana specifies a novel type of plant chromosomal HMGB protein. Biochemistry. 2004;43(5):1309-1314.
Grasser, K. D., Grill, S., Duroux, M., Launholt, D., Thomsen, M. S., Nielsen, B. V., Nielsen, H. K., et al. (2004). HMGB6 from Arabidopsis thaliana specifies a novel type of plant chromosomal HMGB protein. Biochemistry, 43(5), 1309-1314. https://doi.org/10.1021/bi035931c
Grasser, Klaus D, Grill, Simon, Duroux, Meg, Launholt, Dorte, Thomsen, Malene S, Nielsen, Birthe V, Nielsen, Hanne K, and Merkle, Thomas. 2004. “HMGB6 from Arabidopsis thaliana specifies a novel type of plant chromosomal HMGB protein”. Biochemistry 43 (5): 1309-1314.
Grasser, K. D., Grill, S., Duroux, M., Launholt, D., Thomsen, M. S., Nielsen, B. V., Nielsen, H. K., and Merkle, T. (2004). HMGB6 from Arabidopsis thaliana specifies a novel type of plant chromosomal HMGB protein. Biochemistry 43, 1309-1314.
Grasser, K.D., et al., 2004. HMGB6 from Arabidopsis thaliana specifies a novel type of plant chromosomal HMGB protein. Biochemistry, 43(5), p 1309-1314.
K.D. Grasser, et al., “HMGB6 from Arabidopsis thaliana specifies a novel type of plant chromosomal HMGB protein”, Biochemistry, vol. 43, 2004, pp. 1309-1314.
Grasser, K.D., Grill, S., Duroux, M., Launholt, D., Thomsen, M.S., Nielsen, B.V., Nielsen, H.K., Merkle, T.: HMGB6 from Arabidopsis thaliana specifies a novel type of plant chromosomal HMGB protein. Biochemistry. 43, 1309-1314 (2004).
Grasser, Klaus D, Grill, Simon, Duroux, Meg, Launholt, Dorte, Thomsen, Malene S, Nielsen, Birthe V, Nielsen, Hanne K, and Merkle, Thomas. “HMGB6 from Arabidopsis thaliana specifies a novel type of plant chromosomal HMGB protein”. Biochemistry 43.5 (2004): 1309-1314.

15 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

C-terminal extension of calmodulin-like 3 protein from Oryza sativa L.: interaction with a high mobility group target protein.
Chinpongpanich A, Phean-O-Pas S, Thongchuang M, Qu LJ, Buaboocha T., Acta Biochim Biophys Sin (Shanghai) 47(11), 2015
PMID: 26423116
HMGB1 in health and disease.
Kang R, Chen R, Zhang Q, Hou W, Wu S, Cao L, Huang J, Yu Y, Fan XG, Yan Z, Sun X, Wang H, Wang Q, Tsung A, Billiar TR, Zeh HJ, Lotze MT, Tang D., Mol Aspects Med 40(), 2014
PMID: 25010388
Unexpected mobility of plant chromatin-associated HMGB proteins.
Merkle T, Grasser KD., Plant Signal Behav 6(6), 2011
PMID: 21543902
The plant-specific family of DNA-binding proteins containing three HMG-box domains interacts with mitotic and meiotic chromosomes.
Pedersen DS, Coppens F, Ma L, Antosch M, Marktl B, Merkle T, Beemster GT, Houben A, Grasser KD., New Phytol 192(3), 2011
PMID: 21781122
A member of the highly conserved FWL (tomato FW2.2-like) gene family is essential for soybean nodule organogenesis.
Libault M, Zhang XC, Govindarajulu M, Qiu J, Ong YT, Brechenmacher L, Berg RH, Hurley-Sommer A, Taylor CG, Stacey G., Plant J 62(5), 2010
PMID: 20230508
Nucleocytoplasmic distribution of the Arabidopsis chromatin-associated HMGB2/3 and HMGB4 proteins.
Pedersen DS, Merkle T, Marktl B, Lildballe DL, Antosch M, Bergmann T, Tönsing K, Anselmetti D, Grasser KD., Plant Physiol 154(4), 2010
PMID: 20940346
Chromosomal high mobility group (HMG) proteins of the HMGB-type occurring in the moss Physcomitrella patens.
Kiilerich B, Stemmer C, Merkle T, Launholt D, Gorr G, Grasser KD., Gene 407(1-2), 2008
PMID: 17980517
The expression level of the chromatin-associated HMGB1 protein influences growth, stress tolerance, and transcriptome in Arabidopsis.
Lildballe DL, Pedersen DS, Kalamajka R, Emmersen J, Houben A, Grasser KD., J Mol Biol 384(1), 2008
PMID: 18822296
Retrotransposon and gene activation in wheat in response to mycotoxigenic and non-mycotoxigenic-associated Fusarium stress.
Ansari KI, Walter S, Brennan JM, Lemmens M, Kessans S, McGahern A, Egan D, Doohan FM., Theor Appl Genet 114(5), 2007
PMID: 17256175
Overlapping expression patterns among the genes encoding Arabidopsis chromosomal high mobility group (HMG) proteins.
Launholt D, Grønlund JT, Nielsen HK, Grasser KD., FEBS Lett 581(6), 2007
PMID: 17316617
The Arabidopsis genome encodes structurally and functionally diverse HMGB-type proteins.
Grasser M, Lentz A, Lichota J, Merkle T, Grasser KD., J Mol Biol 358(3), 2006
PMID: 16563436

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