Ancestry and evolution of a secretory pathway serpin
Kumar A, Ragg H (2008)
BMC Evolutionary Biology 8(1): 250.
Zeitschriftenaufsatz
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Autor*in
Kumar, Abhishek;
Ragg, HermannUniBi
Einrichtung
Abstract / Bemerkung
Background:The serpin (serine protease inhibitor) superfamily constitutes a class of functionally highly diverse proteins usually encompassing several dozens of paralogs in mammals. Though phylogenetic classification of vertebrate serpins into six groups based on gene organisation is well established, the evolutionary roots beyond the fish/tetrapod split are unresolved. The aim of this study was to elucidate the phylogenetic relationships of serpins involved in surveying the secretory pathway routes against uncontrolled proteolytic activity. Results: Here, rare genomic characters are used to show that orthologs of neuroserpin, a prominent representative of vertebrate group 3 serpin genes, exist in early diverging deuterostomes and probably also in cnidarians, indicating that the origin of a mammalian serpin can be traced back far in the history of eumetazoans. A C-terminal address code assigning association with secretory pathway organelles is present in all neuroserpin orthologs, suggesting that supervision of cellular export/import routes by antiproteolytic serpins is an ancient trait, though subtle functional and compartmental specialisations have developed during their evolution. The results also suggest that massive changes in the exon-intron organisation of serpin genes have occurred along the lineage leading to vertebrate neuroserpin, in contrast with the immediately adjacent PDCD10 gene that is linked to its neighbour at least since divergence of echinoderms. The intron distribution pattern of closely adjacent and co-regulated genes thus may experience quite different fates during evolution of metazoans. Conclusion: This study demonstrates that the analysis of microsynteny and other rare characters can provide insight into the intricate family history of metazoan serpins. Serpins with the capacity to defend the main cellular export/import routes against uncontrolled endogenous and/or foreign proteolytic activity represent an ancient trait in eukaryotes that has been maintained continuously in metazoans though subtle changes affecting function and subcellular location have evolved. It is shown that the intron distribution pattern of neuroserpin gene orthologs has undergone substantial rearrangements during metazoan evolution.
Erscheinungsjahr
2008
Zeitschriftentitel
BMC Evolutionary Biology
Band
8
Ausgabe
1
Art.-Nr.
250
ISSN
1471-2148
Page URI
https://pub.uni-bielefeld.de/record/1783341
Zitieren
Kumar A, Ragg H. Ancestry and evolution of a secretory pathway serpin. BMC Evolutionary Biology. 2008;8(1): 250.
Kumar, A., & Ragg, H. (2008). Ancestry and evolution of a secretory pathway serpin. BMC Evolutionary Biology, 8(1), 250. https://doi.org/10.1186/1471-2148-8-250
Kumar, Abhishek, and Ragg, Hermann. 2008. “Ancestry and evolution of a secretory pathway serpin”. BMC Evolutionary Biology 8 (1): 250.
Kumar, A., and Ragg, H. (2008). Ancestry and evolution of a secretory pathway serpin. BMC Evolutionary Biology 8:250.
Kumar, A., & Ragg, H., 2008. Ancestry and evolution of a secretory pathway serpin. BMC Evolutionary Biology, 8(1): 250.
A. Kumar and H. Ragg, “Ancestry and evolution of a secretory pathway serpin”, BMC Evolutionary Biology, vol. 8, 2008, : 250.
Kumar, A., Ragg, H.: Ancestry and evolution of a secretory pathway serpin. BMC Evolutionary Biology. 8, : 250 (2008).
Kumar, Abhishek, and Ragg, Hermann. “Ancestry and evolution of a secretory pathway serpin”. BMC Evolutionary Biology 8.1 (2008): 250.
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2019-09-06T08:48:51Z
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Daten bereitgestellt von European Bioinformatics Institute (EBI)
17 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1).
Kumar A, Bhandari A, Sarde SJ, Goswami C., Sci Rep 7(1), 2017
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Kumar A, Bhandari A, Sarde SJ, Goswami C., Sci Rep 7(1), 2017
PMID: 28871169
Data on the evolutionary history of the V(D)J recombination-activating protein 1 - RAG1 coupled with sequence and variant analyses.
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PMID: 27284568
Kumar A, Bhandari A, Sarde SJ, Muppavarapu S, Tandon R., Data Brief 8(), 2016
PMID: 27284568
The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans.
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PMID: 25786854
Silverman RM, Cummings EE, O'Reilly LP, Miedel MT, Silverman GA, Luke CJ, Perlmutter DH, Pak SC., Genetics 200(1), 2015
PMID: 25786854
Understanding V(D)J recombination initiator RAG1 gene using molecular phylogenetic and genetic variant analyses and upgrading missense and non-coding variants of clinical importance.
Kumar A, Bhandari A, Sarde SJ, Muppavarapu S, Tandon R., Biochem Biophys Res Commun 462(4), 2015
PMID: 25976673
Kumar A, Bhandari A, Sarde SJ, Muppavarapu S, Tandon R., Biochem Biophys Res Commun 462(4), 2015
PMID: 25976673
Sequencing, De Novo assembly and annotation of the Colorado Potato Beetle, Leptinotarsa decemlineata, Transcriptome.
Kumar A, Congiu L, Lindström L, Piiroinen S, Vidotto M, Grapputo A., PLoS One 9(1), 2014
PMID: 24465841
Kumar A, Congiu L, Lindström L, Piiroinen S, Vidotto M, Grapputo A., PLoS One 9(1), 2014
PMID: 24465841
Revising angiotensinogen from phylogenetic and genetic variants perspectives.
