A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJL, Kane C, Huebel K, et al. (2009)
NATURE CELL BIOLOGY 11(6): 705-716.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The microRNA pathway has been implicated in the regulation of synaptic protein synthesis and ultimately in dendritic spine morphogenesis, a phenomenon associated with long-lasting forms of memory. However, the particular microRNAs (miRNAs) involved are largely unknown. Here we identify specific miRNAs that function at synapses to control dendritic spine structure by performing a functional screen. One of the identified miRNAs, miR-138, is highly enriched in the brain, localized within dendrites and negatively regulates the size of dendritic spines in rat hippocampal neurons. miR-138 controls the expression of acyl protein thioesterase 1 (APT1), an enzyme regulating the palmitoylation status of proteins that are known to function at the synapse, including the alpha(13) subunits of G proteins (G alpha(13)). RNA-interference-mediated knockdown of APT1 and the expression of membrane-localized G alpha(13) both suppress spine enlargement caused by inhibition of miR-138, suggesting that APT1-regulated depalmitoylation of G alpha(13) might be an important downstream event of miR-138 function. Our results uncover a previously unknown miRNA-dependent mechanism in neurons and demonstrate a previously unrecognized complexity of miRNA-dependent control of dendritic spine morphogenesis.


Siegel G, Obernosterer G, Fiore R, et al. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. NATURE CELL BIOLOGY. 2009;11(6):705-716.
Siegel, G., Obernosterer, G., Fiore, R., Oehmen, M., Bicker, S., Christensen, M., Khudayberdiev, S., et al. (2009). A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. NATURE CELL BIOLOGY, 11(6), 705-716. doi:10.1038/ncb1876
Siegel, G., Obernosterer, G., Fiore, R., Oehmen, M., Bicker, S., Christensen, M., Khudayberdiev, S., Leuschner, P. F., Busch, C. J. L., Kane, C., et al. (2009). A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. NATURE CELL BIOLOGY 11, 705-716.
Siegel, G., et al., 2009. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. NATURE CELL BIOLOGY, 11(6), p 705-716.
G. Siegel, et al., “A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis”, NATURE CELL BIOLOGY, vol. 11, 2009, pp. 705-716.
Siegel, G., Obernosterer, G., Fiore, R., Oehmen, M., Bicker, S., Christensen, M., Khudayberdiev, S., Leuschner, P.F., Busch, C.J.L., Kane, C., Huebel, K., Dekker, F., Hedberg, C., Rengarajan, B., Drepper, C., Waldmann, H., Kauppinen, S., Greenberg, M.E., Draguhn, A., Rehmsmeier, M., Martinez, J., Schratt, G.M.: A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. NATURE CELL BIOLOGY. 11, 705-716 (2009).
Siegel, Gabriele, Obernosterer, Gregor, Fiore, Roberto, Oehmen, Martin, Bicker, Silvia, Christensen, Mette, Khudayberdiev, Sharof, Leuschner, Philipp F., Busch, Clara J. L., Kane, Christina, Huebel, Katja, Dekker, Frank, Hedberg, Christian, Rengarajan, Balamurugan, Drepper, Carsten, Waldmann, Herbert, Kauppinen, Sakari, Greenberg, Michael E., Draguhn, Andreas, Rehmsmeier, Marc, Martinez, Javier, and Schratt, Gerhard M. “A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis”. NATURE CELL BIOLOGY 11.6 (2009): 705-716.

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Tonacci A, Bagnato G, Pandolfo G, Billeci L, Sansone F, Conte R, Gangemi S., J Clin Med 8(1), 2019
PMID: 30646527
Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations.
Li K, Wei Q, Liu FF, Hu F, Xie AJ, Zhu LQ, Liu D., Mol Neurobiol 55(4), 2018
PMID: 28456942
Protein depalmitoylases.
Won SJ, Cheung See Kit M, Martin BR., Crit Rev Biochem Mol Biol 53(1), 2018
PMID: 29239216
The dynamic recruitment of TRBP to neuronal membranes mediates dendritogenesis during development.
Antoniou A, Khudayberdiev S, Idziak A, Bicker S, Jacob R, Schratt G., EMBO Rep 19(3), 2018
PMID: 29263199
Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures.
Azevedo H, Amato Khaled N, Santos P, Bernardi Bertonha F, Moreira-Filho CA., Dis Model Mech 11(1), 2018
PMID: 29196444
NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity.
Rajgor D, Sanderson TM, Amici M, Collingridge GL, Hanley JG., EMBO J 37(11), 2018
PMID: 29712715
Spatiotemporal microRNA profile in peripheral nerve regeneration: miR-138 targets vimentin and inhibits Schwann cell migration and proliferation.
Sullivan TB, Robert LC, Teebagy PA, Morgan SE, Beatty EW, Cicuto BJ, Nowd PK, Rieger-Christ KM, Bryan DJ., Neural Regen Res 13(7), 2018
PMID: 30028335
The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics.
Zaballa ME, van der Goot FG., Crit Rev Biochem Mol Biol 53(4), 2018
PMID: 29999430
MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology.
Muñoz-Llanos M, García-Pérez MA, Xu X, Tejos-Bravo M, Vidal EA, Moyano TC, Gutiérrez RA, Aguayo FI, Pacheco A, García-Rojo G, Aliaga E, Rojas PS, Cidlowski JA, Fiedler JL., Front Mol Neurosci 11(), 2018
PMID: 30127715
Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization.
Nakahata Y, Yasuda R., Front Synaptic Neurosci 10(), 2018
PMID: 30210329
Biological functions, regulatory mechanisms, and disease relevance of RNA localization pathways.
Bovaird S, Patel D, Padilla JA, Lécuyer E., FEBS Lett 592(17), 2018
PMID: 30132838
Epigenetic modulation during hippocampal development.
Fan SJ, Sun AB, Liu L., Biomed Rep 9(6), 2018
PMID: 30546873
Integrated Epigenetics, Transcriptomics, and Metabolomics to Analyze the Mechanisms of Benzo[a]pyrene Neurotoxicity in the Hippocampus.
Wang J, Li CL, Tu BJ, Yang K, Mo TT, Zhang RY, Cheng SQ, Chen CZ, Jiang XJ, Han TL, Peng B, Baker PN, Xia YY., Toxicol Sci 166(1), 2018
PMID: 30085273
Fear conditioning downregulates miR-138 expression in the hippocampus to facilitate the formation of fear memory.
Li DW, Liu JZ, Li SC, Yang JB, Sun HH, Wang AH., Neuroreport 29(16), 2018
PMID: 30199441
MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis.
Stappert L, Klaus F, Brüstle O., Front Neurosci 12(), 2018
PMID: 30455620
MicroRNA-Mediated Rescue of Fear Extinction Memory by miR-144-3p in Extinction-Impaired Mice.
Murphy CP, Li X, Maurer V, Oberhauser M, Gstir R, Wearick-Silva LE, Viola TW, Schafferer S, Grassi-Oliveira R, Whittle N, Hüttenhofer A, Bredy TW, Singewald N., Biol Psychiatry 81(12), 2017
PMID: 28104225
MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?
Nadim WD, Simion V, Benedetti H, Pichon C, Baril P, Morisset-Lopez S., Curr Neuropharmacol 15(2), 2017
PMID: 27396304
Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models.
