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55 Publikationen

2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2915619
Romanova, Nadiya, and Noll, Thomas. 2017. “Engineered and Natural Promoters and Chromatin-Modifying Elements for Recombinant Protein Expression in CHO Cells”. Biotechnology Journal 13 (3): e1700232: 1700232.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2911396
Müller, B., Heinrich, C., Jabs, W., Kaspar-Schönefeld, S., Schmidt, Anica, Wehmeier, Nadine, Albaum, Stefan, Baessmann, C., Noll, Thomas, and Hoffrogge, Raimund. 2017. “Label-free protein quantification of sodium butyrate treated CHO cells by ESI-UHR-TOF-MS”. Journal of Biotechnology 257: 87-98.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2914045
Wippermann, Anna, and Noll, Thomas. 2017. “DNA methylation in CHO cells”. Journal of Biotechnology 258 (SI): 206-210.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906640
Coronel, Juliana, Klausing, Sandra, Heinrich, Christoph, Noll, Thomas, Figueredo-Cardero, Alvio, and Castilho, Leda R. 2016. “Valeric acid supplementation combined to mild hypothermia increases productivity in CHO cell cultivations”. Biochemical Engineering Journal 114: 101-109.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2907079
Wippermann, Anna, Rupp, Oliver, Brinkrolf, Karina, Hoffrogge, Raimund, and Noll, Thomas. 2016. “Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells”. Journal of Biotechnology 257: 150-161.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906641
Beatson, Richard, Tajadura-Ortega, Virginia, Achkova, Daniela, Picco, Gianfranco, Tsourouktsoglou, Theodora-Dorita, Klausing, Sandra, Hillier, Matthew, et al. 2016. “The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9”. Nature Immunology 17 (11): 1273-1281.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2718767
Wingens, Marc, Gätgens, Jochem, Schmidt, Anica, Albaum, Stefan, Büntemeyer, Heino, Noll, Thomas, and Hoffrogge, Raimund. 2015. “2D-DIGE screening of high-productive CHO cells under glucose limitation — Basic changes in the proteome equipment and hints for epigenetic effects”. Journal of Biotechnology 201: 86-97.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2718773
Wippermann, Anna, Rupp, Oliver, Brinkrolf, Karina, Hoffrogge, Raimund, and Noll, Thomas. 2015. “The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cells”. Journal of Biotechnology 199: 38-46.
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2015 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2902782
Knebel, C., Marx-Stoelting, P., Pfeil, R., Seeger, B., Steinberg, P., Mentz, Almut, Bednarz, Hanna, et al. 2015. “Multi-level omics analysis of combination effects of (tri-)azoles in a set of different cell lines”, Toxicology Letters, 238 (2): S355.
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2014 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2694187
Brinkrolf, Karina, Hoffrogge, Raimund, Hackl, Matthias, Tauch, Andreas, Baumann, Martina, Noll, Thomas, Goesmann, Alexander, Pühler, Alfred, and Borth, Nicole. 2014. “Functional -Omics for Cell Lines and Processes - The -Omics Technologies on the Example of CHO Cells”. In Animal Cell Biotechnology In Biologics Production, ed. Hansjörg Hauser and Roland Wagner. Berlin, Germany: Walter de Gruyter.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656819
Wippermann, Anna, Klausing, Sandra, Rupp, Oliver, Albaum, Stefan, Büntemeyer, Heino, Noll, Thomas, and Hoffrogge, Raimund. 2014. “Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells”. Applied Microbiology and Biotechnology 98 (2): 579-589.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2685988
Jakobi, Tobias, Brinkrolf, Karina, Tauch, Andreas, Noll, Thomas, Stoye, Jens, Pühler, Alfred, and Goesmann, Alexander. 2014. “Discovery of transcription start sites in the Chinese hamster genome by next-generation RNA sequencing”. Journal of Biotechnology 190: 64-75.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2676552
Becker, Jennifer, Timmermann, Christina, Rupp, Oliver, Albaum, Stefan, Brinkrolf, Karina, Goesmann, Alexander, Pühler, Alfred, Tauch, Andreas, and Noll, Thomas. 2014. “Transcriptome analyses of CHO cells with the next-generation microarray CHO41K: Development and validation by analysing the influence of the growth stimulating substance IGF-1 substitute LongR(3.)”. Journal of biotechnology 178: 23-31.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2701280
