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199 Publikationen

2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912532
Westerwalbesloh, C., Grünberger, A., Stute, B., Weber, S., Kohlheyer, D., and von Lieres, E. (2016).“Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells”. Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912537
Grünberger, A., Wiechert, W., and Kohlheyer, D. (2016).“Bioprocesses under magnification. Learning from single cells about large-scale processes”. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912544
Binder, D., Bier, C., Grünberger, A., Drobietz, D., Hage-Hülsmann, J., rey, G., Büchs, J., Kohlheyer, D., Loeschcke, A., Wiechert, W., et al. (2016). Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression. ChemBioChem 17, 296-299.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912739
Li, S., Jendresen, C. B., Grünberger, A., Ronda, C., Jensen, S. I., Noack, S., and Nielsen, A. T. (2016). Enhanced protein and biochemical production using CRISPRi-based growth switches. Metabolic Engineering 38, 274-284.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912760
Grünberger, A. (2016).“Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level”. Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912772
Grünberger, A., Sachs, C., Kohlheyer, D., Wiechert, W., and Nöh, K. (2016).“Spatio-temporal analysis of bacterial populations at single-cell level”. Presented at the IBG Modelling Workshop, Jülich, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912511
Bier, C., Binder, D., Grünberger, A., Drobietz, D., Kohlheyer, D., Löschcke, A., Jaeger, K. - E., Drepper, T., and Pietruszka, J. (2016).“Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications”. Presented at the 18th International Conference on Photochemistry, Paris, France.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912523
Brehl, C., Grünberger, A., Probst, C., Pfaff, C., Wiechert, W., Behrendt, D., and Kohlheyer, D. (2016).“Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments”. Presented at the ProcessNet 2016, Aachen, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912530
Kaganovitch, E., Probst, C., Westerwalbesloh, C., Grünberger, A., Wiechert, W., and Kohlheyer, D. (2016).“Single-cell analysis of E. coli in microfluidic batch reactors”. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912535
Grünberger, A., Steffens, I., Binder, D., Drepper, T., Wiechert, W., and Kohlheyer, D. (2016).“Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression”. Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904866
Binder, D., Frohwitter, J., Mahr, R., Bier, C., Grünberger, A., Loeschcke, A., Peters-Wendisch, P., Kohlheyer, D., Pietruszka, J., Frunzke, J., et al. (2016). Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum. Appl Environ Microbiol 82, 6141-6149.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912554 OA
Krämer, C. E. M., Singh, A., Helfrich, S., Grünberger, A., Wiechert, W., Nöh, K., and Kohlheyer, D. (2015). Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester. PLoS one 10:e0141768.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912541
Binder, D., Bier, C., Grünberger, A., Loeschcke, A., Kohlheyer, D., Pietruszka, J., Jaeger, K. - E., and Drepper, T. (2015).“Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications”. Presented at the ESP Photobiology conference, Aveiro, Portugal.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912546
Grünberger, A., Wiechert, W., and Kohlheyer, D. (2015).“Single-cell microfluidics: A key technology to understand life at environmental defined conditions”. Presented at the Kick-off Konferenz: Leben? - Eine neue Förderinitiative stellt sich vor, Hannover, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912560
Zunic, E., Schechtel, A., Probst, C., Grünberger, A., Freier, C., Seibold, G., Wiechert, W., and Kohlheyer, D. (2015).“Dynamic environmental control in microfluidic devices for single-cell Analysis of biological production processes”. Presented at the Kolloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912565
Grünberger, A., Probst, C., Frunzke, J., Noack, S., Wiechert, W., and Kohlheyer, D. (2015).“Single-cell microfluidics meets applied biotechnology. From expectation to application”. Presented at the Conference "Cell Factories and Biosustainability - Technologies for Cell Factory Construction", Hillerod, Denmark.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912584
Probst, C., Grünberger, A., Braun, N., Helfrich, S., Nöh, K., Wiechert, W., and Kohlheyer, D. (2015). Rapid inoculation of single bacteria into parallel picoliter fermentation chambers. Analytical methods 7, 91-98.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912773
Grünberger, A., Probst, C., Frunzke, J., Noack, S., Wiechert, W., and Kohlheyer, D. (2015).“Single-cell microfluidics meets applied biotechnology. From expectation to application”. Presented at the Jahreskongress Biotechnologie 2020+, Berlin, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912545
Loeschcke, A., Thies, S., Hage-Hülsmann, J., Grünberger, A., Binder, D., Domröse, A., Klein, A., Kohlheyer, D., Pietruszka, J., Jaeger, K. - E., et al. (2015).“Heterologous production of antibacterial secondary metabolites from Serratia marcescens in Pseudomonas putida”. Presented at the 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912548
Bier, C., Binder, D., Grünberger, A., Drobietz, D., Hage-Hülsmann, J., Kohlheyer, D., Loeschke, A., Jaeger, K. - E., Drepper, T., and Pietruszka, J. (2015).“Caged Compounds for Biotechnological and Synthetic Biological Applications”. Presented at the European Society for Photobiology 2015 Congress, Aveiro, Portugal.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912550
Grünberger, A., Probst, C., Helfrich, S., Nanda, A., Stute, B., Wiechert, W., von Lieres, E., Nöh, K., Frunzke, J., and Kohlheyer, D. (2015). Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform. Cytometry / A 87, 1101–1115.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912555
Helfrich, S., Azzouzi, C. E., Probst, C., Seiffarth, J., Grünberger, A., Wiechert, W., Kohlheyer, D., and Nöh, K. (2015). Vizardous: interactive analysis of microbial populations with single cell resolution. Bioinformatics 31, 3875-3877.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912557 OA
Westerwalbesloh, C., Grünberger, A., Stute, B., Weber, S., Wiechert, W., Kohlheyer, D., and von Lieres, E. (2015). Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level. Lab on a chip 15, 4177-4186.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912562
Grünberger, A. (2015). Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar. Biospektrum 21, 353-353.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912567
Grünberger, A. (2015).“Single-cell bioreactors: Improving the understanding of microbial metabolism”. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany.