Jhelum P, Karisetty BC, Kumar A, Chakravarty S., Curr Neuropharmacol 15(6), 2017
PMID: 27964703
Activity-dependent spatially localized miRNA maturation in neuronal dendrites.
Sambandan S, Akbalik G, Kochen L, Rinne J, Kahlstatt J, Glock C, Tushev G, Alvarez-Castelao B, Heckel A, Schuman EM., Science 355(6325), 2017
PMID: 28183980
miRNAs in synapse development and synaptic plasticity.
Hu Z, Li Z., Curr Opin Neurobiol 45(), 2017
PMID: 28334640
MicroRNA-182 Regulates Neurite Outgrowth Involving the PTEN/AKT Pathway.
Wang WM, Lu G, Su XW, Lyu H, Poon WS., Front Cell Neurosci 11(), 2017
PMID: 28442995
Proteomics insights into infantile neuronal ceroid lipofuscinosis (CLN1) point to the involvement of cilia pathology in the disease.
Segal-Salto M, Hansson K, Sapir T, Kaplan A, Levy T, Schweizer M, Frotscher M, James P, Reiner O., Hum Mol Genet 26(9), 2017
PMID: 28334871
Targeting the Ras palmitoylation/depalmitoylation cycle in cancer.
Lin DTS, Davis NG, Conibear E., Biochem Soc Trans 45(4), 2017
PMID: 28630138
MicroRNAs in neural development: from master regulators to fine-tuners.
Rajman M, Schratt G., Development 144(13), 2017
PMID: 28676566
Gene regulation in adult neural stem cells. Current challenges and possible applications.
Encinas JM, Fitzsimons CP., Adv Drug Deliv Rev 120(), 2017
PMID: 28751200
The malleable brain: plasticity of neural circuits and behavior - a review from students to students.
Schaefer N, Rotermund C, Blumrich EM, Lourenco MV, Joshi P, Hegemann RU, Jamwal S, Ali N, García Romero EM, Sharma S, Ghosh S, Sinha JK, Loke H, Jain V, Lepeta K, Salamian A, Sharma M, Golpich M, Nawrotek K, Paidi RK, Shahidzadeh SM, Piermartiri T, Amini E, Pastor V, Wilson Y, Adeniyi PA, Datusalia AK, Vafadari B, Saini V, Suárez-Pozos E, Kushwah N, Fontanet P, Turner AJ., J Neurochem 142(6), 2017
PMID: 28632905
Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.
Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P, Duan J., Cell Stem Cell 21(3), 2017
PMID: 28803920
Is Arc mRNA Unique: A Search for mRNAs That Localize to the Distal Dendrites of Dentate Gyrus Granule Cells Following Neural Activity.
de Solis CA, Morales AA, Hosek MP, Partin AC, Ploski JE., Front Mol Neurosci 10(), 2017
PMID: 29066948
miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy.
Bielefeld P, Mooney C, Henshall DC, Fitzsimons CP., Brain Plast 3(1), 2017
PMID: 29765859
Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes.
Wang DO, Ninomiya K, Mori C, Koyama A, Haan M, Kitabatake M, Hagiwara M, Chida K, Takahashi SI, Ohno M, Kataoka N., Front Mol Biosci 4(), 2017
PMID: 29312956
Blocking miRNA Biogenesis in Adult Forebrain Neurons Enhances Seizure Susceptibility, Fear Memory, and Food Intake by Increasing Neuronal Responsiveness.
Fiorenza A, Lopez-Atalaya JP, Rovira V, Scandaglia M, Geijo-Barrientos E, Barco A., Cereb Cortex 26(4), 2016
PMID: 25595182
Pathogenetic and therapeutic applications of microRNAs in major depressive disorder.
Dwivedi Y., Prog Neuropsychopharmacol Biol Psychiatry 64(), 2016
PMID: 25689819
Differential effects of social and physical environmental enrichment on brain plasticity, cognition, and ultrasonic communication in rats.
Brenes JC, Lackinger M, Höglinger GU, Schratt G, Schwarting RK, Wöhr M., J Comp Neurol 524(8), 2016
PMID: 26132842
MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints.
Wei J, Nduom EK, Kong LY, Hashimoto Y, Xu S, Gabrusiewicz K, Ling X, Huang N, Qiao W, Zhou S, Ivan C, Fuller GN, Gilbert MR, Overwijk W, Calin GA, Heimberger AB., Neuro Oncol 18(5), 2016
PMID: 26658052
KCC2 knockdown impairs glycinergic synapse maturation in cultured spinal cord neurons.
Schwale C, Schumacher S, Bruehl C, Titz S, Schlicksupp A, Kokocinska M, Kirsch J, Draguhn A, Kuhse J., Histochem Cell Biol 145(6), 2016
PMID: 26780567
A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation.
Viader A, Ogasawara D, Joslyn CM, Sanchez-Alavez M, Mori S, Nguyen W, Conti B, Cravatt BF., Elife 5(), 2016
PMID: 26779719
Role of MicroRNA in Governing Synaptic Plasticity.
Ye Y, Xu H, Su X, He X., Neural Plast 2016(), 2016
PMID: 27034846
MicroRNA-138 suppresses proliferation, invasion and glycolysis in malignant melanoma cells by targeting HIF-1α.
Chen Y, Cao KE, Wang S, Chen J, He B, He GU, Chen Y, Peng B, Zhou J., Exp Ther Med 11(6), 2016
PMID: 27284341
MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki).
Irie K, Tsujimura K, Nakashima H, Nakashima K., J Biol Chem 291(26), 2016
PMID: 27129236
miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a.
Xue Q, Yu C, Wang Y, Liu L, Zhang K, Fang C, Liu F, Bian G, Song B, Yang A, Ju G, Wang J., Sci Rep 6(), 2016
PMID: 27221778
Axonal localization and mitochondrial association of precursor microRNA 338.
Vargas JN, Kar AN, Kowalak JA, Gale JR, Aschrafi A, Chen CY, Gioio AE, Kaplan BB., Cell Mol Life Sci 73(22), 2016
PMID: 27229124
All Roads Lead to the miRNome: miRNAs Have a Central Role in the Molecular Pathophysiology of Psychiatric Disorders.
O'Connor RM, Gururajan A, Dinan TG, Kenny PJ, Cryan JF., Trends Pharmacol Sci 37(12), 2016
PMID: 27832923
mRNA changes in nucleus accumbens related to methamphetamine addiction in mice.
Zhu L, Li J, Dong N, Guan F, Liu Y, Ma D, Goh EL, Chen T., Sci Rep 6(), 2016
PMID: 27869204
Vimentin regulates neuroplasticity in transected spinal cord rats associated with micRNA138.
Qian BJ, You L, Shang FF, Liu J, Dai P, Lin N, He M, Liu R, Zhang Y, Xu Y, Zhang YH, Wang TH., Mol Neurobiol 51(2), 2015
PMID: 24874717
Heterogeneity and individuality: microRNAs in mental disorders.
Hommers LG, Domschke K, Deckert J., J Neural Transm (Vienna) 122(1), 2015
PMID: 25395183
Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy.
Miller-Delaney SF, Bryan K, Das S, McKiernan RC, Bray IM, Reynolds JP, Gwinn R, Stallings RL, Henshall DC., Brain 138(pt 3), 2015
PMID: 25552301
Neuroepigenetic Regulation of Pathogenic Memories.