Noll, Thomas, Pühler, Alfred, Weisshaar, Bernd, and Wendisch, Volker F. 2014. “The Genomics Revolution and its Impact on Future Biotechnology”. Journal of Biotechnology 190: 1-1: 1.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656773
Rupp, Oliver, Becker, Jennifer, Brinkrolf, Karina, Timmermann, Christina, Borth, Nicole, Pühler, Alfred, Noll, Thomas, and Goesmann, Alexander. 2014. “Construction of a Public CHO Cell Line Transcript Database Using Versatile Bioinformatics Analysis Pipelines”. PLoS ONE 9 (1): e85568: e85568.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2679670
Rath, Alexander G., Rehberg, Markus, Janke, Robert, Genzel, Yvonne, Scholz, Sebastian, Noll, Thomas, Rose, Thomas, Sandig, Volker, and Reichl, Udo. 2014. “The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells”. Journal of Biotechnology 178: 43-53.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2615581
Brinkrolf, Karina, Rupp, Oliver, Laux, Holger, Kollin, Florian, Ernst, Wolfgang, Linke, Burkhard, Kofler, Rudolf, et al. 2013. “Chinese hamster genome sequenced from sorted chromosomes”. Nature Biotechnology 31 (8): 694-695.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2577265 OA
Klenke, Christin, Widera, Darius, Engelen, Thomas, Müller, Janine, Noll, Thomas, Niehaus, Karsten, Schmitz, M., Kaltschmidt, Barbara, and Kaltschmidt, Christian. 2013. “Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons”. PLoS ONE 8 (6): e65280: e65280.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2351519
Lenger, Janina, Schröder, Marius, Ennemann, Eva, Müller, Benjamin, Wong, C.-H., Noll, Thomas, Dierks, Thomas, Hanson, Sarah R., and Sewald, Norbert. 2012. “Evaluation of sulfatase-directed quinone methide traps for proteomics”. Bioorganic & Medical Chemistry 20 (2): 622-627.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2553404
Carrondo, Manuel J. T., Alves, Paula M., Carinhas, Nuno, Glassey, Jarka, Hesse, Friedemann, Merten, Otto-Wilhelm, Micheletti, Martina, et al. 2012. “How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?”. Biotechnology Journal 7 (12): 1522-1529.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2424989
Beckmann, Tim, Krämer, Oliver, Klausing, Sandra, Heinrich, Christoph, Thüte, Tobias, Büntemeyer, Heino, Hoffrogge, Raimund, and Noll, Thomas. 2012. “Effects of high passage cultivation on CHO cells: a global analysis”. Applied Microbiology Biotechnology 94 (3): 659-671.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2501364
Meleady, Paula, Hoffrogge, Raimund, Henry, Michael, Rupp, Oliver, Bort, Juan Hernandez, Clarke, Colin, Brinkrolf, Karina, et al. 2012. “Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics”. Biotechnology and Bioengineering 109 (6): 1386-1394.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2478526
Hackl, Matthias, Jadhav, Vaibhav, Jakobi, Tobias, Rupp, Oliver, Brinkrolf, Karina, Goesmann, Alexander, Pühler, Alfred, Noll, Thomas, Borth, Nicole, and Grillari, Johannes. 2012. “Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines”. Journal of Biotechnology 158 (3): 151-155.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2544205
Barradas, Oscar Platas, Jandt, Uwe, Da Minh Phan, Linh, Villanueva, Mario E., Schaletzky, Martin, Rath, Alexander, Freund, Susann, et al. 2012. “Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture”. Engineering In Life Sciences 12 (5): 518-528.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2453749
Klausing, Sandra, Krämer, Oliver, and Noll, Thomas. 2011. “Bioreactor cultivation of DP-12 cells under sodium butyrate treatment - comparative transcriptome analysis with CHO cDNA microarrays”. In BMC Proceedings, ed. Hauser Hansjörg, 5:P98. BMC Proceedings. BioMed Central: P98.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2453755
Beckmann, Tim, Thüte, Tobias, Heinrich, Christoph, Büntemeyer, Heino, and Noll, Thomas. 2011. “Proteomic and metabolomic characterization of DP-12 cell lines with different high passage histories”. In BMC Proceedings, 5:P92. BMC Proceedings. BioMed Central: P92.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2453760
Heinrich, Christoph, Timo, Wolf, Christina, Kropp, Northoff, Stefan, and Noll, Thomas. 2011. “Growth characterization of CHO DP-12 cell lines with different high passage histories”. In BMC Proceedings, ed. Hauser Hansjörg, 5:P29. BMC Proceedings. BioMed Central: P29.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375038
Beckmann, Tim, Thüte, Tobias, Heinrich, Christoph, Büntemeyer, Heino, and Noll, Thomas. 2011. “Proteomic and metabolomic characterization of CHO DP-12 cell lines with different high passage histories”, BMC Proceedings, 5 (Suppl 8).
