Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses

Ragg H, Lokot T, Kamp P-B, Atchley WR, Dress A (2001)
MOLECULAR BIOLOGY AND EVOLUTION 18(4): 577-584.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
A combination of three independent biological features, genomic organization, diagnostic amino acid sites, and rare indels, was used to elucidate the phylogeny of the vertebrate serpin (serine protease inhibitor) superfamily. A strong correlation between serpin gene families displaying (1) a conserved exon-intron pattern and (2) family-specific combinations of amino acid residues at specific sites suggests that present-day vertebrates encompass six serpin gene families which evolved from primordial genes by massive intron insertion before or during early vertebrate radiation. Introns placed at homologous positions in the gene sequences in combination with diagnostic sequence characters may also constitute a reliable kinship indicator for other protein superfamilies.
Stichworte
molecular evolution; serpins; diagnostic sites; exon-intron structure; heparin cofactor II
Erscheinungsjahr
2001
Zeitschriftentitel
MOLECULAR BIOLOGY AND EVOLUTION
Band
18
Ausgabe
4
Seite(n)
577-584
ISSN
0737-4038
Page URI
https://pub.uni-bielefeld.de/record/1617557

Zitieren

Ragg H, Lokot T, Kamp P-B, Atchley WR, Dress A. Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION. 2001;18(4):577-584.
Ragg, H., Lokot, T., Kamp, P. - B., Atchley, W. R., & Dress, A. (2001). Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION, 18(4), 577-584.
Ragg, H., Lokot, T., Kamp, P. - B., Atchley, W. R., and Dress, A. (2001). Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION 18, 577-584.
Ragg, H., et al., 2001. Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION, 18(4), p 577-584.
H. Ragg, et al., “Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses”, MOLECULAR BIOLOGY AND EVOLUTION, vol. 18, 2001, pp. 577-584.
Ragg, H., Lokot, T., Kamp, P.-B., Atchley, W.R., Dress, A.: Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses. MOLECULAR BIOLOGY AND EVOLUTION. 18, 577-584 (2001).
Ragg, Hermann, Lokot, Tatjana, Kamp, Paul-Bertram, Atchley, William R., and Dress, Andreas. “Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses”. MOLECULAR BIOLOGY AND EVOLUTION 18.4 (2001): 577-584.

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