Sillivan SE, Vaissière T, Miller CA., Neuroepigenetics 1(), 2015
PMID: 25642412
miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.
Berg V, Rusch M, Vartak N, Jüngst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP., Blood 125(19), 2015
PMID: 25670628
MicroRNA-138 promotes tau phosphorylation by targeting retinoic acid receptor alpha.
Wang X, Tan L, Lu Y, Peng J, Zhu Y, Zhang Y, Sun Z., FEBS Lett 589(6), 2015
PMID: 25680531
Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease.
Garza-Manero S, Arias C, Bermúdez-Rattoni F, Vaca L, Zepeda A., Front Cell Neurosci 9(), 2015
PMID: 25745387
The physiology of protein S-acylation.
Chamberlain LH, Shipston MJ., Physiol Rev 95(2), 2015
PMID: 25834228
A coding-independent function of an alternative Ube3a transcript during neuronal development.
Valluy J, Bicker S, Aksoy-Aksel A, Lackinger M, Sumer S, Fiore R, Wüst T, Seffer D, Metge F, Dieterich C, Wöhr M, Schwarting R, Schratt G., Nat Neurosci 18(5), 2015
PMID: 25867122
Identification of novel post-transcriptional features in olfactory receptor family mRNAs.
Shum EY, Espinoza JL, Ramaiah M, Wilkinson MF., Nucleic Acids Res 43(19), 2015
PMID: 25908788
Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons.
Gao Y, Su J, Guo W, Polich ED, Magyar DP, Xing Y, Li H, Smrt RD, Chang Q, Zhao X., Stem Cells 33(5), 2015
PMID: 25639236
Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model.
Marjonen H, Sierra A, Nyman A, Rogojin V, Gröhn O, Linden AM, Hautaniemi S, Kaminen-Ahola N., PLoS One 10(5), 2015
PMID: 25970770
Identification of precursor microRNAs within distal axons of sensory neuron.
Kim HH, Kim P, Phay M, Yoo S., J Neurochem 134(2), 2015
PMID: 25919946
Association of N-cadherin levels and downstream effectors of Rho GTPases with dendritic spine loss induced by chronic stress in rat hippocampal neurons.
Castañeda P, Muñoz M, García-Rojo G, Ulloa JL, Bravo JA, Márquez R, García-Pérez MA, Arancibia D, Araneda K, Rojas PS, Mondaca-Ruff D, Díaz-Véliz G, Mora S, Aliaga E, Fiedler JL., J Neurosci Res 93(10), 2015
PMID: 26010004
Chronic methamphetamine regulates the expression of MicroRNAs and putative target genes in the nucleus accumbens of mice.
Zhu L, Zhu J, Liu Y, Chen Y, Li Y, Chen S, Li T, Dang Y, Chen T., J Neurosci Res 93(10), 2015
PMID: 26031216
Non-coding mechanisms of local mRNA translation in neuronal dendrites.
Weiss K, Antoniou A, Schratt G., Eur J Cell Biol 94(7-9), 2015
PMID: 26071834
A large-scale functional screen identifies Nova1 and Ncoa3 as regulators of neuronal miRNA function.
Störchel PH, Thümmler J, Siegel G, Aksoy-Aksel A, Zampa F, Sumer S, Schratt G., EMBO J 34(17), 2015
PMID: 26105073
The miR-199-dynamin regulatory axis controls receptor-mediated endocytosis.
Aranda JF, Canfrán-Duque A, Goedeke L, Suárez Y, Fernández-Hernando C., J Cell Sci 128(17), 2015
PMID: 26163491
Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder.
Forstner AJ, Hofmann A, Maaser A, Sumer S, Khudayberdiev S, Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Schumacher J, Breuer R, Meier S, Herms S, Hoffmann P, Lacour A, Witt SH, Reif A, Müller-Myhsok B, Lucae S, Maier W, Schwarz M, Vedder H, Kammerer-Ciernioch J, Pfennig A, Bauer M, Hautzinger M, Moebus S, Priebe L, Sivalingam S, Verhaert A, Schulz H, Czerski PM, Hauser J, Lissowska J, Szeszenia-Dabrowska N, Brennan P, McKay JD, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Krasnov V, Chuchalin A, Babadjanova G, Pantelejeva G, Abramova LI, Tiganov AS, Polonikov A, Khusnutdinova E, Alda M, Cruceanu C, Rouleau GA, Turecki G, Laprise C, Rivas F, Mayoral F, Kogevinas M, Grigoroiu-Serbanescu M, Propping P, Becker T, Rietschel M, Cichon S, Schratt G, Nöthen MM., Transl Psychiatry 5(), 2015
PMID: 26556287
MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability.
Li J, Chen Y, Qin X, Wen J, Ding H, Xia W, Li S, Su X, Wang W, Li H, Zhao Q, Fang T, Qu L, Shao N., Nucleic Acids Res 42(1), 2014
PMID: 24057215
Selective distribution and dynamic modulation of miRNAs in the synapse and its possible role in Alzheimer's Disease.
Garza-Manero S, Pichardo-Casas I, Arias C, Vaca L, Zepeda A., Brain Res 1584(), 2014
PMID: 24355599
Role of miRNAs and epigenetics in neural stem cell fate determination.
Lopez-Ramirez MA, Nicoli S., Epigenetics 9(1), 2014
PMID: 24342893
Dendritic spines: the locus of structural and functional plasticity.
Sala C, Segal M., Physiol Rev 94(1), 2014
PMID: 24382885
The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins.
Vartak N, Papke B, Grecco HE, Rossmannek L, Waldmann H, Hedberg C, Bastiaens PI., Biophys J 106(1), 2014
PMID: 24411241
Transcriptome-wide discovery of microRNA binding sites in human brain.
Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL., Neuron 81(2), 2014
PMID: 24389009
NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo.
Pai B, Siripornmongcolchai T, Berentsen B, Pakzad A, Vieuille C, Pallesen S, Pajak M, Simpson TI, Armstrong JD, Wibrand K, Bramham CR., Front Cell Neurosci 7(), 2014
PMID: 24454279
MicroRNAs in brain development and function: a matter of flexibility and stability.
Follert P, Cremer H, Béclin C., Front Mol Neurosci 7(), 2014
PMID: 24570654
Mechanistic effects of protein palmitoylation and the cellular consequences thereof.
Blaskovic S, Adibekian A, Blanc M, van der Goot GF., Chem Phys Lipids 180(), 2014
PMID: 24534427
Gephyrin: a master regulator of neuronal function?
Tyagarajan SK, Fritschy JM., Nat Rev Neurosci 15(3), 2014
PMID: 24552784
Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7.
Heinonen AM, Rahman M, Dogbevia G, Jakobi H, Wölfl S, Sprengel R, Schwaninger M., BMC Neurosci 15(), 2014
PMID: 24618040
The impact of MIR137 on dorsolateral prefrontal-hippocampal functional connectivity in healthy subjects.
Liu B, Zhang X, Hou B, Li J, Qiu C, Qin W, Yu C, Jiang T., Neuropsychopharmacology 39(9), 2014
PMID: 24625753
microRNAs in axon guidance.
Iyer AN, Bellon A, Baudet ML., Front Cell Neurosci 8(), 2014
PMID: 24672429
Non-coding RNA regulation of synaptic plasticity and memory: implications for aging.
