Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1

Jakoby MJ, Weinl C, Pusch S, Kuijt SJH, Merkle T, Dissmeyer N, Schnittger A (2006)
Plant Physiology 141(4): 1293-1305.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Recent studies have shown that cyclin-dependent kinase (CDK) inhibitors can have a tremendous impact on cell cycle progression in plants. In animals, CDK inhibitors are tightly regulated, especially by posttranslational mechanisms of which control of nuclear access and regulation of protein turnover are particularly important. Here we address the posttranslational regulation of INHIBITOR/INTERACTOR OF CDK 1 (ICK1)/KIP RELATED PROTEIN 1 ( KRP1), an Arabidopsis ( Arabidopsis thaliana) CDK inhibitor. We show that ICK1/KRP1 exerts its function in the nucleus and its presence in the nucleus is controlled by multiple nuclear localization signals as well as by nuclear export. In addition, we show that ICK1/KRP1 localizes to different subnuclear domains, i.e. in the nucleoplasm and to the chromocenters, hinting at specific actions within the nuclear compartment. Localization to the chromocenters is mediated by an N-terminal domain, in addition we find that this domain may be involved in cyclin binding. Further we demonstrate that ICK1/KRP1 is an unstable protein and degraded by the 26S proteasome in the nucleus. This degradation is mediated by at least two domains indicating the presence of at least two different pathways impinging on ICK1/KRP1 protein stability.
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Plant Physiology
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141
Ausgabe
4
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1293-1305
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Jakoby MJ, Weinl C, Pusch S, et al. Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1. Plant Physiology. 2006;141(4):1293-1305.
Jakoby, M. J., Weinl, C., Pusch, S., Kuijt, S. J. H., Merkle, T., Dissmeyer, N., & Schnittger, A. (2006). Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1. Plant Physiology, 141(4), 1293-1305. doi:10.1104/pp.106.081406
Jakoby, M. J., Weinl, C., Pusch, S., Kuijt, S. J. H., Merkle, T., Dissmeyer, N., and Schnittger, A. (2006). Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1. Plant Physiology 141, 1293-1305.
Jakoby, M.J., et al., 2006. Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1. Plant Physiology, 141(4), p 1293-1305.
M.J. Jakoby, et al., “Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1”, Plant Physiology, vol. 141, 2006, pp. 1293-1305.
Jakoby, M.J., Weinl, C., Pusch, S., Kuijt, S.J.H., Merkle, T., Dissmeyer, N., Schnittger, A.: Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1. Plant Physiology. 141, 1293-1305 (2006).
Jakoby, Marc J., Weinl, Christina, Pusch, Stefan, Kuijt, Suzanne J. H., Merkle, Thomas, Dissmeyer, Nico, and Schnittger, Arp. “Analysis of the subcellular localization, function, and proteolytic control of the Arabidopsis cyclin-dependent kinase inhibitor ICK1/KRP1”. Plant Physiology 141.4 (2006): 1293-1305.

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Daten bereitgestellt von Europe PubMed Central.

Multiple mechanisms explain how reduced KRP expression increases leaf size of Arabidopsis thaliana.
Sizani BL, Kalve S, Markakis MN, Domagalska MA, Stelmaszewska J, AbdElgawad H, Zhao X, De Veylder L, De Vos D, Broeckhove J, Schnittger A, Beemster GTS., New Phytol 221(3), 2019
PMID: 30267580
SIAMESE-RELATED1 Is Regulated Posttranslationally and Participates in Repression of Leaf Growth under Moderate Drought.
Dubois M, Selden K, Bediée A, Rolland G, Baumberger N, Noir S, Bach L, Lamy G, Granier C, Genschik P., Plant Physiol 176(4), 2018
PMID: 29472278
Arabidopsis ICK/KRP cyclin-dependent kinase inhibitors function to ensure the formation of one megaspore mother cell and one functional megaspore per ovule.
Cao L, Wang S, Venglat P, Zhao L, Cheng Y, Ye S, Qin Y, Datla R, Zhou Y, Wang H., PLoS Genet 14(3), 2018
PMID: 29513662
Functional Analysis of Short Linear Motifs in the Plant Cyclin-Dependent Kinase Inhibitor SIAMESE.
Kumar N, Dale R, Kemboi D, Zeringue EA, Kato N, Larkin JC., Plant Physiol 177(4), 2018
PMID: 29903833
Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants.
