Detection and manipulation of biomolecules by magnetic carriers

Brzeska M, Panhorst M, Kamp P-B, Schotter J, Reiss G, Pühler A, Becker A, Brückl H (2004)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Brzeska, M; Panhorst, MarenUniBi; Kamp, Paul-BertramUniBi; Schotter, Jörg; Reiss, GünterUniBi ; Pühler, AlfredUniBi ; Becker, Anke; Brückl, Hubert
Abstract / Bemerkung
The detection and manipulation of single molecules on a common platform would be of great interest for basic research of biological or chemical systems. A promising approach is the application of magnetic carriers. The principles are demonstrated in this contribution. It is shown that paramagnetic beads can be detected by highly sensitive magnetoresistive sensors yielding a purely electronic signal. Different configurations are discussed. The capability of the sensors to detect even single markers is demonstrated by a model experiment. In addition, the paramagnetic beads can be used as carriers for biomolecules. They can be manipulated on-chip via currents running through specially designed line patterns. Thus, magnetic markers in combination with magnetoresistive sensors are a promising choice for future integrated lab-on-a-chip systems. (C) 2004 Elsevier B.V. All rights reserved.
molecular recognition; biochip; marker; sensor; bonding force; magnetoresistive
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Brzeska M, Panhorst M, Kamp P-B, et al. Detection and manipulation of biomolecules by magnetic carriers. JOURNAL OF BIOTECHNOLOGY. 2004;112(1-2):25-33.
Brzeska, M., Panhorst, M., Kamp, P. - B., Schotter, J., Reiss, G., Pühler, A., Becker, A., et al. (2004). Detection and manipulation of biomolecules by magnetic carriers. JOURNAL OF BIOTECHNOLOGY, 112(1-2), 25-33.
Brzeska, M., Panhorst, M., Kamp, P. - B., Schotter, J., Reiss, G., Pühler, A., Becker, A., and Brückl, H. (2004). Detection and manipulation of biomolecules by magnetic carriers. JOURNAL OF BIOTECHNOLOGY 112, 25-33.
Brzeska, M., et al., 2004. Detection and manipulation of biomolecules by magnetic carriers. JOURNAL OF BIOTECHNOLOGY, 112(1-2), p 25-33.
M. Brzeska, et al., “Detection and manipulation of biomolecules by magnetic carriers”, JOURNAL OF BIOTECHNOLOGY, vol. 112, 2004, pp. 25-33.
Brzeska, M., Panhorst, M., Kamp, P.-B., Schotter, J., Reiss, G., Pühler, A., Becker, A., Brückl, H.: Detection and manipulation of biomolecules by magnetic carriers. JOURNAL OF BIOTECHNOLOGY. 112, 25-33 (2004).
Brzeska, M, Panhorst, Maren, Kamp, Paul-Bertram, Schotter, Jörg, Reiss, Günter, Pühler, Alfred, Becker, Anke, and Brückl, Hubert. “Detection and manipulation of biomolecules by magnetic carriers”. JOURNAL OF BIOTECHNOLOGY 112.1-2 (2004): 25-33.