Earls LR, Westmoreland JJ, Zakharenko SS., Ageing Res Rev 17(), 2014
PMID: 24681292
A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency.
Pan D, Flores O, Umbach JL, Pesola JM, Bentley P, Rosato PC, Leib DA, Cullen BR, Coen DM., Cell Host Microbe 15(4), 2014
PMID: 24721573
Epigenetic memory: the Lamarckian brain.
Fischer A., EMBO J 33(9), 2014
PMID: 24719207
Neuronal activity-dependent regulation of MicroRNAs.
Sim SE, Bakes J, Kaang BK., Mol Cells 37(7), 2014
PMID: 24957213
MicroRNA 340 is involved in UVB-induced dendrite formation through the regulation of RhoA expression in melanocytes.
Jian Q, An Q, Zhu D, Hui K, Liu Y, Chi S, Li C., Mol Cell Biol 34(18), 2014
PMID: 24980435
MicroRNA-132, -134, and -138: a microRNA troika rules in neuronal dendrites.
Bicker S, Lackinger M, Weiß K, Schratt G., Cell Mol Life Sci 71(20), 2014
PMID: 25008044
MicroRNA-138 is a potential regulator of memory performance in humans.
Schröder J, Ansaloni S, Schilling M, Liu T, Radke J, Jaedicke M, Schjeide BM, Mashychev A, Tegeler C, Radbruch H, Papenberg G, Düzel S, Demuth I, Bucholtz N, Lindenberger U, Li SC, Steinhagen-Thiessen E, Lill CM, Bertram L., Front Hum Neurosci 8(), 2014
PMID: 25071529
Virus meets host microRNA: the destroyer, the booster, the hijacker.
Guo YE, Steitz JA., Mol Cell Biol 34(20), 2014
PMID: 25047834
MiR-134-dependent regulation of Pumilio-2 is necessary for homeostatic synaptic depression.
Fiore R, Rajman M, Schwale C, Bicker S, Antoniou A, Bruehl C, Draguhn A, Schratt G., EMBO J 33(19), 2014
PMID: 25097251
MicroRNA-137 regulates a glucocorticoid receptor-dependent signalling network: implications for the etiology of schizophrenia.
Vallès A, Martens GJ, De Weerd P, Poelmans G, Aschrafi A., J Psychiatry Neurosci 39(5), 2014
PMID: 24866554
MicroRNAs and synaptic plasticity--a mutual relationship.
Aksoy-Aksel A, Zampa F, Schratt G., Philos Trans R Soc Lond B Biol Sci 369(1652), 2014
PMID: 25135976
miR-143 regulates hexokinase 2 expression in cancer cells.
Peschiaroli A, Giacobbe A, Formosa A, Markert EK, Bongiorno-Borbone L, Levine AJ, Candi E, D'Alessandro A, Zolla L, Finazzi Agrò A, Melino G., Oncogene 32(6), 2013
PMID: 22469988
General principals of miRNA biogenesis and regulation in the brain.
O'Carroll D, Schaefer A., Neuropsychopharmacology 38(1), 2013
PMID: 22669168
Non-coding RNAs in Alzheimer's disease.
Tan L, Yu JT, Hu N, Tan L., Mol Neurobiol 47(1), 2013
PMID: 23054683
Role of microRNAs in Semaphorin function and neural circuit formation.
Baudet ML, Bellon A, Holt CE., Semin Cell Dev Biol 24(3), 2013
PMID: 23219835
Fat chance! Getting a grip on a slippery modification.
Tom CT, Martin BR., ACS Chem Biol 8(1), 2013
PMID: 23215442
Dendritic protein synthesis in the normal and diseased brain.
Swanger SA, Bassell GJ., Neuroscience 232(), 2013
PMID: 23262237
Evaluating the microRNA targeting sites by luciferase reporter gene assay.
Jin Y, Chen Z, Liu X, Zhou X., Methods Mol Biol 936(), 2013
PMID: 23007504
microRNAs: innovative targets for cerebral ischemia and stroke.
Ouyang YB, Stary CM, Yang GY, Giffard R., Curr Drug Targets 14(1), 2013
PMID: 23170800
Profiling and inhibiting reversible palmitoylation.
Hernandez JL, Majmudar JD, Martin BR., Curr Opin Chem Biol 17(1), 2013
PMID: 23287289
miR-124-regulated RhoG: A conductor of neuronal process complexity.
Schumacher S, Franke K., Small GTPases 4(1), 2013
PMID: 23303397
MicroRNA-182 regulates amygdala-dependent memory formation.
Griggs EM, Young EJ, Rumbaugh G, Miller CA., J Neurosci 33(4), 2013
PMID: 23345246
Role of microRNA-138 as a potential tumor suppressor in head and neck squamous cell carcinoma.
Jin Y, Chen D, Cabay RJ, Wang A, Crowe DL, Zhou X., Int Rev Cell Mol Biol 303(), 2013
PMID: 23445815
Regulation of microRNA biogenesis and turnover by animals and their viruses.
Libri V, Miesen P, van Rij RP, Buck AH., Cell Mol Life Sci 70(19), 2013
PMID: 23354060
Context-specific microRNA function in developmental complexity.
Carroll AP, Tooney PA, Cairns MJ., J Mol Cell Biol 5(2), 2013
PMID: 23362311
Exosomes as a novel way of interneuronal communication.
Chivet M, Javalet C, Hemming F, Pernet-Gallay K, Laulagnier K, Fraboulet S, Sadoul R., Biochem Soc Trans 41(1), 2013
PMID: 23356290
Large scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysis.
Filippova EV, Weston LA, Kuhn ML, Geissler B, Gehring AM, Armoush N, Adkins CT, Minasov G, Dubrovska I, Shuvalova L, Winsor JR, Lavis LD, Satchell KJ, Becker DP, Anderson WF, Johnson RJ., J Biol Chem 288(15), 2013
PMID: 23430251
Comparison of microRNA expression in hippocampus and the marginal division (MrD) of the neostriatum in rats.
Shu SY, Qing D, Wang B, Zeng QY, Chen YC, Jin Y, Zeng CC, Bao R., J Biomed Sci 20(), 2013
PMID: 23425148
microRNAs and the regulation of neuronal plasticity under stress conditions.
Schouten M, Aschrafi A, Bielefeld P, Doxakis E, Fitzsimons CP., Neuroscience 241(), 2013
PMID: 23500144
Short-term recognition memory correlates with regional CNS expression of microRNA-138 in mice.
Tatro ET, Risbrough V, Soontornniyomkij B, Young J, Shumaker-Armstrong S, Jeste DV, Achim CL., Am J Geriatr Psychiatry 21(5), 2013
PMID: 23570889
Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury.
Kaur P, Liu F, Tan JR, Lim KY, Sepramaniam S, Karolina DS, Armugam A, Jeyaseelan K., Brain Sci 3(1), 2013
PMID: 24961318
Integrative omics analysis reveals the importance and scope of translational repression in microRNA-mediated regulation.
Liu Q, Halvey PJ, Shyr Y, Slebos RJ, Liebler DC, Zhang B., Mol Cell Proteomics 12(7), 2013
PMID: 23550052
What does S-palmitoylation do to membrane proteins?
Blaskovic S, Blanc M, van der Goot FG., FEBS J 280(12), 2013
PMID: 23551889
Potential Impact of miR-137 and Its Targets in Schizophrenia.