Coelho RR, Vieira P, Antonino de Souza Júnior JD, Martin-Jimenez C, De Veylder L, Cazareth J, Engler G, Grossi-de-Sa MF, de Almeida Engler J., Plant Cell Environ 40(7), 2017
PMID: 28103637
Two maize Kip-related proteins differentially interact with, inhibit and are phosphorylated by cyclin D-cyclin-dependent kinase complexes.
Godínez-Palma SK, Rosas-Bringas FR, Rosas-Bringas OG, García-Ramírez E, Zamora-Zaragoza J, Vázquez-Ramos JM., J Exp Bot 68(7), 2017
PMID: 28369656
Identification and functional analysis of the ICK gene family in maize.
Xiao Q, Zhang C, Li H, Wei B, Wang Y, Huang H, Li Y, Yu G, Liu H, Zhang J, Liu Y, Hu Y, Huang Y., Sci Rep 7(), 2017
PMID: 28262730
Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone.
Bunk EC, Ertaylan G, Ortega F, Pavlou MA, Gonzalez Cano L, Stergiopoulos A, Safaiyan S, Völs S, van Cann M, Politis PK, Simons M, Berninger B, Del Sol A, Schwamborn JC., Stem Cells 34(8), 2016
PMID: 27068685
Phenotypes on demand via switchable target protein degradation in multicellular organisms.
Faden F, Ramezani T, Mielke S, Almudi I, Nairz K, Froehlich MS, Höckendorff J, Brandt W, Hoehenwarter W, Dohmen RJ, Schnittger A, Dissmeyer N., Nat Commun 7(), 2016
PMID: 27447739
A zinc finger motif-containing protein is essential for chloroplast RNA editing.
Sun T, Shi X, Friso G, Van Wijk K, Bentolila S, Hanson MR., PLoS Genet 11(3), 2015
PMID: 25768119
β-Carboxysomal proteins assemble into highly organized structures in Nicotiana chloroplasts.
Lin MT, Occhialini A, Andralojc PJ, Devonshire J, Hines KM, Parry MA, Hanson MR., Plant J 79(1), 2014
PMID: 24810513
Cell cycle control and seed development.
Dante RA, Larkins BA, Sabelli PA., Front Plant Sci 5(), 2014
PMID: 25295050
Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
Matos JL, Lau OS, Hachez C, Cruz-Ramírez A, Scheres B, Bergmann DC., Elife 3(), 2014
PMID: 25303364
Multiple functions of Kip-related protein5 connect endoreduplication and cell elongation.
Jégu T, Latrasse D, Delarue M, Mazubert C, Bourge M, Hudik E, Blanchet S, Soler MN, Charon C, De Veylder L, Raynaud C, Bergounioux C, Benhamed M., Plant Physiol 161(4), 2013
PMID: 23426196
An RNA recognition motif-containing protein is required for plastid RNA editing in Arabidopsis and maize.
Sun T, Germain A, Giloteaux L, Hammani K, Barkan A, Hanson MR, Bentolila S., Proc Natl Acad Sci U S A 110(12), 2013
PMID: 23487777
Arabidopsis phosphoglycerate dehydrogenase1 of the phosphoserine pathway is essential for development and required for ammonium assimilation and tryptophan biosynthesis.
Benstein RM, Ludewig K, Wulfert S, Wittek S, Gigolashvili T, Frerigmann H, Gierth M, Flügge UI, Krueger S., Plant Cell 25(12), 2013
PMID: 24368794
Identification of kinase substrates by bimolecular complementation assays.
Pusch S, Harashima H, Schnittger A., Plant J 70(2), 2012
PMID: 22098373
A general G1/S-phase cell-cycle control module in the flowering plant Arabidopsis thaliana.
Zhao X, Harashima H, Dissmeyer N, Pusch S, Weimer AK, Bramsiepe J, Bouyer D, Rademacher S, Nowack MK, Novak B, Sprunck S, Schnittger A., PLoS Genet 8(8), 2012
PMID: 22879821
Nucleo-cytoplasmic transport of proteins and RNA in plants.
Merkle T., Plant Cell Rep 30(2), 2011
PMID: 20960203
Two differentially expressed MATE factor genes from apple complement the Arabidopsis transparent testa12 mutant.
Frank S, Keck M, Sagasser M, Niehaus K, Weisshaar B, Stracke R., Plant Biol (Stuttg) 13(1), 2011
PMID: 21143724
The Arabidopsis D-type cyclin CYCD2;1 and the inhibitor ICK2/KRP2 modulate auxin-induced lateral root formation.
