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199 Publikationen

2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912550
Grünberger, Alexander, Probst, Christopher, Helfrich, Stefan, Nanda, Arun, Stute, Birgit, Wiechert, Wolfgang, von Lieres, Eric, Nöh, Katharina, Frunzke, Julia, and Kohlheyer, Dietrich. 2015. “Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform”. Cytometry / A 87 (12): 1101–1115.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912555
Helfrich, Stefan, Azzouzi, Charaf E., Probst, Christopher, Seiffarth, Johannes, Grünberger, Alexander, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. 2015. “Vizardous: interactive analysis of microbial populations with single cell resolution”. Bioinformatics 31 (23): 3875-3877.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912557
Westerwalbesloh, Christoph, Grünberger, Alexander, Stute, Birgit, Weber, Sophie, Wiechert, Wolfgang, Kohlheyer, Dietrich, and von Lieres, Eric. 2015. “Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level”. Lab on a chip 15 (21): 4177-4186.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912562
Grünberger, Alexander. 2015. “Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar”. Biospektrum 21 (3): 353-353.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912567
Grünberger, Alexander. 2015. “Single-cell bioreactors: Improving the understanding of microbial metabolism”. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany .
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2015 | Dissertation | Veröffentlicht | PUB-ID: 2912574
Grünberger, Alexander. 2015. Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors. Vol. 114. Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies. Jülich: RWTH Aachen.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912549
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. 2015. “Metabolite biosensors for single cell Analysis and the Evolution of production strains”. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912551
Probst, Christopher, Grünberger, Alexander, Krämer, Christina, Sachs, Christian Carsten, Wiechert, Wolfgang, Baumgart, Meike, and Kohlheyer, Dietrich. 2015. “Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging”. Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany .
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912556
Binder, Dennis, Probst, Christopher, Bier, Claus, Loeschcke, Anita, and Grünberger, Alexander. 2015. “Lichtgesteuerte Genexpression auf Einzelzellebene”. Biospektrum 21 (6): 612-615.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912563
Sachs, Christian Carsten, Helfrich, Stefan, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. 2015. “High-throughput, long-term growth characterization of C. glutamicum on single cell level using the Mother Machine”. Presented at the 3rd International Conference of the Cluster of Excellence Tailor-Made Fuels from Biomass, Aachen, Germany .
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912568
Dusny, Christian, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Schmid, Andreas. 2015. “Technical bias of microcultivation environments on single cell physiology”. Lab on a chip 15 (8): 1822-1834.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912804
Krämer, Christina, Helfrich, Stefan, Singh, Abhijeet, Grünberger, Alexander, Wiechert, Wolfgang, Nöh, Katharina, and Kohlheyer, Dietrich. 2015. “Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants”. Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912763
Grünberger, Alexander. 2015. “Microfluidic Single-Cell Cultivation: The key for next generation bioprocess development?”. Presented at the Colloquium Biotechnology, Technical Faculty - Bielefeld University, Bielefeld .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912542
Probst, Christopher, Grünberger, Alexander, Binder, Dennis, Steffen, Iska, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2015. “Optical control of gene expression in bacteria on the single-cell level by caged compounds”. Presented at the Synthetic Biology: Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912559
Sachs, Christian Carsten, Helfrich, Stefan, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. 2015. “High-throughput long-term growth characterization of C. glutamicum on single cell using the Mother Machine”. Presented at the Colloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912566
Grünberger, Alexander, Probst, C., Wiechert, W., and Kohlheyer, D. 2015. “Single-Cell Bioreactors: Cutting Edge Cultivation Devices for the Ultimate Scale-Down of Bioprocesses”. Presented at the DECHEMA-Himmelfahrtstagung "Scale-up and scale-down of bioprocesses", Hamburg-Bergedorf, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912589
Helfrich, Stefan, Krämer, Christina, Grünberger, Alexander, Azzouzi, Charaf Eddine, Pfeifer, Eugen, Frunzke, Julia, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. 2014. “Microfluids as platform for the spatiotemporal analysis of bacterial populations at single-cell level”. Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912591
Grünberger, Alexander, Probst, Christopher, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2014. “Microfluidic Single-Cell Cultivation: Opportunity for Industrial Bioprocess Development”. Presented at the EMBL Conference – Microfluidics 2014, Heidelberg, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912596
Grünberger, Alexander, Probst, Christopher, Unthan, Simon, Mustafi, Nurije, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2014. “Single-cell cultivation in picoliter scale: Opportunity for bioprocess development”. Presented at the 3rd BioProScale Symposium, Berlin, Germany .