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2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453752
Volmer, Martin, Gettmann, Julia, Scholz, Sebastian, Büntemeyer, Heino, and Noll, Thomas. 2011. “A method for metabolomic sampling of suspended animal cells using fast filtration”, BMC Proceedings, 5 (8): 95.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447654
Platas Barradas, Oscar, Jandt, Uwe, Da Minh Phan, Linh, Villanueva, Mario, Rath, Alexander, Reichl, Udo, Schräder, Eva Maria, et al. 2011. “Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture”, BMC Proceedings, 5 (8).
PUB | DOI | PubMed | Europe PMC
 
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375051
Heinrich, Christoph, Beckmann, Tim, Büntemeyer, Heino, and Noll, Thomas. 2011. “Utilization of multifrequency permittivity measurements in addition to biomass monitoring”, BMC Proceedings, 5 (Suppl 8).
PUB | DOI | PubMed | Europe PMC
 
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396576
Becker, Jennifer, Hackel, M, Jakobi, Tobias, Rupp, Oliver, Schneider, Jessica, Szczepanowski, Rafael, Bekel, Thomas, et al. 2011. “Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing”. Journal of Biotechnology 156 (3): 227-235.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375605
Klausing, Sandra, Krämer, Oliver, and Noll, Thomas. 2011. “Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment – comparative transcriptome analysis with CHO cDNA microarrays”, BMC Proceedings, 5 (Suppl 8).
PUB | DOI | PubMed | Europe PMC
 
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442843
Skerhutt, Eva Maria, Scholz, Sebastian, Niklas, Jens, Rath, Alexander, Platas Barradas, Oscar, Jandt, Uwe, Sandig, Volker, et al. 2011. “Characterisation of cultivation of the human cell line AGE1.HN.AAT”, BMC Proceedings, 5 (8).
PUB | DOI | PubMed | Europe PMC
 
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442810
Skerhutt, Eva Maria, Scholz, Sebastian, Sandig, Volker, Hoffrogge, Raimund, and Noll, Thomas. 2011. “Analysis of the mitochondrial subproteome of the human cell line AGE1.HN – a contribution to a systems biology approach”, BMC Proceedings, 5 (8).
PUB | DOI | PubMed | Europe PMC
 
2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453768
Becker, Jennifer, Timmermann, Christina, Jakobi, Tobias, Rupp, Oliver, Szczepanowski, Rafael, Hackl, Matthias, Goesmann, Alexander, et al. 2011. “Next-generation sequencing of the CHO cell transcriptome”, BMC Proceedings, 5 (Suppl. 8): P6.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447643
Scholz, Sebastian, Luebbecke, Miriam, Rath, Alexander, Schräder, Eva Maria, Rose, Thomas, Büntemeyer, Heino, Scheper, Thomas, Reichl, Udo, and Noll, Thomas. 2011. “Characterization of the human AGE1.HN cell line: a systems biology approach”, BMC Proceedings, 5 (8).
