Interferon-beta modulates protein synthesis in the central nervous system

Beyer S, Raether G, Stadler K, Hoffrogge R, Scharf C, Rolfs A, Mix E, Strauss U (2009)
JOURNAL OF NEUROIMMUNOLOGY 213(1-2): 31-38.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Interferon-beta (IFN-beta), acting canonically via the modulation of transcription, affects neocortical pyramidal neurons. By use of 2-D differential gel electrophoresis and subsequent mass spectrometry we identified IFN-beta regulated proteins in the central nervous system. These proteins are involved in cytoskeleton assembly, protein transport and nucleotide metabolism and, as such, serve regenerative and protective functions. Electrophysiologically, IFN-beta mediated protein synthesis is essential for part of the excitatory neuronal effects, as revealed under blockade of protein biosynthesis. This study presents novel effects of IFN-beta in the central nervous system and begins to unravel the mechanism behind the known excitability changes in neurons. (C) 2009 Elsevier B.V. All rights reserved.
Stichworte
Mass spectrometry; Cycloheximide; Intracellular recordings; Cortical; neurons; Cytokines
Erscheinungsjahr
2009
Zeitschriftentitel
JOURNAL OF NEUROIMMUNOLOGY
Band
213
Ausgabe
1-2
Seite(n)
31-38
ISSN
0165-5728
Page URI
https://pub.uni-bielefeld.de/record/1590965

Zitieren

Beyer S, Raether G, Stadler K, et al. Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY. 2009;213(1-2):31-38.
Beyer, S., Raether, G., Stadler, K., Hoffrogge, R., Scharf, C., Rolfs, A., Mix, E., et al. (2009). Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY, 213(1-2), 31-38. doi:10.1016/j.jneuroim.2009.06.004
Beyer, S., Raether, G., Stadler, K., Hoffrogge, R., Scharf, C., Rolfs, A., Mix, E., and Strauss, U. (2009). Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY 213, 31-38.
Beyer, S., et al., 2009. Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY, 213(1-2), p 31-38.
S. Beyer, et al., “Interferon-beta modulates protein synthesis in the central nervous system”, JOURNAL OF NEUROIMMUNOLOGY, vol. 213, 2009, pp. 31-38.
Beyer, S., Raether, G., Stadler, K., Hoffrogge, R., Scharf, C., Rolfs, A., Mix, E., Strauss, U.: Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY. 213, 31-38 (2009).
Beyer, Susanne, Raether, Gergana, Stadler, Konstantin, Hoffrogge, Raimund, Scharf, Christian, Rolfs, Arndt, Mix, Eilhard, and Strauss, Ulf. “Interferon-beta modulates protein synthesis in the central nervous system”. JOURNAL OF NEUROIMMUNOLOGY 213.1-2 (2009): 31-38.

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