Sanz L, Dewitte W, Forzani C, Patell F, Nieuwland J, Wen B, Quelhas P, De Jager S, Titmus C, Campilho A, Ren H, Estelle M, Wang H, Murray JA., Plant Cell 23(2), 2011
PMID: 21357490
Arabidopsis G1 cell cycle proteins undergo proteasome-dependent degradation during sucrose starvation.
Hirano H, Shinmyo A, Sekine M., Plant Physiol Biochem 49(6), 2011
PMID: 21444209
The Arabidopsis ESCRT protein-protein interaction network.
Shahriari M, Richter K, Keshavaiah C, Sabovljevic A, Huelskamp M, Schellmann S., Plant Mol Biol 76(1-2), 2011
PMID: 21442383
Plant reproduction: does size matter?
Nieuwland J, de Graaf BH, Cheung AY, Bosch M., New Phytol 190(4), 2011
PMID: 21561456
Identification of the Arabidopsis REDUCED DORMANCY 2 gene uncovers a role for the polymerase associated factor 1 complex in seed dormancy.
Liu Y, Geyer R, van Zanten M, Carles A, Li Y, Hörold A, van Nocker S, Soppe WJ., PLoS One 6(7), 2011
PMID: 21799800
Nuclear protein kinases: still enigmatic components in plant cell signalling.
Dahan J, Wendehenne D, Ranjeva R, Pugin A, Bourque S., New Phytol 185(2), 2010
PMID: 19925553
Variability in the control of cell division underlies sepal epidermal patterning in Arabidopsis thaliana.
Roeder AH, Chickarmane V, Cunha A, Obara B, Manjunath BS, Meyerowitz EM., PLoS Biol 8(5), 2010
PMID: 20485493
Endoreplication controls cell fate maintenance.
Bramsiepe J, Wester K, Weinl C, Roodbarkelari F, Kasili R, Larkin JC, Hülskamp M, Schnittger A., PLoS Genet 6(6), 2010
PMID: 20585618
Functional characterization of the tomato cyclin-dependent kinase inhibitor SlKRP1 domains involved in protein-protein interactions.
Nafati M, Frangne N, Hernould M, Chevalier C, Gévaudant F., New Phytol 188(1), 2010
PMID: 20618916
Cullin 4-ring finger-ligase plays a key role in the control of endoreplication cycles in Arabidopsis trichomes.
Roodbarkelari F, Bramsiepe J, Weinl C, Marquardt S, Novák B, Jakoby MJ, Lechner E, Genschik P, Schnittger A., Proc Natl Acad Sci U S A 107(34), 2010
PMID: 20696906
The AAA-type ATPase AtSKD1 contributes to vacuolar maintenance of Arabidopsis thaliana.
Shahriari M, Keshavaiah C, Scheuring D, Sabovljevic A, Pimpl P, Häusler RE, Hülskamp M, Schellmann S., Plant J 64(1), 2010
PMID: 20663085
Selective proteolysis sets the tempo of the cell cycle.
Marrocco K, Bergdoll M, Achard P, Criqui MC, Genschik P., Curr Opin Plant Biol 13(6), 2010
PMID: 20810305
RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle.
Lai J, Chen H, Teng K, Zhao Q, Zhang Z, Li Y, Liang L, Xia R, Wu Y, Guo H, Xie Q., Plant J 57(5), 2009
PMID: 19000158
The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development.
Gusti A, Baumberger N, Nowack M, Pusch S, Eisler H, Potuschak T, De Veylder L, Schnittger A, Genschik P., PLoS One 4(3), 2009
PMID: 19277118
Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1.
Dissmeyer N, Weimer AK, Pusch S, De Schutter K, Alvim Kamei CL, Nowack MK, Novak B, Duan GL, Zhu YG, De Veylder L, Schnittger A., Plant Cell 21(11), 2009
PMID: 19948791
Degradation of the cyclin-dependent kinase inhibitor KRP1 is regulated by two different ubiquitin E3 ligases.
Ren H, Santner A, del Pozo JC, Murray JA, Estelle M., Plant J 53(5), 2008
PMID: 18005227
Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell cycle progression during Arabidopsis gametogenesis.
