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199 Publikationen

2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912550
Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform
Grünberger A, Probst C, Helfrich S, Nanda A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D (2015)
Cytometry / A 87(12): 1101–1115.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912555
Vizardous: interactive analysis of microbial populations with single cell resolution
Helfrich S, Azzouzi CE, Probst C, Seiffarth J, Grünberger A, Wiechert W, Kohlheyer D, Nöh K (2015)
Bioinformatics 31(23): 3875-3877.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912557
Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E (2015)
Lab on a chip 15(21): 4177-4186.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912562
Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar
Grünberger A (2015)
Biospektrum 21(3): 353-353.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912567
Single-cell bioreactors: Improving the understanding of microbial metabolism
Grünberger A (2015)
Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany.
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2015 | Dissertation | Veröffentlicht | PUB-ID: 2912574
Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors
Grünberger A (2015) Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies; 114.
Jülich: RWTH Aachen.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912804
Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants
Krämer C, Helfrich S, Singh A, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2015)
Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912549
Metabolite biosensors for single cell Analysis and the Evolution of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2015)
Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912551
Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging
Probst C, Grünberger A, Krämer C, Sachs CC, Wiechert W, Baumgart M, Kohlheyer D (2015)
Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912556
Lichtgesteuerte Genexpression auf Einzelzellebene
Binder D, Probst C, Bier C, Loeschcke A, Grünberger A (2015)
Biospektrum 21(6): 612-615.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912563
High-throughput, long-term growth characterization of C. glutamicum on single cell level using the Mother Machine
Sachs CC, Helfrich S, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2015)
Presented at the 3rd International Conference of the Cluster of Excellence Tailor-Made Fuels from Biomass, Aachen, Germany.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912568
Technical bias of microcultivation environments on single cell physiology
Dusny C, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Schmid A (2015)
Lab on a chip 15(8): 1822-1834.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912763
Microfluidic Single-Cell Cultivation: The key for next generation bioprocess development?
Grünberger A (2015)
Presented at the Colloquium Biotechnology, Technical Faculty - Bielefeld University, Bielefeld.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912542
Optical control of gene expression in bacteria on the single-cell level by caged compounds
Probst C, Grünberger A, Binder D, Steffen I, Wiechert W, Kohlheyer D (2015)
Presented at the Synthetic Biology: Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912559
High-throughput long-term growth characterization of C. glutamicum on single cell using the Mother Machine
Sachs CC, Helfrich S, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2015)
Presented at the Colloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912566
Single-Cell Bioreactors: Cutting Edge Cultivation Devices for the Ultimate Scale-Down of Bioprocesses
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2015)
Presented at the DECHEMA-Himmelfahrtstagung "Scale-up and scale-down of bioprocesses", Hamburg-Bergedorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912589
Microfluids as platform for the spatiotemporal analysis of bacterial populations at single-cell level
Helfrich S, Krämer C, Grünberger A, Azzouzi CE, Pfeifer E, Frunzke J, Wiechert W, Kohlheyer D, Nöh K (2014)
Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912591
Microfluidic Single-Cell Cultivation: Opportunity for Industrial Bioprocess Development
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Presented at the EMBL Conference – Microfluidics 2014, Heidelberg, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912596
Single-cell cultivation in picoliter scale: Opportunity for bioprocess development
Grünberger A, Probst C, Unthan S, Mustafi N, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Presented at the 3rd BioProScale Symposium, Berlin, Germany.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912616
Beyond growth rate 0.6. What drives Corynebacterium glutamicum to higher growth rates in defined medium
Unthan S, Grünberger A, van Ooyen J, Gätgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S (2014)
Biotechnology and bioengineering 111(2): 359–371.
PUB | DOI | WoS | PubMed | Europe PMC
 
2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912806
Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jäger K-E, Drepper T (2014)
Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912730
Analysis of SOS-Induced Spontaneous Prophage Induction in Corynebacterium glutamicum at the Single-Cell Level
Nanda AM, Heyer A, Kramer C, Grünberger A, Kohlheyer D, Frunzke J (2014)
Journal of Bacteriology 196(1): 180-188.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912766
Picoliter Bioreactors. Learning from Single Cells about Large Scale Processes
Grünberger A (2014)
Presented at the iGEM Meetup, Aachen, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912805
Microfluidic Single-Cell Analysis – Potential for Microalgae Research?
Kohlheyer D, Grünberger A, Weber S, Nedbal L, Wiechert W (2014)
Presented at the BioSC Workshop | Exploration "Perspectives of Algal Technologies", Jülich, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912808
Metabolite biosensors for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912583
Picoliter Bioreactors. Learning from Single Cells about Large-Scale Bioprocesses
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2014)
Presented at the 24th Annual conference of the German Society for Cytometry, Dresden, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912586
Microbial Populations on the Microfluidic Analyst's Couch: Approaching Cellular Heterogeneity
Helfrich S, Azzouzi CE, Krämer C, Pfeifer E, Grünberger A, Mustafi N, Wiechert W, Frunzke J, Kohlheyer D, Nöh K (2014)
Presented at the BioImage Informatics 2014, Leuven, Belgium.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912588
Investigating single-cell growth of microbial cell factories: is counting cells enough?
Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K (2014)
Presented at the 2nd International Workshop on Image-based Systems Biology, Jena (Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912590
Transcription factor-based biosensor for microbial strain development
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912593
Systematic screening of single-cell growth and production in a picoliter cultivation platform
Grünberger A, Unthan S, Mahr R, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Chemie Ingenieur Technik 86(9): 1408.
PUB | DOI
 