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912616
Unthan, Simon, Grünberger, Alexander, van Ooyen, Jan, Gätgens, Jochem, Heinrich, Johanna, Paczia, Nicole, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Noack, Stephan. 2014. “Beyond growth rate 0.6. What drives Corynebacterium glutamicum to higher growth rates in defined medium”. Biotechnology and bioengineering 111 (2): 359–371.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912806
Binder, Dennis, Grünberger, Alexander, Loeschcke, Anita, Probst, Christopher, Bier, Claus, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jäger, Karl-Erich, and Drepper, Thomas. 2014. “Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers”. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany .
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912730
Nanda, Arun M., Heyer, Antonia, Kramer, Christina, Grünberger, Alexander, Kohlheyer, Dietrich, and Frunzke, Julia. 2014. “Analysis of SOS-Induced Spontaneous Prophage Induction in Corynebacterium glutamicum at the Single-Cell Level”. Journal of Bacteriology 196 (1): 180-188.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912766
Grünberger, Alexander. 2014. “Picoliter Bioreactors. Learning from Single Cells about Large Scale Processes”. Presented at the iGEM Meetup, Aachen, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912805
Kohlheyer, Dietrich, Grünberger, Alexander, Weber, S., Nedbal, Ladislav, and Wiechert, Wolfgang. 2014. “Microfluidic Single-Cell Analysis – Potential for Microalgae Research?”. Presented at the BioSC Workshop | Exploration "Perspectives of Algal Technologies", Jülich, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912808
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. 2014. “Metabolite biosensors for single cell analysis and the development of production strains”. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912569
Binder, Dennis, Grünberger, Alexander, Loeschcke, Anita, Probst, Christopher, Bier, Claus, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jaeger, Karl-Erich, and Drepper, Thomas. 2014. “Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers”. Presented at the VAAM Jahrestagung, Dresden, Germany .
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2014 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912571
Grünberger, Alexander, Probst, Christopher, Helfrich, Stefan, Frunzke, Julia, Noack, Stephan, Nöh, Katharina, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2014. “Microfluidic Single-Cell Analysis Platform for Biotechnological Process Development”. In MicroTAS 2014, 3 p. San Diego, California: CBM Society.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912576
Dusny, Christian, Grünberger, Alexander, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Schmid, Andreas. 2014. “From extracellular Environment to functional phenotype. Quantitative comparison of single cell physiology in static and steady environments”. Presented at the 3rd BioProScale Symposium "Inhomogeneities in large-scale bioprocesses. System biology and process dynamics", Berlin, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912583
Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2014. “Picoliter Bioreactors. Learning from Single Cells about Large-Scale Bioprocesses”. Presented at the 24th Annual conference of the German Society for Cytometry, Dresden, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912586
Helfrich, Stefan, Azzouzi, Charaf Eddine, Krämer, Christina, Pfeifer, Eugen, Grünberger, Alexander, Mustafi, Nurije, Wiechert, Wolfgang, Frunzke, Julia, Kohlheyer, Dietrich, and Nöh, Katharina. 2014. “Microbial Populations on the Microfluidic Analyst's Couch: Approaching Cellular Heterogeneity”. Presented at the BioImage Informatics 2014, Leuven, Belgium .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912588
Helfrich, Stefan, Grünberger, Alexander, Kohlheyer, Dietrich, Wiechert, Wolfgang, and Nöh, Katharina. 2014. “Investigating single-cell growth of microbial cell factories: is counting cells enough?”. Presented at the 2nd International Workshop on Image-based Systems Biology, Jena (Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912590
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. 2014. “Transcription factor-based biosensor for microbial strain development”. Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912593
Grünberger, Alexander, Unthan, Simon, Mahr, Regina, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2014. “Systematic screening of single-cell growth and production in a picoliter cultivation platform”, Chemie Ingenieur Technik, 86 (9): 1408.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912595
Kohlheyer, Dietrich, Grünberger, Alexander, Probst, Christopher, Helfrich, Stefan, Frunzke, Julia, Eggeling, Lothar, Nöh, Katharina, Noack, Stephan, and Wiechert, Wolfgang. 2014. “Single-cell Bioreactors boost Bioprocess Development: New Insights into Cellular Metabolism”. Presented at the Metabolic Engineering X, Vancouver, Canada .