Liu J, Zhang Y, Qin G, Tsuge T, Sakaguchi N, Luo G, Sun K, Shi D, Aki S, Zheng N, Aoyama T, Oka A, Yang W, Umeda M, Xie Q, Gu H, Qu LJ., Plant Cell 20(6), 2008
PMID: 18552199
Transcriptional profiling of mature Arabidopsis trichomes reveals that NOECK encodes the MIXTA-like transcriptional regulator MYB106.
Jakoby MJ, Falkenhan D, Mader MT, Brininstool G, Wischnitzki E, Platz N, Hudson A, Hülskamp M, Larkin J, Schnittger A., Plant Physiol 148(3), 2008
PMID: 18805951
The plant CDK inhibitor NtKIS1a interferes with dedifferentiation, is specifically down regulated during development and interacts with a JAB1 homolog
Le Foll Marion, Blanchet Sophie, Millan Laurine, Mathieu Chantal, Bergounioux Catherine, Glab Nathalie., Plant Sci 175(4), 2008
PMID: IND44095782
T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue.
Dissmeyer N, Nowack MK, Pusch S, Stals H, Inzé D, Grini PE, Schnittger A., Plant Cell 19(3), 2007
PMID: 17369369

48 References

Daten bereitgestellt von Europe PubMed Central.

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.
Kamura T, Hara T, Matsumoto M, Ishida N, Okumura F, Hatakeyama S, Yoshida M, Nakayama K, Nakayama KI., Nat. Cell Biol. 6(12), 2004
PMID: 15531880
Caspases: the executioners of apoptosis.
Cohen GM., Biochem. J. 326 ( Pt 1)(), 1997
PMID: 9337844
PI3K-Akt pathway: its functions and alterations in human cancer.
Osaki M, Oshimura M, Ito H., Apoptosis 9(6), 2004
PMID: 15505410
Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation.
Walter M, Chaban C, Schutze K, Batistic O, Weckermann K, Nake C, Blazevic D, Grefen C, Schumacher K, Oecking C, Harter K, Kudla J., Plant J. 40(3), 2004
PMID: 15469500
14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).
Sekimoto T, Fukumoto M, Yoneda Y., EMBO J. 23(9), 2004
PMID: 15057270
p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus.
Yokoo T, Toyoshima H, Miura M, Wang Y, Iida KT, Suzuki H, Sone H, Shimano H, Gotoda T, Nishimori S, Tanaka K, Yamada N., J. Biol. Chem. 278(52), 2003
PMID: 14530263
The spindle assembly and spindle position checkpoints.
Lew DJ, Burke DJ., Annu. Rev. Genet. 37(), 2003
PMID: 14616062
Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.
Liang J, Slingerland JM., Cell Cycle 2(4), 2003
PMID: 12851486
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.
Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM., Mol. Biol. Cell 14(1), 2003
PMID: 12529437
Role of a positive regulator of root hair development, CAPRICE, in Arabidopsis root epidermal cell differentiation.
Wada T, Kurata T, Tominaga R, Koshino-Kimura Y, Tachibana T, Goto K, Marks MD, Shimura Y, Okada K., Development 129(23), 2002
PMID: 12403712
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M., Nat. Med. 8(10), 2002
PMID: 12244303
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
Fujita N, Sato S, Katayama K, Tsuruo T., J. Biol. Chem. 277(32), 2002
PMID: 12042314
Control of stomatal distribution on the Arabidopsis leaf surface.
Nadeau JA, Sack FD., Science 296(5573), 2002
PMID: 12040198
Ectopic D-type cyclin expression induces not only DNA replication but also cell division in Arabidopsis trichomes.
Schnittger A, Schobinger U, Bouyer D, Weinl C, Stierhof YD, Hulskamp M., Proc. Natl. Acad. Sci. U.S.A. 99(9), 2002
PMID: 11983922
Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export.
Ishida N, Hara T, Kamura T, Yoshida M, Nakayama K, Nakayama KI., J. Biol. Chem. 277(17), 2002
PMID: 11889117
Dynamic recruitment of Cdc2 to specific microtubule structures during mitosis.
Weingartner M, Binarova P, Drykova D, Schweighofer A, David JP, Heberle-Bors E, Doonan J, Bogre L., Plant Cell 13(8), 2001
PMID: 11487703
Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis.
De Veylder L, Beeckman T, Beemster GT, Krols L, Terras F, Landrieu I, van der Schueren E, Maes S, Naudts M, Inze D., Plant Cell 13(7), 2001
PMID: 11449057
Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1.
