Intron creation and DNA repair

Ragg H (2011)
Cell. Mol. Life Sci. 68(2): 235-242.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
The genesis of the exon-intron patterns of eukaryotic genes persists as one of the most enigmatic questions in molecular genetics. In particular, the origin and mechanisms responsible for creation of spliceosomal introns have remained controversial. Now the issue appears to have taken a turn. The formation of novel introns in eukaryotes, including some vertebrate lineages, is not as rare as commonly assumed. Moreover, introns appear to have been gained in parallel at closely spaced sites and even repeatedly at the same position. Based on these discoveries, novel hypotheses of intron creation have been developed. The new concepts posit that DNA repair processes are a major source of intron formation. Here, after summarizing the current views of intron gain mechanisms, I review findings in support of the DNA repair hypothesis that provides a global mechanistic scenario for intron creation. Some implications on our perception of the mosaic structure of eukaryotic genes are also discussed.
Stichworte
Intron creation; DNA repair; Splicing
Erscheinungsjahr
2011
Zeitschriftentitel
Cell. Mol. Life Sci.
Band
68
Ausgabe
2
Seite(n)
235-242
ISSN
1420-682X
eISSN
1420-9071
Page URI
https://pub.uni-bielefeld.de/record/1948655

Zitieren

Ragg H. Intron creation and DNA repair. Cell. Mol. Life Sci. 2011;68(2):235-242.
Ragg, H. (2011). Intron creation and DNA repair. Cell. Mol. Life Sci., 68(2), 235-242. https://doi.org/10.1007/s00018-010-0532-2
Ragg, H. (2011). Intron creation and DNA repair. Cell. Mol. Life Sci. 68, 235-242.
Ragg, H., 2011. Intron creation and DNA repair. Cell. Mol. Life Sci., 68(2), p 235-242.
H. Ragg, “Intron creation and DNA repair”, Cell. Mol. Life Sci., vol. 68, 2011, pp. 235-242.
Ragg, H.: Intron creation and DNA repair. Cell. Mol. Life Sci. 68, 235-242 (2011).
Ragg, Hermann. “Intron creation and DNA repair”. Cell. Mol. Life Sci. 68.2 (2011): 235-242.

7 Zitationen in Europe PMC

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