Comparative Analysis of Plasmids in the Genus Listeria

Kuenne C, Voget S, Pischimarov J, Oehm S, Goesmann A, Daniel R, Hain T, Chakraborty T (2010)
PLOS ONE 5(9): e12511.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Autor/in
; ; ; ; ; ; ;
Abstract / Bemerkung
Background: We sequenced four plasmids of the genus Listeria, including two novel plasmids from L. monocytogenes serotype 1/2c and 7 strains as well as one from the species L. grayi. A comparative analysis in conjunction with 10 published Listeria plasmids revealed a common evolutionary background. Principal Findings: All analysed plasmids share a common replicon-type related to theta-replicating plasmid pAMbeta1. Nonetheless plasmids could be broadly divided into two distinct groups based on replicon diversity and the genetic content of the respective plasmid groups. Listeria plasmids are characterized by the presence of a large number of diverse mobile genetic elements and a commonly occurring translesion DNA polymerase both of which have probably contributed to the evolution of these plasmids. We detected small non-coding RNAs on some plasmids that were homologous to those present on the chromosome of L. monocytogenes EGD-e. Multiple genes involved in heavy metal resistance (cadmium, copper, arsenite) as well as multidrug efflux (MDR, SMR, MATE) were detected on all listerial plasmids. These factors promote bacterial growth and survival in the environment and may have been acquired as a result of selective pressure due to the use of disinfectants in food processing environments. MDR efflux pumps have also recently been shown to promote transport of cyclic diadenosine monophosphate (c-di-AMP) as a secreted molecule able to trigger a cytosolic host immune response following infection. Conclusions: The comparative analysis of 14 plasmids of genus Listeria implied the existence of a common ancestor. Ubiquitously-occurring MDR genes on plasmids and their role in listerial infection now deserve further attention.
Erscheinungsjahr
2010
Zeitschriftentitel
PLOS ONE
Band
5
Ausgabe
9
Seite(n)
e12511
ISSN
1932-6203
eISSN
1932-6203
Page URI
https://pub.uni-bielefeld.de/record/1794039

Zitieren

Kuenne C, Voget S, Pischimarov J, et al. Comparative Analysis of Plasmids in the Genus Listeria. PLOS ONE. 2010;5(9):e12511.
Kuenne, C., Voget, S., Pischimarov, J., Oehm, S., Goesmann, A., Daniel, R., Hain, T., et al. (2010). Comparative Analysis of Plasmids in the Genus Listeria. PLOS ONE, 5(9), e12511. doi:10.1371/journal.pone.0012511
Kuenne, C., Voget, S., Pischimarov, J., Oehm, S., Goesmann, A., Daniel, R., Hain, T., and Chakraborty, T. (2010). Comparative Analysis of Plasmids in the Genus Listeria. PLOS ONE 5, e12511.
Kuenne, C., et al., 2010. Comparative Analysis of Plasmids in the Genus Listeria. PLOS ONE, 5(9), p e12511.
C. Kuenne, et al., “Comparative Analysis of Plasmids in the Genus Listeria”, PLOS ONE, vol. 5, 2010, pp. e12511.
Kuenne, C., Voget, S., Pischimarov, J., Oehm, S., Goesmann, A., Daniel, R., Hain, T., Chakraborty, T.: Comparative Analysis of Plasmids in the Genus Listeria. PLOS ONE. 5, e12511 (2010).
Kuenne, Carsten, Voget, Sonja, Pischimarov, Jordan, Oehm, Sebastian, Goesmann, Alexander, Daniel, Rolf, Hain, Torsten, and Chakraborty, Trinad. “Comparative Analysis of Plasmids in the Genus Listeria”. PLOS ONE 5.9 (2010): e12511.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 20824078
PubMed | Europe PMC

Suchen in

Google Scholar