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2014 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912601
Grünberger, Alexander, Schmitz, Katja, Probst, Christopher, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2014. “Simple microfluidics for complex organisms: A microfluidic chip System for growth and Morphogenesis studies of filamentous fungi”. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). Red Hook, NY: Curran.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912575
Krämer, Christina, Helfrich, Stefan, Azzouzi, Charaf Eddine, Grünberger, Alexander, Pfeifer, Eugen, Frunzke, Julia, Wiechert, Wolfgang, Nöh, Katharina, and Kohlheyer, Dietrich. 2014. “Microfluidics as platform for the spatiotemporal analysis of bacterial populations at single-cell level”. Presented at the International Meeting, Phenotypic heterogeneity and sociobiology of bacterial populations, Irsee, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912582
Grünberger, Alexander, Probst, Christopher, Nanda, Arun, Frunzke, Julia, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2014. “Microfluidic Single-Cell Cultivation Systems: Versatile Tools for Microbiology”. Presented at the 4th Annual Conference of the Association for General and Applied Microbiology, Dresden, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912587
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. 2014. “Metabolite biosensors for single cell analysis and the development of production strains”. Presented at the Gemeinsame Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie und der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Dresden, Germany .
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912594
Binder, Dennis, Grünberger, Alexander, Loeschcke, Anita, Probst, Christopher, Bier, Claus, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jaeger, Karl-Erich, and Drepper, Thomas. 2014. “Light-responsive control of bacterial gene Expression: precise triggering of the lac promoter activity using photocaged IPTG”. Integrative biology 6 (8): 755-765.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912823
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. 2014. “Application of a genetically-encoded metabolite sensor for single cell analysis and development of production strains”. Presented at the Metabolic engineering X, Vancouver, Canada .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912814
Grünberger, Alexander, and Probst, Christopher. 2014. “Introduction into Microfluidic Single-Cell Analysis”. Presented at the Biology feat, Engineering – SYNBIO – Single Cell Analysis in Microfluidic Devices (Workshop), Jülich, Germany .
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912605
Schendzielorz, Georg, Dippong, Martin, Grünberger, Alexander, Kohlheyer, Dietrich, Yoshida, Ayako, Binder, Stephan, Nishiyama, Chiharu, Nishiyama, Makoto, Bott, Michael, and Eggeling, Lothar. 2014. “Taking Control over Control: Use of Product Sensing in Single Cells to Remove Flux Control at Key Enzymes in Biosynthesis Pathways”. ACS Synthetic Biology 3 (1): 21–29.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912573
Mustafi, Nurije, Grünberger, Alexander, Mahr, Regina, Helfrich, Stefan, Nöh, Katharina, Blombach, Bastian, Kohlheyer, Dietrich, and Frunzke, Julia. 2014. “Application of a Genetically Encoded Biosensor for Live Cell Imaging of L-Valine Production in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains”. PLoS one 9 (1): e85731.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912580
Dusny, Christian, Grünberger, Alexander, Rosenthal, Katrin, Wiechert, Wolfgang, and Schmid, Andreas. 2014. “Quantitative Physiology of Single Cells for Linking Phenotype and Environment”. Presented at the 24th Annual Conference of the German Society for Flow Cytometry, Dresden, Germany .
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912585
Sachs, Christian Carsten, Grünberger, Alexander, Wiechert, Wolfgang, Nöh, Katharina, and Kohlheyer, Dietrich. 2014. “Robust Automated Image Analysis of Mother Machine Microfluidic Growth Devices”. Presented at the BioImage Informatics 2014, Leuven, Belgium .
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2014 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912592
Weber, Sophie, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2014. “Optimizing growth performance of Corynebacterium glutamicum at the single-cell level”, Chemie Ingenieur Technik, 88 (9): 1414.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912597
Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2014. “Single-cell microfluidics: opportunity for bioprocess development”. Current opinion in biotechnology 29: 15-23.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912604
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. 2013. “Application of a genetically encoded biosensor for single cell analysis and strain development of production strains”. Presented at the New concepts and approaches in microbiology, Heidelberg, Germany .
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912609
Nanda, Arun, Heyer, Antonia, Grünberger, Alexander, Helfrich, Stefan, Kohlheyer, Dietrich, Nöh, Katharina, and Frunzke, Julia. 2013. “Single-cell Dynamics of the SOS Response in Corynebacterium glutamicum”. Presented at the Bacterial Networks, Pultusk, Poland .
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912611
Probst, Christopher, Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2013. “Polydimethylsiloxane (PDMS) Sub-Micron Traps for Single-Cell Analysis of Bacteria”. Micromachines 4 (4): 357-369.
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