Nakayama KI, Hatakeyama S, Nakayama K., Biochem. Biophys. Res. Commun. 282(4), 2001
PMID: 11352628
Finding nuclear localization signals.
Cokol M, Nair R, Rost B., EMBO Rep. 1(5), 2000
PMID: 11258480
Integrated cytogenetic map of chromosome arm 4S of A. thaliana: structural organization of heterochromatic knob and centromere region.
Fransz PF, Armstrong S, de Jong JH, Parnell LD, van Drunen C, Dean C, Zabel P, Bisseling T, Jones GH., Cell 100(3), 2000
PMID: 10676818
Transport between the cell nucleus and the cytoplasm.
Gorlich D, Kutay U., Annu. Rev. Cell Dev. Biol. 15(), 1999
PMID: 10611974
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
Carrano AC, Eytan E, Hershko A, Pagano M., Nat. Cell Biol. 1(4), 1999
PMID: 10559916
Four-dimensional control of the cell cycle.
Pines J., Nat. Cell Biol. 1(3), 1999
PMID: 10559915
The Arabidopsis genome encodes structurally and functionally diverse HMGB-type proteins.
Grasser M, Lentz A, Lichota J, Merkle T, Grasser KD., J. Mol. Biol. 358(3), 2006
PMID: 16563436
Activation of an alfalfa cyclin-dependent kinase inhibitor by calmodulin-like domain protein kinase.
Pettko-Szandtner A, Meszaros T, Horvath GV, Bako L, Csordas-Toth E, Blastyak A, Zhiponova M, Miskolczi P, Dudits D., Plant J. 46(1), 2006
PMID: 16553899
Cyclin-dependent kinase (CDK) inhibitors regulate the CDK-cyclin complex activities in endoreduplicating cells of developing tomato fruit.
Bisbis B, Delmas F, Joubes J, Sicard A, Hernould M, Inze D, Mouras A, Chevalier C., J. Biol. Chem. 281(11), 2006
PMID: 16407228
A positive signal from the fertilization of the egg cell sets off endosperm proliferation in angiosperm embryogenesis.
Nowack MK, Grini PE, Jakoby MJ, Lafos M, Koncz C, Schnittger A., Nat. Genet. 38(1), 2005
PMID: 16311592
Kinetochore structure and function.
Chan GK, Liu ST, Yen TJ., Trends Cell Biol. 15(11), 2005
PMID: 16214339
Switching the cell cycle. Kip-related proteins in plant cell cycle control.
Verkest A, Weinl C, Inze D, De Veylder L, Schnittger A., Plant Physiol. 139(3), 2005
PMID: 16286449
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.
Hao B, Zheng N, Schulman BA, Wu G, Miller JJ, Pagano M, Pavletich NP., Mol. Cell 20(1), 2005
PMID: 16209941
Cyclin-dependent kinase inhibitors in maize endosperm and their potential role in endoreduplication.
Coelho CM, Dante RA, Sabelli PA, Sun Y, Dilkes BP, Gordon-Kamm WJ, Larkins BA., Plant Physiol. 138(4), 2005
PMID: 16055680
Nucleocytoplasmic trafficking in plant cells.
Meier I., Int. Rev. Cytol. 244(), 2005
PMID: 16157179
The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes.
Verkest A, Manes CL, Vercruysse S, Maes S, Van Der Schueren E, Beeckman T, Genschik P, Kuiper M, Inze D, De Veylder L., Plant Cell 17(6), 2005
PMID: 15863515
Novel functions of plant cyclin-dependent kinase inhibitors, ICK1/KRP1, can act non-cell-autonomously and inhibit entry into mitosis.
Weinl C, Marquardt S, Kuijt SJ, Nowack MK, Jakoby MJ, Hulskamp M, Schnittger A., Plant Cell 17(6), 2005
PMID: 15749764
Mechanisms of receptor-mediated nuclear import and nuclear export.
Pemberton LF, Paschal BM., Traffic 6(3), 2005
PMID: 15702987
Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer.
Rosen DG, Yang G, Cai KQ, Bast RC Jr, Gershenson DM, Silva EG, Liu J., Clin. Cancer Res. 11(2 Pt 1), 2005
PMID: 15701850
A second RING to destroy p27(Kip1).
Hengst L., Nat. Cell Biol. 6(12), 2004
PMID: 15573093

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