Wright C, Turner JA, Calhoun VD, Perrone-Bizzozero N., Front Genet 4(), 2013
PMID: 23637704
The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134.
Bicker S, Khudayberdiev S, Weiß K, Zocher K, Baumeister S, Schratt G., Genes Dev 27(9), 2013
PMID: 23651854
Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression.
Gallego X, Cox RJ, Laughlin JR, Stitzel JA, Ehringer MA., PLoS One 8(5), 2013
PMID: 23691088
Suppression of tumorigenicity by microRNA-138 through inhibition of EZH2-CDK4/6-pRb-E2F1 signal loop in glioblastoma multiforme.
Qiu S, Huang D, Yin D, Li F, Li X, Kung HF, Peng Y., Biochim Biophys Acta 1832(10), 2013
PMID: 23707559
Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors.
Niphakis MJ, Cognetta AB, Chang JW, Buczynski MW, Parsons LH, Byrne F, Burston JJ, Chapman V, Cravatt BF., ACS Chem Neurosci 4(9), 2013
PMID: 23731016
Copper-induced deregulation of microRNA expression in the zebrafish olfactory system.
Wang L, Bammler TK, Beyer RP, Gallagher EP., Environ Sci Technol 47(13), 2013
PMID: 23745839
MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration.
Liu CM, Wang RY, Saijilafu, Jiao ZX, Zhang BY, Zhou FQ., Genes Dev 27(13), 2013
PMID: 23796896
Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.
Zhang MM, Zhang MM, Wu PY, Kelly FD, Nurse P, Hang HC., PLoS Biol 11(7), 2013
PMID: 23843742
MicroRNA in Alzheimer's disease: an exploratory study in brain, cerebrospinal fluid and plasma.
Bekris LM, Lutz F, Montine TJ, Yu CE, Tsuang D, Peskind ER, Leverenz JB., Biomarkers 18(5), 2013
PMID: 23822153
miRNAs in development and pathogenesis of the nervous system.
Nowak JS, Michlewski G., Biochem Soc Trans 41(4), 2013
PMID: 23863137
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii.
Kemp LE, Rusch M, Adibekian A, Bullen HE, Graindorge A, Freymond C, Rottmann M, Braun-Breton C, Baumeister S, Porfetye AT, Vetter IR, Hedberg C, Soldati-Favre D., J Biol Chem 288(38), 2013
PMID: 23913689
The interplay of microRNA and neuronal activity in health and disease.
Eacker SM, Dawson TM, Dawson VL., Front Cell Neurosci 7(), 2013
PMID: 23986658
Cardiotoxicity of mycotoxin citrinin and involvement of microRNA-138 in zebrafish embryos.
Wu TS, Yang JJ, Yu FY, Liu BH., Toxicol Sci 136(2), 2013
PMID: 24052562
Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures.
van Spronsen M, van Battum EY, Kuijpers M, Vangoor VR, Rietman ML, Pothof J, Gumy LF, van Ijcken WF, Akhmanova A, Pasterkamp RJ, Hoogenraad CC., PLoS One 8(10), 2013
PMID: 24098357
Chronic academic stress increases a group of microRNAs in peripheral blood.
Honda M, Kuwano Y, Katsuura-Kamano S, Kamezaki Y, Fujita K, Akaike Y, Kano S, Nishida K, Masuda K, Rokutan K., PLoS One 8(10), 2013
PMID: 24130753
MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9.
Chai S, Cambronne XA, Eichhorn SW, Goodman RH., Proc Natl Acad Sci U S A 110(44), 2013
PMID: 24127608
MicroRNAs in the pathophysiology and treatment of status epilepticus.
Henshall DC., Front Mol Neurosci 6(), 2013
PMID: 24282394
A comprehensive characterization of the nuclear microRNA repertoire of post-mitotic neurons.
Khudayberdiev SA, Zampa F, Rajman M, Schratt G., Front Mol Neurosci 6(), 2013
PMID: 24324399
Structural modulation of dendritic spines during synaptic plasticity.
Fortin DA, Srivastava T, Soderling TR., Neuroscientist 18(4), 2012
PMID: 21670426
Differentiation of single cell derived human mesenchymal stem cells into cells with a neuronal phenotype: RNA and microRNA expression profile.
Crobu F, Latini V, Marongiu MF, Sogos V, Scintu F, Porcu S, Casu C, Badiali M, Sanna A, Manchinu MF, Ristaldi MS., Mol Biol Rep 39(4), 2012
PMID: 21773948
MicroRNA networks direct neuronal development and plasticity.
Olde Loohuis NF, Kos A, Martens GJ, Van Bokhoven H, Nadif Kasri N, Aschrafi A., Cell Mol Life Sci 69(1), 2012
PMID: 21833581
Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology.
Berkel S, Tang W, Treviño M, Vogt M, Obenhaus HA, Gass P, Scherer SW, Sprengel R, Schratt G, Rappold GA., Hum Mol Genet 21(2), 2012
PMID: 21994763
Targeting microRNAs in neurons: tools and perspectives.
Ruberti F, Barbato C, Cogoni C., Exp Neurol 235(2), 2012
PMID: 22085592
miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis.
Rebustini IT, Hayashi T, Reynolds AD, Dillard ML, Carpenter EM, Hoffman MP., Development 139(1), 2012
PMID: 22115756
Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons.
Saba R, Störchel PH, Aksoy-Aksel A, Kepura F, Lippi G, Plant TD, Schratt GM., Mol Cell Biol 32(3), 2012
PMID: 22144581
Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases.
Young FB, Butland SL, Sanders SS, Sutton LM, Hayden MR., Prog Neurobiol 97(2), 2012
PMID: 22155432
Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation.
Pichardo-Casas I, Goff LA, Swerdel MR, Athie A, Davila J, Ramos-Brossier M, Lapid-Volosin M, Friedman WJ, Hart RP, Vaca L., Brain Res 1436(), 2012
PMID: 22197703
Post-transcriptional trafficking and regulation of neuronal gene expression.
Goldie BJ, Cairns MJ., Mol Neurobiol 45(1), 2012
PMID: 22167484
Regulation of the actin cytoskeleton in dendritic spines.
Penzes P, Rafalovich I., Adv Exp Med Biol 970(), 2012
PMID: 22351052
G protein trafficking.
Wedegaertner PB., Subcell Biochem 63(), 2012
PMID: 23161140
Targeting protein lipidation in disease.
Resh MD., Trends Mol Med 18(4), 2012
PMID: 22342806
HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.
Kundu P, Fabian MR, Sonenberg N, Bhattacharyya SN, Filipowicz W., Nucleic Acids Res 40(11), 2012
PMID: 22362743
Non-coding RNAs--novel targets in neurotoxicity.
Tal TL, Tanguay RL., Neurotoxicology 33(3), 2012
PMID: 22394481
MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction.
Xu B, Hsu PK, Karayiorgou M, Gogos JA., Neurobiol Dis 46(2), 2012
PMID: 22406400
MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating.
Scott H, Howarth J, Lee YB, Wong LF, Bantounas I, Phylactou L, Verkade P, Uney JB., J Biol Chem 287(18), 2012
PMID: 22393045
Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels.
Tian L, McClafferty H, Knaus HG, Ruth P, Shipston MJ., J Biol Chem 287(18), 2012
PMID: 22399288
MicroRNAs in neuronal function and dysfunction.