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2289895
Niklas, Jens, Skerhutt, Eva Maria, Sandig, Volker, Noll, Thomas, and Heinzle, Elmar. 2011. “Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis”. Bioprocess and Biosystems Engineering 34 (5): 533-545.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2094364
Volmer, Martin, Northoff, Stefan, Scholz, Sebastian, Thüte, Tobias, Büntemeyer, Heino, and Noll, Thomas. 2011. “Fast filtration for metabolome sampling of suspended animal cells”. Biotechnology Letters 33 (3): 495-502.
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396494
Nottorf, Tobias, Büntemeyer, Heino, Siwiora Brenke, Sonja, Lütkemeyer, Dirk, Loa, Alexander, Noll, Thomas, and Lehmann, Jürgen. 2010. “An integrated production process for human growth hormone”. In ESACT Proceedings, ed. Thomas Noll, 4:205-208. Springer.
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396499
Bäckström, Malin, Karlsson, Hasse, Gätgens, Jochem, Noll, Thomas, and Hansson, Gunnar C. 2010. “O-glycans on recombinant MUC1 produced in CHO K1 cells becomes less sialylated with increased productivity as determined by LC ESI MS”. In ESACT Proceedings, ed. Thomas Noll, 4:285-288. Springer.
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396502
Wiendahl, Christiane, Brandner, Jürgen J, Klein, Bianca, Küppers, Claudia, Luo, Bing, Ritchie, Steve, Mazurek, Sabine, et al. 2010. “Metabolome analysis in mammalian cells: Development and application of a sampling technique”. In ESACT Proceedings, ed. Thomas Noll, 4:413-420. Dordrecht: Springer.
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2010 | Herausgeber*in Sammelwerk | Veröffentlicht | PUB-ID: 2453825
Noll, Thomas, ed. 2010. Cells and Culture. Vol. 4. ESACT Proceedings. Springer.
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396497
Wingens, Marc, Gätgens, Jochem, Hoffrogge, Raimund, and Noll, Thomas. 2010. “Proteomic characterization of a glucose-limited CHO perfusion process-analysis of metabolic changes and increase in productivity”. In ESACT Proceedings, ed. Thomas Noll, 4:265-269. Springer.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396489
Krämer, Oliver, Klausing, Sandra, and Noll, Thomas. 2010. “Methods in mammalian cell line engineering: from random mutagenesis to sequence specific approaches”. Applied Microbiology and Biotechnology 88 (2): 425-436.
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2010 | Konferenzbeitrag | PUB-ID: 2396573
Northoff, Stefan, Büntemeyer, Heino, Sandig, Volker, Zietze, S, and Noll, Thomas. 2010. “Characterization of the novel human AGE1hn cell line for production of recombinant proteins”. In ESACT Proceedings, ed. Thomas Noll, 4:693-697. Spinger.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1929340
Burgemeister, Sebastian, Nattkemper, Tim Wilhelm, Noll, Thomas, Hoffrogge, Raimund, and Flaschel, Erwin. 2010. “CellViCAM-Cell viability classification for animal cell cultures using dark field micrographs”. JOURNAL OF BIOTECHNOLOGY 149 (4): 310-316.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1590674
Widera, Darius, Zander, Christin, Heidbreder, Meike, Kasperek, Yvonne, Noll, Thomas, Seitz, Oliver, Saldamli, Belma, et al. 2009. “Adult Palatum as a Novel Source of Neural Crest-Related Stem Cells”. STEM CELLS 27 (8): 1899-1910.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396483
Kubitzki, T, Minör, D, Mackfeld, U, and Noll, Thomas. 2009. “Application of immobilized bovine enterokinase in repetitive fusion protein cleavage for the production of MUC1”. Journal of Biotechnology 4 (11): 1610-1618.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395472
Magin, S, Körfer, N, Partenheimer, H, Lange, C, Zander, A, and Noll, Thomas. 2009. “Primary cells as feeder cells for clinical co-culture expansion of human hematopoietic stem cells from umbilical cord blood – a comparative study”. Stem Cell and Development 18 (1): 173-186.
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