Decision making in patients with temporal lobe epilepsy

Labudda K, Frigge K, Horstmann S, Aengenendt J, Woermann FG, Ebner A, Markowitsch HJ, Brand M (2009)
NEUROPSYCHOLOGIA 47(1): 50-58.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Autor/in
; ; ; ; ; ; ;
Abstract / Bemerkung
The mesiotemporal lobe is involved in decision making processes because bilateral amygdala damage can cause impairments in decision making that is mainly based on the processing of emotional feedback. In addition to executive functions, previous studies have suggested the involvement of feedback processing in decision making under risk when explicit information about consequences and their probabilities is provided. In the current study, we investigated whether unilateral mesiotemporal damage, comprising of the hippocampus and/or the amygdala, results in alterations of both kinds of decision making. For this purpose, we preoperatively examined 20 patients with refractory unilateral mesiotemporal lobe epilepsy (TLE) and a comparison group (CG) of 20 healthy volunteers with the Iowa Gambling Task to assess decision making based on feedback processing, the Game of Dice Task to assess decision making under risk, and with a neuropsychological test battery. Results indicate that TLE patients performed normally in decision making under risk, but can exhibit disturbances in decision making on the Iowa Gambling Task. A subgroup analysis revealed that those patients with a preference for the disadvantageous alternatives performed worse on executive subcomponents and had seizure onset at an earlier age in comparison to the patient subgroup without disadvantageous decision making. Furthermore, disadvantageous decision making can emerge in patients with selective hippocampal sclerosis not extended to the amygdala. Thus, our results demonstrate for the first time that presurgical patients with TLE can have selective reductions in decision making and that these deficits can result from hippocampal lesions without structural amygdala abnormalities. (C) 2008 Elsevier Ltd. All rights reserved.
Stichworte
Feedback processing; Hippocampus; Amygdala; Executive functions; Risk; Ambiguity
Erscheinungsjahr
2009
Zeitschriftentitel
NEUROPSYCHOLOGIA
Band
47
Ausgabe
1
Seite(n)
50-58
ISSN
0028-3932
Page URI
https://pub.uni-bielefeld.de/record/1636039

Zitieren

Labudda K, Frigge K, Horstmann S, et al. Decision making in patients with temporal lobe epilepsy. NEUROPSYCHOLOGIA. 2009;47(1):50-58.
Labudda, K., Frigge, K., Horstmann, S., Aengenendt, J., Woermann, F. G., Ebner, A., Markowitsch, H. J., et al. (2009). Decision making in patients with temporal lobe epilepsy. NEUROPSYCHOLOGIA, 47(1), 50-58. doi:10.1016/j.neuropsychologia.2008.08.014
Labudda, K., Frigge, K., Horstmann, S., Aengenendt, J., Woermann, F. G., Ebner, A., Markowitsch, H. J., and Brand, M. (2009). Decision making in patients with temporal lobe epilepsy. NEUROPSYCHOLOGIA 47, 50-58.
Labudda, K., et al., 2009. Decision making in patients with temporal lobe epilepsy. NEUROPSYCHOLOGIA, 47(1), p 50-58.
K. Labudda, et al., “Decision making in patients with temporal lobe epilepsy”, NEUROPSYCHOLOGIA, vol. 47, 2009, pp. 50-58.
Labudda, K., Frigge, K., Horstmann, S., Aengenendt, J., Woermann, F.G., Ebner, A., Markowitsch, H.J., Brand, M.: Decision making in patients with temporal lobe epilepsy. NEUROPSYCHOLOGIA. 47, 50-58 (2009).
Labudda, Kirsten, Frigge, Kristina, Horstmann, Simone, Aengenendt, Joerg, Woermann, Friedrich G., Ebner, Alois, Markowitsch, Hans J., and Brand, Matthias. “Decision making in patients with temporal lobe epilepsy”. NEUROPSYCHOLOGIA 47.1 (2009): 50-58.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 18789345
PubMed | Europe PMC

Suchen in

Google Scholar