2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912595
Single-cell Bioreactors boost Bioprocess Development: New Insights into Cellular Metabolism
Kohlheyer D, Grünberger A, Probst C, Helfrich S, Frunzke J, Eggeling L, Nöh K, Noack S, Wiechert W (2014)
Presented at the Metabolic Engineering X, Vancouver, Canada.
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2014 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912601
Simple microfluidics for complex organisms: A microfluidic chip System for growth and Morphogenesis studies of filamentous fungi
Grünberger A, Schmitz K, Probst C, Noack S, Wiechert W, Kohlheyer D (2014)
In: 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). Red Hook, NY: Curran.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912569
Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger K-E, Drepper T (2014)
Presented at the VAAM Jahrestagung, Dresden, Germany.
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2014 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912571
Microfluidic Single-Cell Analysis Platform for Biotechnological Process Development
Grünberger A, Probst C, Helfrich S, Frunzke J, Noack S, Nöh K, Wiechert W, Kohlheyer D (2014)
In: MicroTAS 2014. San Diego, California: CBM Society: 3 p.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912576
From extracellular Environment to functional phenotype. Quantitative comparison of single cell physiology in static and steady environments
Dusny C, Grünberger A, Wiechert W, Kohlheyer D, Schmid A (2014)
Presented at the 3rd BioProScale Symposium "Inhomogeneities in large-scale bioprocesses. System biology and process dynamics", Berlin, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912582
Microfluidic Single-Cell Cultivation Systems: Versatile Tools for Microbiology
Grünberger A, Probst C, Nanda A, Frunzke J, Wiechert W, Kohlheyer D (2014)
Presented at the 4th Annual Conference of the Association for General and Applied Microbiology, Dresden, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912587
Metabolite biosensors for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the Gemeinsame Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie und der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Dresden, Germany.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912594
Light-responsive control of bacterial gene Expression: precise triggering of the lac promoter activity using photocaged IPTG
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger K-E, Drepper T (2014)
Integrative biology 6(8): 755-765.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912823
Application of a genetically-encoded metabolite sensor for single cell analysis and development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the Metabolic engineering X, Vancouver, Canada.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912575
Microfluidics as platform for the spatiotemporal analysis of bacterial populations at single-cell level
Krämer C, Helfrich S, Azzouzi CE, Grünberger A, Pfeifer E, Frunzke J, Wiechert W, Nöh K, Kohlheyer D (2014)
Presented at the International Meeting, Phenotypic heterogeneity and sociobiology of bacterial populations, Irsee, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912814
Introduction into Microfluidic Single-Cell Analysis
Grünberger A, Probst C (2014)
Presented at the Biology feat, Engineering – SYNBIO – Single Cell Analysis in Microfluidic Devices (Workshop), Jülich, Germany.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912605
Taking Control over Control: Use of Product Sensing in Single Cells to Remove Flux Control at Key Enzymes in Biosynthesis Pathways
Schendzielorz G, Dippong M, Grünberger A, Kohlheyer D, Yoshida A, Binder S, Nishiyama C, Nishiyama M, Bott M, Eggeling L (2014)
ACS Synthetic Biology 3(1): 21–29.
PUB | DOI | WoS | PubMed | Europe PMC
 
2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912580
Quantitative Physiology of Single Cells for Linking Phenotype and Environment
Dusny C, Grünberger A, Rosenthal K, Wiechert W, Schmid A (2014)
Presented at the 24th Annual Conference of the German Society for Flow Cytometry, Dresden, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912585
Robust Automated Image Analysis of Mother Machine Microfluidic Growth Devices
Sachs CC, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2014)
Presented at the BioImage Informatics 2014, Leuven, Belgium.
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2014 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912592
Optimizing growth performance of Corynebacterium glutamicum at the single-cell level
Weber S, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2014)
Chemie Ingenieur Technik 88(9): 1414.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912597
Single-cell microfluidics: opportunity for bioprocess development
Grünberger A, Wiechert W, Kohlheyer D (2014)
Current opinion in biotechnology 29: 15-23.
PUB | DOI | WoS | PubMed | Europe PMC
 
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912573
Application of a Genetically Encoded Biosensor for Live Cell Imaging of L-Valine Production in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains
Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J (2014)
PLoS one 9(1): e85731.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912604
Application of a genetically encoded biosensor for single cell analysis and strain development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2013)
Presented at the New concepts and approaches in microbiology, Heidelberg, Germany.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912609
Single-cell Dynamics of the SOS Response in Corynebacterium glutamicum
Nanda A, Heyer A, Grünberger A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2013)
Presented at the Bacterial Networks, Pultusk, Poland.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912611
Polydimethylsiloxane (PDMS) Sub-Micron Traps for Single-Cell Analysis of Bacteria
Probst C, Grünberger A, Wiechert W, Kohlheyer D (2013)
Micromachines 4(4): 357-369.
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