Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene

Kamp P-B, Ragg H (1999)
GENE 229(1-2): 137-144.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
The genomic organization of the heparin cofactor II (HCII) gene from rat and mouse was investigated and compared with their human counterpart. The genes share a common core structure consisting of five exons interrupted by four introns, but the mouse and rat gene reveal individual additional features. A unique differentially spliced exon is present in the 5'-untranslated region of the rat gene, which most probably has arisen de novo by point mutations in intronic sequences of the ancestor gene. In the mouse HCII gene, a novel intron/exon boundary has been created due to the presence of an additional DNA segment, which simultaneously provides a 3'-splice site and a polypyrimidine stretch leading to an alternatively used exon of increased size. Our data suggest that, in contrast to most other mammalian genes, the exon/intron pattern of the gene coding for HCII is in dynamic evolution. (C) 1999 Elsevier Science B.V. All rights reserved.
Erscheinungsjahr
Zeitschriftentitel
GENE
Band
229
Ausgabe
1-2
Seite(n)
137-144
ISSN
PUB-ID

Zitieren

Kamp P-B, Ragg H. Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE. 1999;229(1-2):137-144.
Kamp, P. - B., & Ragg, H. (1999). Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE, 229(1-2), 137-144. doi:10.1016/S0378-1119(99)00036-0
Kamp, P. - B., and Ragg, H. (1999). Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE 229, 137-144.
Kamp, P.-B., & Ragg, H., 1999. Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE, 229(1-2), p 137-144.
P.-B. Kamp and H. Ragg, “Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene”, GENE, vol. 229, 1999, pp. 137-144.
Kamp, P.-B., Ragg, H.: Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene. GENE. 229, 137-144 (1999).
Kamp, Paul-Bertram, and Ragg, Hermann. “Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene”. GENE 229.1-2 (1999): 137-144.

3 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes.
Ragg H, Kumar A, Köster K, Bentele C, Wang Y, Frese MA, Prib N, Krüger O., BMC Evol Biol 9(), 2009
PMID: 19698129
Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice.
Aihara K, Azuma H, Akaike M, Ikeda Y, Sata M, Takamori N, Yagi S, Iwase T, Sumitomo Y, Kawano H, Yamada T, Fukuda T, Matsumoto T, Sekine K, Sato T, Nakamichi Y, Yamamoto Y, Yoshimura K, Watanabe T, Nakamura T, Oomizu A, Tsukada M, Hayashi H, Sudo T, Kato S, Matsumoto T., J Clin Invest 117(6), 2007
PMID: 17549254

25 References

Daten bereitgestellt von Europe PubMed Central.


Ausubel, 1992
Regional localization of over 300 loci on human chromosome 22 using a somatic cell hybrid mapping panel.
Budarf ML, Eckman B, Michaud D, McDonald T, Gavigan S, Buetow KH, Tatsumura Y, Liu Z, Hilliard C, Driscoll D, Goldmuntz E, Meese E, Zwarthoff EC, Williams S, McDermid H, Dumanski JP, Biegel J, Bell CJ, Emanuel BS., Genomics 35(2), 1996
PMID: 8661140
A high density YAC contig map of human chromosome 22
Collins, Nature 377(Suppl. 6547), 1995
Splice junctions: association with variation in protein structure.
Craik CS, Rutter WJ, Fletterick R., Science 220(4602), 1983
PMID: 6344214
Did the ancestral globin gene of plants and animals contain only two introns?
Dixon B, Pohajdak B., Trends Biochem. Sci. 17(12), 1992
PMID: 1471256
Complete nucleotide sequence of the gene for human heparin cofactor II and mapping to chromosomal band 22q11.
Herzog R, Lutz S, Blin N, Marasa JC, Blinder MA, Tollefsen DM., Biochemistry 30(5), 1991
PMID: 1671335
Organization of the human alpha 2-plasmin inhibitor gene.
Hirosawa S, Nakamura Y, Miura O, Sumi Y, Aoki N., Proc. Natl. Acad. Sci. U.S.A. 85(18), 1988
PMID: 3166140
Integration of retroposable elements in mammals: selection of target sites.
Jurka J, Klonowski P., J. Mol. Evol. 43(6), 1996
PMID: 8995066
A molecular timescale for vertebrate evolution.
Kumar S, Hedges SB., Nature 392(6679), 1998
PMID: 9582070
Long-range mapping and construction of a YAC contig within the cat eye syndrome critical region.
McDermid HE, McTaggart KE, Riazi MA, Hudson TJ, Budarf ML, Emanuel BS, Bell CJ., Genome Res. 6(12), 1996
PMID: 8973909
Microdeletion 22q11 in complex cardiovascular malformations.
Mehraein Y, Wippermann CF, Michel-Behnke I, Nhan Ngo TK, Hillig U, Giersberg M, Aulepp U, Barth H, Fritz B, Rehder H., Hum. Genet. 99(4), 1997
PMID: 9099830
Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family
Nishio, Proc. Natl. Acad. Sci. USA 93(), 1996
The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
Potempa J, Korzus E, Travis J., J. Biol. Chem. 269(23), 1994
PMID: 8206889
Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.
Puech A, Saint-Jore B, Funke B, Gilbert DJ, Sirotkin H, Copeland NG, Jenkins NA, Kucherlapati R, Morrow B, Skoultchi AI., Proc. Natl. Acad. Sci. U.S.A. 94(26), 1997
PMID: 9405660
Structure and expression of the gene coding for the human serpin hLS2.
Ragg H, Preibisch G., J. Biol. Chem. 263(24), 1988
PMID: 2841345
The ovalbumin family of serpin proteins.
Remold-O'Donnell E., FEBS Lett. 315(2), 1993
PMID: 8417965
Molecular cloning and expression of rabbit heparin cofactor II: a plasma thrombin inhibitor highly conserved between species
Sheffield, Thromb. Haemostas. 71(), 1994
Introns and higher-order structure in the evolution of serpins
Wright, J. Mol. Evol. 36(), 1993
Murine heparin cofactor II: purification, cDNA sequence, expression, and gene structure.
Zhang GS, Mehringer JH, Van Deerlin VM, Kozak CA, Tollefsen DM., Biochemistry 33(12), 1994
PMID: 7908224

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 10095113
PubMed | Europe PMC

Suchen in

Google Scholar