Im HI, Kenny PJ., Trends Neurosci 35(5), 2012
PMID: 22436491
Dynamic Roles of microRNAs in Neurogenesis.
Lang MF, Shi Y., Front Neurosci 6(), 2012
PMID: 22661924
Emerging role of neuronal exosomes in the central nervous system.
Chivet M, Hemming F, Pernet-Gallay K, Fraboulet S, Sadoul R., Front Physiol 3(), 2012
PMID: 22654762
Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression.
Eipper-Mains JE, Eipper BA, Mains RE., Front Genet 3(), 2012
PMID: 22707957
The Emerging Role of Non-Coding RNAs in Drug Addiction.
Sartor GC, St Laurent G, Wahlestedt C., Front Genet 3(), 2012
PMID: 22737160
MicroRNA regulation of the synaptic plasticity-related gene Arc.
Wibrand K, Pai B, Siripornmongcolchai T, Bittins M, Berentsen B, Ofte ML, Weigel A, Skaftnesmo KO, Bramham CR., PLoS One 7(7), 2012
PMID: 22844515
MicroRNAs shape the neuronal landscape.
McNeill E, Van Vactor D., Neuron 75(3), 2012
PMID: 22884321
Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia.
Earls LR, Fricke RG, Yu J, Berry RB, Baldwin LT, Zakharenko SS., J Neurosci 32(41), 2012
PMID: 23055483
Neurofibromin 1 is a miRNA target in neurons.
Paschou M, Doxakis E., PLoS One 7(10), 2012
PMID: 23056445
Protein palmitoylation and pathogenesis in apicomplexan parasites.
Corvi MM, Alonso AM, Caballero MC., J Biomed Biotechnol 2012(), 2012
PMID: 23093847
miRNA regulons associated with synaptic function.
Paschou M, Paraskevopoulou MD, Vlachos IS, Koukouraki P, Hatzigeorgiou AG, Doxakis E., PLoS One 7(10), 2012
PMID: 23071543
Neurodegeneration as an RNA disorder.
Johnson R, Noble W, Tartaglia GG, Buckley NJ., Prog Neurobiol 99(3), 2012
PMID: 23063563
Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice.
Majer A, Medina SJ, Niu Y, Abrenica B, Manguiat KJ, Frost KL, Philipson CS, Sorensen DL, Booth SA., PLoS Pathog 8(11), 2012
PMID: 23144617
Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy.
Corti S, Nizzardo M, Simone C, Falcone M, Nardini M, Ronchi D, Donadoni C, Salani S, Riboldi G, Magri F, Menozzi G, Bonaglia C, Rizzo F, Bresolin N, Comi GP., Sci Transl Med 4(165), 2012
PMID: 23253609
MicroRNA expression changes during zebrafish development induced by perfluorooctane sulfonate.
Zhang L, Li YY, Zeng HC, Wei J, Wan YJ, Chen J, Xu SQ., J Appl Toxicol 31(3), 2011
PMID: 20878907
Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma.
Jiang L, Dai Y, Liu X, Wang C, Wang A, Chen Z, Heidbreder CE, Kolokythas A, Zhou X., Hum Genet 129(2), 2011
PMID: 21079996
Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways.
Muiños-Gimeno M, Espinosa-Parrilla Y, Guidi M, Kagerbauer B, Sipilä T, Maron E, Pettai K, Kananen L, Navinés R, Martín-Santos R, Gratacòs M, Metspalu A, Hovatta I, Estivill X., Biol Psychiatry 69(6), 2011
PMID: 21168126
Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy.
Ladygina N, Martin BR, Altman A., Adv Immunol 109(), 2011
PMID: 21569911
Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect.
Bano D, Agostini M, Melino G, Nicotera P., Mol Neurobiol 43(2), 2011
PMID: 21234815
MicroRNA in central nervous system trauma and degenerative disorders.
Liu NK, Xu XM., Physiol Genomics 43(10), 2011
PMID: 21385946
MicroRNAs in addiction: adaptation's middlemen?
Li MD, van der Vaart AD., Mol Psychiatry 16(12), 2011
PMID: 21606928
Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling.
Muddashetty RS, Nalavadi VC, Gross C, Yao X, Xing L, Laur O, Warren ST, Bassell GJ., Mol Cell 42(5), 2011
PMID: 21658607
Up-regulation of microRNAs in brain of human alcoholics.
Lewohl JM, Nunez YO, Dodd PR, Tiwari GR, Harris RA, Mayfield RD., Alcohol Clin Exp Res 35(11), 2011
PMID: 21651580
MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression.
Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T., Mol Cancer Res 9(8), 2011
PMID: 21693595
MicroRNA regulation of homeostatic synaptic plasticity.
Cohen JE, Lee PR, Chen S, Li W, Fields RD., Proc Natl Acad Sci U S A 108(28), 2011
PMID: 21697510
microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs.
Eipper-Mains JE, Kiraly DD, Palakodeti D, Mains RE, Eipper BA, Graveley BR., RNA 17(8), 2011
PMID: 21708909
A study of neural-related microRNAs in the developing amphioxus.
Candiani S, Moronti L, De Pietri Tonelli D, Garbarino G, Pestarino M., Evodevo 2(), 2011
PMID: 21722366
MicroRNAs in development and disease.
Sayed D, Abdellatif M., Physiol Rev 91(3), 2011
PMID: 21742789
Review of MicroRNA Deregulation in Oral Cancer. Part I.
Kolokythas A, Miloro M, Zhou X., J Oral Maxillofac Res 2(2), 2011
PMID: 24421988
The microRNA contribution to learning and memory.
Konopka W, Schütz G, Kaczmarek L., Neuroscientist 17(5), 2011
PMID: 21734154
Understanding the functional significance of ghrelin processing and degradation.
Satou M, Nakamura Y, Ando H, Sugimoto H., Peptides 32(11), 2011
PMID: 21763742
Axotomy-induced miR-21 promotes axon growth in adult dorsal root ganglion neurons.
Strickland IT, Richards L, Holmes FE, Wynick D, Uney JB, Wong LF., PLoS One 6(8), 2011
PMID: 21853131
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression.
Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Uneo S, Koyasu T, Matsui R, Chérasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T., Nat Neurosci 14(9), 2011
PMID: 21857657
Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.
Lippi G, Steinert JR, Marczylo EL, D'Oro S, Fiore R, Forsythe ID, Schratt G, Zoli M, Nicotera P, Young KW., J Cell Biol 194(6), 2011
PMID: 21930776
Mnemonic microRNAs help make memories.
Leslie M., J Cell Biol 194(6), 2011
PMID: PMC3207282
Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design.
Hedberg C, Dekker FJ, Rusch M, Renner S, Wetzel S, Vartak N, Gerding-Reimers C, Bon RS, Bastiaens PI, Waldmann H., Angew Chem Int Ed Engl 50(42), 2011
PMID: 21905185
NMDA mediated contextual conditioning changes miRNA expression.
Kye MJ, Neveu P, Lee YS, Zhou M, Steen JA, Sahin M, Kosik KS, Silva AJ., PLoS One 6(9), 2011
PMID: 21931811
microRNA-34c is a novel target to treat dementias.
Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Edbauer D, Rao P, Farinelli L, Delalle I, Schmitt A, Falkai P, Bahari-Javan S, Burkhardt S, Sananbenesi F, Fischer A., EMBO J 30(20), 2011
PMID: 21946562
miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132.