Kumar A, Sarde SJ, Bhandari A., Biochem Biophys Res Commun 446(2), 2014
PMID: 24631685
Kumar A, Sarde SJ, Bhandari A., Biochem Biophys Res Commun 446(2), 2014
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Molecular phylogeny of C1 inhibitor depicts two immunoglobulin-like domains fusion in fishes and ray-finned fishes specific intron insertion after separation from zebrafish.
Kumar A, Bhandari A, Sarde SJ, Goswami C., Biochem Biophys Res Commun 450(1), 2014
PMID: 24878530
Kumar A, Bhandari A, Sarde SJ, Goswami C., Biochem Biophys Res Commun 450(1), 2014
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Genetic variants and evolutionary analyses of heparin cofactor II.
Kumar A, Bhandari A, Sarde SJ, Goswami C., Immunobiology 219(9), 2014
PMID: 24950623
Kumar A, Bhandari A, Sarde SJ, Goswami C., Immunobiology 219(9), 2014
PMID: 24950623
Urochordate serpins are Classified into Six Groups Encoded by Exon-Intron Structures, Microsynteny and Bayesian Phylogenetic Analyses.
Kumar A, Bhandari A., J Genomics 2(), 2014
PMID: 25184006
Kumar A, Bhandari A., J Genomics 2(), 2014
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Surveying genetic variants and molecular phylogeny of cerebral cavernous malformation gene, CCM3/PDCD10.
Kumar A, Bhandari A, Goswami C., Biochem Biophys Res Commun 455(1-2), 2014
PMID: 25451273
Kumar A, Bhandari A, Goswami C., Biochem Biophys Res Commun 455(1-2), 2014
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Characterization of bud emergence 46 (BEM46) protein: sequence, structural, phylogenetic and subcellular localization analyses.
Kumar A, Kollath-Leiß K, Kempken F., Biochem Biophys Res Commun 438(3), 2013
PMID: 23916612
Kumar A, Kollath-Leiß K, Kempken F., Biochem Biophys Res Commun 438(3), 2013
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Sequence, phylogenetic and variant analyses of antithrombin III.
Kumar A, Bhandari A, Sarde SJ, Goswami C., Biochem Biophys Res Commun 440(4), 2013
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Kumar A, Bhandari A, Sarde SJ, Goswami C., Biochem Biophys Res Commun 440(4), 2013
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Conservation of tubulin-binding sequences in TRPV1 throughout evolution.
Sardar P, Kumar A, Bhandari A, Goswami C., PLoS One 7(4), 2012
PMID: 22496727
Sardar P, Kumar A, Bhandari A, Goswami C., PLoS One 7(4), 2012
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Origin and evolution of spliceosomal introns.
Rogozin IB, Carmel L, Csuros M, Koonin EV., Biol Direct 7(), 2012
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Spliceosomal intron insertions in genome compacted ray-finned fishes as evident from phylogeny of MC receptors, also supported by a few other GPCRs.
Kumar A, Bhandari A, Sinha R, Goyal P, Grapputo A., PLoS One 6(8), 2011
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Kumar A, Bhandari A, Sinha R, Goyal P, Grapputo A., PLoS One 6(8), 2011
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Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes.
Ragg H, Kumar A, Köster K, Bentele C, Wang Y, Frese MA, Prib N, Krüger O., BMC Evol Biol 9(), 2009
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Ragg H, Kumar A, Köster K, Bentele C, Wang Y, Frese MA, Prib N, Krüger O., BMC Evol Biol 9(), 2009
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Bowes JB, Snyder KA, Segerdell E, Gibb R, Jarabek C, Noumen E, Pollet N, Vize PD., Nucleic Acids Res. 36(Database issue), 2007
PMID: 17984085
Tetraodon genome browser at the French National Sequencing Center – Genoscope
AUTHOR UNKNOWN, 0
AUTHOR UNKNOWN, 0
The UCSC Genome Browser Database: 2008 update.
Karolchik D, Kuhn RM, Baertsch R, Barber GP, Clawson H, Diekhans M, Giardine B, Harte RA, Hinrichs AS, Hsu F, Kober KM, Miller W, Pedersen JS, Pohl A, Raney BJ, Rhead B, Rosenbloom KR, Smith KE, Stanke M, Thakkapallayil A, Trumbower H, Wang T, Zweig AS, Haussler D, Kent WJ., Nucleic Acids Res. 36(Database issue), 2007
PMID: 18086701
Karolchik D, Kuhn RM, Baertsch R, Barber GP, Clawson H, Diekhans M, Giardine B, Harte RA, Hinrichs AS, Hsu F, Kober KM, Miller W, Pedersen JS, Pohl A, Raney BJ, Rhead B, Rosenbloom KR, Smith KE, Stanke M, Thakkapallayil A, Trumbower H, Wang T, Zweig AS, Haussler D, Kent WJ., Nucleic Acids Res. 36(Database issue), 2007
PMID: 18086701
The genome of the sea urchin Strongylocentrotus purpuratus.
Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Belle R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Geneviere AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallbook F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Rottinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R., Science 314(5801), 2006
PMID: 17095691
Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Belle R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Geneviere AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallbook F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Rottinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R., Science 314(5801), 2006
PMID: 17095691
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG., Nucleic Acids Res. 25(24), 1997
PMID: 9396791
Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG., Nucleic Acids Res. 25(24), 1997
PMID: 9396791
GeneDoc: analysis and visualization of genetic variation
AUTHOR UNKNOWN, 1997
AUTHOR UNKNOWN, 1997
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PMID: 18793432
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