Interferon-beta modulates protein synthesis in the central nervous system

Beyer, Susanne; Raether, Gergana; Stadler, Konstantin; Hoffrogge, Raimund; Scharf, Christian; Rolfs, Arndt; Mix, Eilhard; Strauss, Ulf

Interferon-beta modulates protein synthesis in the central nervous system

Beyer S, Raether G, Stadler K, Hoffrogge R, Scharf C, Rolfs A, Mix E, Strauss U (2009)
JOURNAL OF NEUROIMMUNOLOGY 213(1-2): 31-38.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.1016/j.jneuroim.2009.06.004

Autor*in

Beyer, Susanne; Raether, Gergana; Stadler, Konstantin; Hoffrogge, Raimund^UniBi ; Scharf, Christian; Rolfs, Arndt; Mix, Eilhard; Strauss, Ulf

Einrichtung

Technische Fakultät

Abstract / Bemerkung

Interferon-beta (IFN-beta), acting canonically via the modulation of transcription, affects neocortical pyramidal neurons. By use of 2-D differential gel electrophoresis and subsequent mass spectrometry we identified IFN-beta regulated proteins in the central nervous system. These proteins are involved in cytoskeleton assembly, protein transport and nucleotide metabolism and, as such, serve regenerative and protective functions. Electrophysiologically, IFN-beta mediated protein synthesis is essential for part of the excitatory neuronal effects, as revealed under blockade of protein biosynthesis. This study presents novel effects of IFN-beta in the central nervous system and begins to unravel the mechanism behind the known excitability changes in neurons. (C) 2009 Elsevier B.V. All rights reserved.

Stichworte

Mass spectrometry; Cycloheximide; Intracellular recordings; Cortical; neurons; Cytokines

Erscheinungsjahr

2009

Zeitschriftentitel

JOURNAL OF NEUROIMMUNOLOGY

Band

213

Ausgabe

1-2

Seite(n)

31-38

ISSN

0165-5728

Page URI

https://pub.uni-bielefeld.de/record/1590965

Zitieren

Beyer S, Raether G, Stadler K, et al. Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY. 2009;213(1-2):31-38.

Beyer, S., Raether, G., Stadler, K., Hoffrogge, R., Scharf, C., Rolfs, A., Mix, E., et al. (2009). Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY, 213(1-2), 31-38. https://doi.org/10.1016/j.jneuroim.2009.06.004

Beyer, Susanne, Raether, Gergana, Stadler, Konstantin, Hoffrogge, Raimund, Scharf, Christian, Rolfs, Arndt, Mix, Eilhard, and Strauss, Ulf. 2009. “Interferon-beta modulates protein synthesis in the central nervous system”. JOURNAL OF NEUROIMMUNOLOGY 213 (1-2): 31-38.

Beyer, S., Raether, G., Stadler, K., Hoffrogge, R., Scharf, C., Rolfs, A., Mix, E., and Strauss, U. (2009). Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY 213, 31-38.

Beyer, S., et al., 2009. Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY, 213(1-2), p 31-38.

S. Beyer, et al., “Interferon-beta modulates protein synthesis in the central nervous system”, JOURNAL OF NEUROIMMUNOLOGY, vol. 213, 2009, pp. 31-38.

Beyer, S., Raether, G., Stadler, K., Hoffrogge, R., Scharf, C., Rolfs, A., Mix, E., Strauss, U.: Interferon-beta modulates protein synthesis in the central nervous system. JOURNAL OF NEUROIMMUNOLOGY. 213, 31-38 (2009).

Beyer, Susanne, Raether, Gergana, Stadler, Konstantin, Hoffrogge, Raimund, Scharf, Christian, Rolfs, Arndt, Mix, Eilhard, and Strauss, Ulf. “Interferon-beta modulates protein synthesis in the central nervous system”. JOURNAL OF NEUROIMMUNOLOGY 213.1-2 (2009): 31-38.

Daten bereitgestellt von European Bioinformatics Institute (EBI)

4 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice.
Gross A, Benninger F, Madar R, Illouz T, Griffioen K, Steiner I, Offen D, Okun E., Epilepsia 58(4), 2017
PMID: 28166388

Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations.
Stadler K, Bierwirth C, Stoenica L, Battefeld A, Reetz O, Mix E, Schuchmann S, Velmans T, Rosenberger K, Bräuer AU, Lehnardt S, Nitsch R, Budt M, Wolff T, Kole MH, Strauss U., Cereb Cortex 24(1), 2014
PMID: 23042740

Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β.
Costello DA, Lynch MA., Hippocampus 23(8), 2013
PMID: 23554175

Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection.
Jurgens HA, Johnson RW., Brain Behav Immun 26(6), 2012
PMID: 22687335