21 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Magnetoimpedance Effect in the Ribbon-Based Patterned Soft Ferromagnetic Meander-Shaped Elements for Sensor Application.
Yang Z, Chlenova AA, Golubeva EV, Volchkov SO, Guo P, Shcherbinin SV, Kurlyandskaya GV., Sensors (Basel) 19(11), 2019
PMID: 31146498
Magnetic sensing platform technologies for biomedical applications.
Lin G, Makarov D, Schmidt OG., Lab Chip 17(11), 2017
PMID: 28485417
Electrochemical immunosensors for Salmonella detection in food.
Melo AM, Alexandre DL, Furtado RF, Borges MF, Figueiredo EA, Biswas A, Cheng HN, Alves CR., Appl Microbiol Biotechnol 100(12), 2016
PMID: 27138197
Giant Magnetoresistance: Basic Concepts, Microstructure, Magnetic Interactions and Applications.
Ennen I, Kappe D, Rempel T, Glenske C, Hütten A., Sensors (Basel) 16(6), 2016
PMID: 27322277
Simple and portable magnetic immunoassay for rapid detection and sensitive quantification of plant viruses.
Rettcher S, Jungk F, Kühn C, Krause HJ, Nölke G, Commandeur U, Fischer R, Schillberg S, Schröper F., Appl Environ Microbiol 81(9), 2015
PMID: 25710366
Magnetic nanoparticles for magnetoresistance-based biodetection.
Sun X, Ho D, Lacroix LM, Xiao JQ, Sun S., IEEE Trans Nanobioscience 11(1), 2012
PMID: 22157074
Non-linear magnetic behavior around zero field of an assembly of superparamagnetic nanoparticles.
de Montferrand C, Lalatonne Y, Bonnin D, Motte L, Monod P., Analyst 137(10), 2012
PMID: 22441242
X-ray phase contrast imaging of cell isolation with super-paramagnetic microbeads.
Tang R, Chai WM, Yang GY, Xie H, Chen KM., PLoS One 7(9), 2012
PMID: 23029126
Magnetic beads-assisted mild enrichment procedure for weak-binding lectins.
Totani K, Miyazawa H, Kurata S, Ito Y., Anal Biochem 411(1), 2011
PMID: 21184729
Magnetic nanoparticle biosensors.
Haun JB, Yoon TJ, Lee H, Weissleder R., Wiley Interdiscip Rev Nanomed Nanobiotechnol 2(3), 2010
PMID: 20336708
Magnetic biosensor technologies for medical applications: a review.
Llandro J, Palfreyman JJ, Ionescu A, Barnes CH., Med Biol Eng Comput 48(10), 2010
PMID: 20574723
Magnetic nanoparticles for biomedical NMR-based diagnostics.
Shao H, Yoon TJ, Liong M, Weissleder R, Lee H., Beilstein J Nanotechnol 1(), 2010
PMID: 21977404
Magnetoresistive immunosensor for the detection of Escherichia coli O157:H7 including a microfluidic network.
Mujika M, Arana S, Castaño E, Tijero M, Vilares R, Ruano-López JM, Cruz A, Sainz L, Berganza J., Biosens Bioelectron 24(5), 2009
PMID: 18760584
Magnetic labeling, detection, and system integration.
Tamanaha CR, Mulvaney SP, Rife JC, Whitman LJ., Biosens Bioelectron 24(1), 2008
PMID: 18374556
CRP determination based on a novel magnetic biosensor.
Meyer MH, Hartmann M, Krause HJ, Blankenstein G, Mueller-Chorus B, Oster J, Miethe P, Keusgen M., Biosens Bioelectron 22(6), 2007
PMID: 16766177
A SERRS-active bead/microelectromagnet system for small-scale sensitive molecular identification and quantitation.
Quinn EJ, Hernandez-Santana A, Hutson DM, Pegrum CM, Graham D, Smith WE., Small 3(8), 2007
PMID: 17492746
Sensitive bondforce measurements of ligand-receptor pairs with magnetic beads.
Panhorst M, Kamp PB, Reiss G, Brückl H., Biosens Bioelectron 20(8), 2005
PMID: 15626629
DNA-functionalized MFe2O4 (M = Fe, Co, or Mn) nanoparticles and their hybridization to DNA-functionalized surfaces.
Robinson DB, Persson HH, Zeng H, Li G, Pourmand N, Sun S, Wang SX., Langmuir 21(7), 2005
PMID: 15779990
Magnetic techniques for the isolation and purification of proteins and peptides.
Safarik I, Safarikova M., Biomagn Res Technol 2(1), 2004
PMID: 15566570

15 References

Daten bereitgestellt von Europe PubMed Central.

Giant magnetoresistance of (001)Fe/(001)Cr magnetic superlattices.
Baibich MN, Broto JM, Fert A, Nguyen Van Dau F , Petroff F, Etienne P, Creuzet G, Friederich A, Chazelas J., Phys. Rev. Lett. 61(21), 1988
PMID: 10039127
A biosensor based on magnetoresistance technology.
Baselt DR, Lee GU, Natesan M, Metzger SW, Sheehan PE, Colton RJ., Biosens Bioelectron 13(7-8), 1998
PMID: 9828367

Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: biotechnological applications
Graham, J. Appl. Phys. 91(), 2002
Layered magnetic structures: Evidence for antiferromagnetic coupling of Fe layers across Cr interlayers.
Grunberg P, Schreiber R, Pang Y, Brodsky MB, Sowers H., Phys. Rev. Lett. 57(19), 1986
PMID: 10033726

On-chip manipulation and magnetization assessment of magnetic bead ensembles by integrated spin-valve sensors
Lagae, J. Appl. Phys. 91(), 2002
Microelectromagnets for the control of magnetic nanoparticles
Lee, Appl. Phys. Lett. 79(), 2001
Large magnetoresistance at room temperature in ferromagnetic thin film tunnel junctions.
Moodera JS, Kinder LR, Wong TM, Meservey R., Phys. Rev. Lett. 74(16), 1995
PMID: 10058155

A biochip based on magnetoresistive sensors
Schotter, IEEE Trans. Magn. 38(), 2002
Comparison of a prototype magnetoresistive biosensor to standard fluorescent DNA detection.
Schotter J, Kamp PB, Becker A, Puhler A, Reiss G, Bruckl H., Biosens Bioelectron 19(10), 2004
PMID: 15046745
Aluminum oxidation by a remote electron cyclotron resonance plasma in magnetic tunnel junctions
Thomas, J. Vacuum Sci. Technol. B 21(), 2003
Model for detection of immobilized superparamagnetic nanosphere assay labels using giant magnetoresistive sensors
Tondra, J. Vacuum Sci. Technol. A 18(), 1999



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