Jimenez-Mateos EM, Bray I, Sanz-Rodriguez A, Engel T, McKiernan RC, Mouri G, Tanaka K, Sano T, Saugstad JA, Simon RP, Stallings RL, Henshall DC., Am J Pathol 179(5), 2011
PMID: 21945804
Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes.
Keck-Wherley J, Grover D, Bhattacharyya S, Xu X, Holman D, Lombardini ED, Verma R, Biswas R, Galdzicki Z., Dev Neurosci 33(5), 2011
PMID: 22042248
MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines.
Liu X, Wang C, Chen Z, Jin Y, Wang Y, Kolokythas A, Dai Y, Zhou X., Biochem J 440(1), 2011
PMID: 21770894
MicroRNAs in neural cell development and brain diseases.
Feng W, Feng Y., Sci China Life Sci 54(12), 2011
PMID: 22227902
Inference of gene regulation via miRNAs during ES cell differentiation using MiRaGE method.
Yoshizawa M, Taguchi YH, Yasuda J., Int J Mol Sci 12(12), 2011
PMID: 22272132
Defining larger roles for "tiny" RNA molecules: role of miRNAs in neurodegeneration research.
Yelamanchili SV, Fox HS., J Neuroimmune Pharmacol 5(1), 2010
PMID: 19757077
Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways.
Saneyoshi T, Fortin DA, Soderling TR., Curr Opin Neurobiol 20(1), 2010
PMID: 19896363
miR-138 might reverse multidrug resistance of leukemia cells.
Zhao X, Yang L, Hu J, Ruan J., Leuk Res 34(8), 2010
PMID: 19896708
Subcellular targeting strategies for drug design and delivery.
Rajendran L, Knölker HJ, Simons K., Nat Rev Drug Discov 9(1), 2010
PMID: 20043027
Dysregulated microRNAs in neurodegenerative disorders.
Lau P, de Strooper B., Semin Cell Dev Biol 21(7), 2010
PMID: 20080199
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132.
Edbauer D, Neilson JR, Foster KA, Wang CF, Seeburg DP, Batterton MN, Tada T, Dolan BM, Sharp PA, Sheng M., Neuron 65(3), 2010
PMID: 20159450
Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
Wibrand K, Panja D, Tiron A, Ofte ML, Skaftnesmo KO, Lee CS, Pena JT, Tuschl T, Bramham CR., Eur J Neurosci 31(4), 2010
PMID: 20384810
Protein palmitoylation in neuronal development and synaptic plasticity.
Fukata Y, Fukata M., Nat Rev Neurosci 11(3), 2010
PMID: 20168314
RNA localization in neurite morphogenesis and synaptic regulation: current evidence and novel approaches.
Mikl M, Vendra G, Doyle M, Kiebler MA., J Comp Physiol A Neuroethol Sens Neural Behav Physiol 196(5), 2010
PMID: 20237785
Spatially restricting gene expression by local translation at synapses.
Wang DO, Martin KC, Zukin RS., Trends Neurosci 33(4), 2010
PMID: 20303187
Understanding neuronal connectivity through the post-transcriptional toolkit.
Loya CM, Van Vactor D, Fulga TA., Genes Dev 24(7), 2010
PMID: 20360381
Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures.
Tsang JS, Ebert MS, van Oudenaarden A., Mol Cell 38(1), 2010
PMID: 20385095
MicroRNAs in neuronal development, function and dysfunction.
Saba R, Schratt GM., Brain Res 1338(), 2010
PMID: 20380818
Mechanisms of translational regulation in synaptic plasticity.
Sossin WS, Lacaille JC., Curr Opin Neurobiol 20(4), 2010
PMID: 20430610
MicroRNA pathways in neural development and plasticity.
Vo NK, Cambronne XA, Goodman RH., Curr Opin Neurobiol 20(4), 2010
PMID: 20447821
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.
Smrt RD, Szulwach KE, Pfeiffer RL, Li X, Guo W, Pathania M, Teng ZQ, Luo Y, Peng J, Bordey A, Jin P, Zhao X., Stem Cells 28(6), 2010
PMID: 20506192
Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons.
Natera-Naranjo O, Aschrafi A, Gioio AE, Kaplan BB., RNA 16(8), 2010
PMID: 20584895
miRNA malfunction causes spinal motor neuron disease.
Haramati S, Chapnik E, Sztainberg Y, Eilam R, Zwang R, Gershoni N, McGlinn E, Heiser PW, Wills AM, Wirguin I, Rubin LL, Misawa H, Tabin CJ, Brown R, Chen A, Hornstein E., Proc Natl Acad Sci U S A 107(29), 2010
PMID: 20616011
The widespread regulation of microRNA biogenesis, function and decay.
Krol J, Loedige I, Filipowicz W., Nat Rev Genet 11(9), 2010
PMID: 20661255
Epigenetic regulation of neuronal dendrite and dendritic spine development.
Smrt RD, Zhao X., Front Biol (Beijing) 5(4), 2010
PMID: 25635180
Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome.
Wu H, Tao J, Chen PJ, Shahab A, Ge W, Hart RP, Ruan X, Ruan Y, Sun YE., Proc Natl Acad Sci U S A 107(42), 2010
PMID: 20921386
MicroRNA loss enhances learning and memory in mice.
Konopka W, Kiryk A, Novak M, Herwerth M, Parkitna JR, Wawrzyniak M, Kowarsch A, Michaluk P, Dzwonek J, Arnsperger T, Wilczynski G, Merkenschlager M, Theis FJ, Köhr G, Kaczmarek L, Schütz G., J Neurosci 30(44), 2010
PMID: 21048142
MicroRNA regulation of neural stem cells and neurogenesis.
Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S, Neveu P, Kosik KS., J Neurosci 30(45), 2010
PMID: 21068294
microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus.
Magill ST, Cambronne XA, Luikart BW, Lioy DT, Leighton BH, Westbrook GL, Mandel G, Goodman RH., Proc Natl Acad Sci U S A 107(47), 2010
PMID: 21059906
Palmitoylation and depalmitoylation dynamics at a glance.
Conibear E, Davis NG., J Cell Sci 123(pt 23), 2010
PMID: 21084560
The intracellular dynamic of protein palmitoylation.
Salaun C, Greaves J, Chamberlain LH., J Cell Biol 191(7), 2010
PMID: 21187327
Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels.
Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW, Kim TK, Greenberg ME, Schratt G., EMBO J 28(6), 2009
PMID: 19197241
Fine-tuning neural gene expression with microRNAs.
Schratt G., Curr Opin Neurobiol 19(2), 2009
PMID: 19539460
MicroRNA-mediated regulation of synaptic palmitoylation: shrinking fat spines.
Carrel D, Firestein BL., Nat Cell Biol 11(6), 2009
PMID: 19488059
What are the roles of microRNAs at the mammalian synapse?
Konecna A, Heraud JE, Schoderboeck L, Raposo AA, Kiebler MA., Neurosci Lett 466(2), 2009
PMID: 19545603
Macro role(s) of microRNAs in fragile X syndrome?
Li X, Jin P., Neuromolecular Med 11(3), 2009
PMID: 19669947
MicroRNAs tell an evo-devo story.
