AUDENS: A tool for automated peptide de novo sequencing

Grossmann J, Roos FF, Cieliebak M, Lipták Z, Mathis LK, Müller M, Gruissem W, Baginsky S (2005)
Journal of Proteome Research 4(5): 1768-1774.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
We present AUDENS, a new platform-independent open source tool for automated de novo sequencing of peptides from MS/MS data. We implemented a dynamic programming algorithm and combined it with a flexible preprocessing module which is designed to distinguish between signal and other peaks. By applying a user-defined set of heuristics, AUDENS screens through the spectrum and assigns high relevance values to putative signal peaks. The algorithm constructs a sequence path through the MS/MS spectrum using the peak relevances to score each suggested sequence path, i.e., the corresponding amino acid sequence. At present, we consider AUDENS a prototype that unfolds its biggest potential if used in parallel with other de novo sequencing tools. AUDENS is available open source and can be downloaded with further documentation at http://www.ti.inf.ethz.ch/pw/software/audens/.
Stichworte
de novo sequencing; spectra preprocessing; mass spectrometry
Erscheinungsjahr
2005
Zeitschriftentitel
Journal of Proteome Research
Band
4
Ausgabe
5
Seite(n)
1768-1774
ISSN
1535-3893
eISSN
1535-3907
Page URI
https://pub.uni-bielefeld.de/record/1601941

Zitieren

Grossmann J, Roos FF, Cieliebak M, et al. AUDENS: A tool for automated peptide de novo sequencing. Journal of Proteome Research. 2005;4(5):1768-1774.
Grossmann, J., Roos, F. F., Cieliebak, M., Lipták, Z., Mathis, L. K., Müller, M., Gruissem, W., et al. (2005). AUDENS: A tool for automated peptide de novo sequencing. Journal of Proteome Research, 4(5), 1768-1774. doi:10.1021/pr050070a
Grossmann, J., Roos, F. F., Cieliebak, M., Lipták, Z., Mathis, L. K., Müller, M., Gruissem, W., and Baginsky, S. (2005). AUDENS: A tool for automated peptide de novo sequencing. Journal of Proteome Research 4, 1768-1774.
Grossmann, J., et al., 2005. AUDENS: A tool for automated peptide de novo sequencing. Journal of Proteome Research, 4(5), p 1768-1774.
J. Grossmann, et al., “AUDENS: A tool for automated peptide de novo sequencing”, Journal of Proteome Research, vol. 4, 2005, pp. 1768-1774.
Grossmann, J., Roos, F.F., Cieliebak, M., Lipták, Z., Mathis, L.K., Müller, M., Gruissem, W., Baginsky, S.: AUDENS: A tool for automated peptide de novo sequencing. Journal of Proteome Research. 4, 1768-1774 (2005).
Grossmann, Jonas, Roos, Franz F., Cieliebak, Mark, Lipták, Zsuzsanna, Mathis, Lukas K., Müller, Matthias, Gruissem, Wilhelm, and Baginsky, Sacha. “AUDENS: A tool for automated peptide de novo sequencing”. Journal of Proteome Research 4.5 (2005): 1768-1774.

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PMID: 16212431
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