Emerging Corynebacterium glutamicum systems biology
Wendisch VF, Bott M, Kalinowski J, Oldiges M, Wiechert W (2006)
Journal of Biotechnology 124(1): 74-92.
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| Veröffentlicht | Englisch
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Einrichtung
Abstract / Bemerkung
Corynebacterium glutamicum is widely used for the biotechnological production of amino acids. Amino acid producing strains have been improved classically by mutagenesis and screening as well as in a rational manner using recombinant DNA technology. Metabolic flux analysis may be viewed as the first systems approach to C glutamicum physiology since it combines isotope labeling data with metabolic network models of the biosynthetic and central metabolic pathways. However, only the complete genome sequence of C. glutamicum and post-genomics methods such as transcriptomics and proteomics have allowed characterizing metabolic and regulatory properties of this bacterium on a truly global level. Besides transcriptomics, and proteomics, metabolomics, and modeling approaches have now been established. Systems biology, which uses systematic genomic, proteomic and metabolomic technologies with the final aim of constructing comprehensive and predictive models of complex biological systems, is emerging for C. glutamicum. We will present current developments that advanced our insight into fundamental biology of C. glutamicum and that in the future will enable novel biotechnological applications for the improvement of amino acid production. (c) 2005 Elsevier B.V. All rights reserved.
Stichworte
l-lysine production;
sensor reactor approach;
complete genome sequence;
mathematical modeling;
metabolic flux analysis;
metabolite profiling;
metabolomics;
pyruvate-carboxylase;
saccharomyces-cerevisiae;
escherichia-coli;
mass-spectrometry;
in-vivo kinetics;
white biotechnology;
systems biology;
corynebacterium glutamicum;
amino acid production;
genomics;
strain development;
transcriptomics;
proteomics;
DNA microarray;
metabolic flux analysis;
amino-acid production
Erscheinungsjahr
2006
Zeitschriftentitel
Journal of Biotechnology
Band
124
Ausgabe
1
Seite(n)
74-92
ISSN
0168-1656
Page URI
https://pub.uni-bielefeld.de/record/1895365
Zitieren
Wendisch VF, Bott M, Kalinowski J, Oldiges M, Wiechert W. Emerging Corynebacterium glutamicum systems biology. Journal of Biotechnology. 2006;124(1):74-92.
Wendisch, V. F., Bott, M., Kalinowski, J., Oldiges, M., & Wiechert, W. (2006). Emerging Corynebacterium glutamicum systems biology. Journal of Biotechnology, 124(1), 74-92. https://doi.org/10.1016/j.jbiotec.2005.12.002
Wendisch, Volker F., Bott, M., Kalinowski, Jörn, Oldiges, M., and Wiechert, W. 2006. “Emerging Corynebacterium glutamicum systems biology”. Journal of Biotechnology 124 (1): 74-92.
Wendisch, V. F., Bott, M., Kalinowski, J., Oldiges, M., and Wiechert, W. (2006). Emerging Corynebacterium glutamicum systems biology. Journal of Biotechnology 124, 74-92.
Wendisch, V.F., et al., 2006. Emerging Corynebacterium glutamicum systems biology. Journal of Biotechnology, 124(1), p 74-92.
V.F. Wendisch, et al., “Emerging Corynebacterium glutamicum systems biology”, Journal of Biotechnology, vol. 124, 2006, pp. 74-92.
Wendisch, V.F., Bott, M., Kalinowski, J., Oldiges, M., Wiechert, W.: Emerging Corynebacterium glutamicum systems biology. Journal of Biotechnology. 124, 74-92 (2006).
Wendisch, Volker F., Bott, M., Kalinowski, Jörn, Oldiges, M., and Wiechert, W. “Emerging Corynebacterium glutamicum systems biology”. Journal of Biotechnology 124.1 (2006): 74-92.
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