Kosik KS., Nat Rev Neurosci 10(10), 2009
PMID: 19738624
Environmental regulation of the neural epigenome.
Sng J, Meaney MJ., Epigenomics 1(1), 2009
PMID: 22122640
microRNAs at the synapse.
Schratt G., Nat Rev Neurosci 10(12), 2009
PMID: 19888283
Understanding microRNAs in neurodegeneration.
Eacker SM, Dawson TM, Dawson VL., Nat Rev Neurosci 10(12), 2009
PMID: 19904280

50 References

Daten bereitgestellt von Europe PubMed Central.

Molecular mechanisms for activity-regulated protein synthesis in the synapto-dendritic compartment.
Wells DG, Richter JD, Fallon JR., Curr. Opin. Neurobiol. 10(1), 2000
PMID: 10679431
cAMP-GEFII is a direct target of cAMP in regulated exocytosis.
Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, Sunaga Y, Yano H, Matsuura Y, Iwanaga T, Takai Y, Seino S., Nat. Cell Biol. 2(11), 2000
PMID: 11056535
Local protein synthesis and its role in synapse-specific plasticity.
Martin KC, Barad M, Kandel ER., Curr. Opin. Neurobiol. 10(5), 2000
PMID: 11084321
Protein synthesis at synaptic sites on dendrites.
Steward O, Schuman EM., Annu. Rev. Neurosci. 24(), 2001
PMID: 11283313
Local translation of classes of mRNAs that are targeted to neuronal dendrites.
Eberwine J, Miyashiro K, Kacharmina JE, Job C., Proc. Natl. Acad. Sci. U.S.A. 98(13), 2001
PMID: 11416191
Dendritic spines: structure, dynamics and regulation.
Hering H, Sheng M., Nat. Rev. Neurosci. 2(12), 2001
PMID: 11733795
Structure and function of dendritic spines.
Nimchinsky EA, Sabatini BL, Svoboda K., Annu. Rev. Physiol. 64(), 2002
PMID: 11826272
Synaptic strength regulated by palmitate cycling on PSD-95.
El-Husseini Ael-D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll RA, Bredt DS., Cell 108(6), 2002
PMID: 11955437
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.
Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G., Proc. Natl. Acad. Sci. U.S.A. 101(1), 2003
PMID: 14691248
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
Meister G, Landthaler M, Dorsett Y, Tuschl T., RNA 10(3), 2004
PMID: 14970398
Structural basis of long-term potentiation in single dendritic spines.
Matsuzaki M, Honkura N, Ellis-Davies GC, Kasai H., Nature 429(6993), 2004
PMID: 15190253
Microarray analysis of microRNA expression in the developing mammalian brain.
Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR., Genome Biol. 5(9), 2004
PMID: 15345052
The functions of animal microRNAs.
Ambros V., Nature 431(7006), 2004
PMID: 15372042
Fast and effective prediction of microRNA/target duplexes.
Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R., RNA 10(10), 2004
PMID: 15383676
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression.
Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT., Nat. Genet. 36(10), 2004
PMID: 15361871
Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton.
Zito K, Knott G, Shepherd GM, Shenolikar S, Svoboda K., Neuron 44(2), 2004
PMID: 15473970
Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.
Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R., Science 284(5421), 1999
PMID: 10364548
Bidirectional activity-dependent morphological plasticity in hippocampal neurons.
Nagerl UV, Eberhorn N, Cambridge SB, Bonhoeffer T., Neuron 44(5), 2004
PMID: 15572108
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome.
Bagni C, Greenough WT., Nat. Rev. Neurosci. 6(5), 2005
PMID: 15861180
PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa.
Etournay R, El-Amraoui A, Bahloul A, Blanchard S, Roux I, Pezeron G, Michalski N, Daviet L, Hardelin JP, Legrain P, Petit C., J. Cell. Sci. 118(Pt 13), 2005
PMID: 15976448
Ubiquitin and protein turnover in synapse function.
Yi JJ, Ehlers MD., Neuron 47(5), 2005
PMID: 16129392
Synaptic protein degradation by the ubiquitin proteasome system.
Bingol B, Schuman EM., Curr. Opin. Neurobiol. 15(5), 2005
PMID: 16150592
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis.
Vo N, Klein ME, Varlamova O, Keller DM, Yamamoto T, Goodman RH, Impey S., Proc. Natl. Acad. Sci. U.S.A. 102(45), 2005
PMID: 16260724
Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila.
Ashraf SI, McLoon AL, Sclarsic SM, Kunes S., Cell 124(1), 2006
PMID: 16413491
A brain-specific microRNA regulates dendritic spine development.
Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, Greenberg ME., Nature 439(7074), 2006
PMID: 16421561
Molecular mechanisms of dendritic spine morphogenesis.
Tada T, Sheng M., Curr. Opin. Neurobiol. 16(1), 2005
PMID: 16361095
Distinct roles for ephrinB3 in the formation and function of hippocampal synapses.
Rodenas-Ruano A, Perez-Pinzon MA, Green EJ, Henkemeyer M, Liebl DJ., Dev. Biol. 292(1), 2006
PMID: 16466709
Post-transcriptional regulation of microRNA expression.
Obernosterer G, Leuschner PJ, Alenius M, Martinez J., RNA 12(7), 2006
PMID: 16738409
RNAhybrid: microRNA target prediction easy, fast and flexible.
Kruger J, Rehmsmeier M., Nucleic Acids Res. 34(Web Server issue), 2006
PMID: 16845047
Neuronal RNA granules: movers and makers.
Kiebler MA, Bassell GJ., Neuron 51(6), 2006
PMID: 16982415
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.
Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, Schmidt L, Chen WG, Lin Y, Savner E, Griffith EC, Hu L, Steen JA, Weitz CJ, Greenberg ME., Neuron 52(2), 2006
PMID: 17046689
The neuronal microRNA system.
Kosik KS., Nat. Rev. Neurosci. 7(12), 2006
PMID: 17115073
Palmitoylation: policing protein stability and traffic.
Linder ME, Deschenes RJ., Nat. Rev. Mol. Cell Biol. 8(1), 2007
PMID: 17183362
An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development.
Paradis S, Harrar DB, Lin Y, Koon AC, Hauser JL, Griffith EC, Zhu L, Brass LF, Chen C, Greenberg ME., Neuron 53(2), 2007
PMID: 17224404
Lim kinases, regulators of actin dynamics.
Bernard O., Int. J. Biochem. Cell Biol. 39(6), 2006
PMID: 17188549
Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections.
Obernosterer G, Martinez J, Alenius M., Nat Protoc 2(6), 2007
PMID: 17571058
Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR.
Kye MJ, Liu T, Levy SF, Xu NL, Groves BB, Bonneau R, Lao K, Kosik KS., RNA 13(8), 2007
PMID: 17592044
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
Filipowicz W, Bhattacharyya SN, Sonenberg N., Nat. Rev. Genet. 9(2), 2008
PMID: 18197166
Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain.
Lugli G, Torvik VI, Larson J, Smalheiser NR., J. Neurochem. 106(2), 2008
PMID: 18410515
Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.
Kang R, Wan J, Arstikaitis P, Takahashi H, Huang K, Bailey AO, Thompson JX, Roth AF, Drisdel RC, Mastro R, Green WN, Yates JR 3rd, Davis NG, El-Husseini A., Nature 456(7224), 2008
PMID: 19092927


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