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2015 | Dissertation | Veröffentlicht | PUB-ID: 2912574 OA
Grünberger, A. (2015). Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors. Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies, 114, Jülich: RWTH Aachen.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912549
Mahr, R., Mustafi, N., Grünberger, A., Helfrich, S., Nöh, K., Kohlheyer, D., and Frunzke, J. (2015).“Metabolite biosensors for single cell Analysis and the Evolution of production strains”. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912551
Probst, C., Grünberger, A., Krämer, C., Sachs, C. C., Wiechert, W., Baumgart, M., and Kohlheyer, D. (2015).“Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging”. Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912556
Binder, D., Probst, C., Bier, C., Loeschcke, A., and Grünberger, A. (2015). Lichtgesteuerte Genexpression auf Einzelzellebene. Biospektrum 21, 612-615.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912563
Sachs, C. C., Helfrich, S., Grünberger, A., Probst, C., Wiechert, W., Kohlheyer, D., and Nöh, K. (2015).“High-throughput, long-term growth characterization of C. glutamicum on single cell level using the Mother Machine”. Presented at the 3rd International Conference of the Cluster of Excellence Tailor-Made Fuels from Biomass, Aachen, Germany.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912568
Dusny, C., Grünberger, A., Probst, C., Wiechert, W., Kohlheyer, D., and Schmid, A. (2015). Technical bias of microcultivation environments on single cell physiology. Lab on a chip 15, 1822-1834.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912804
Krämer, C., Helfrich, S., Singh, A., Grünberger, A., Wiechert, W., Nöh, K., and Kohlheyer, D. (2015).“Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants”. Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912763
Grünberger, A. (2015).“Microfluidic Single-Cell Cultivation: The key for next generation bioprocess development?”. Presented at the Colloquium Biotechnology, Technical Faculty - Bielefeld University, Bielefeld.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912542
Probst, C., Grünberger, A., Binder, D., Steffen, I., Wiechert, W., and Kohlheyer, D. (2015).“Optical control of gene expression in bacteria on the single-cell level by caged compounds”. Presented at the Synthetic Biology: Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912559
Sachs, C. C., Helfrich, S., Grünberger, A., Probst, C., Wiechert, W., Kohlheyer, D., and Nöh, K. (2015).“High-throughput long-term growth characterization of C. glutamicum on single cell using the Mother Machine”. Presented at the Colloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912566
Grünberger, A., Probst, C., Wiechert, W., and Kohlheyer, D. (2015).“Single-Cell Bioreactors: Cutting Edge Cultivation Devices for the Ultimate Scale-Down of Bioprocesses”. Presented at the DECHEMA-Himmelfahrtstagung "Scale-up and scale-down of bioprocesses", Hamburg-Bergedorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912589
Helfrich, S., Krämer, C., Grünberger, A., Azzouzi, C. E., Pfeifer, E., Frunzke, J., Wiechert, W., Kohlheyer, D., and Nöh, K. (2014).“Microfluids as platform for the spatiotemporal analysis of bacterial populations at single-cell level”. Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912591
Grünberger, A., Probst, C., Frunzke, J., Noack, S., Wiechert, W., and Kohlheyer, D. (2014).“Microfluidic Single-Cell Cultivation: Opportunity for Industrial Bioprocess Development”. Presented at the EMBL Conference – Microfluidics 2014, Heidelberg, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912596
Grünberger, A., Probst, C., Unthan, S., Mustafi, N., Frunzke, J., Noack, S., Wiechert, W., and Kohlheyer, D. (2014).“Single-cell cultivation in picoliter scale: Opportunity for bioprocess development”. Presented at the 3rd BioProScale Symposium, Berlin, Germany.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912616
Unthan, S., Grünberger, A., van Ooyen, J., Gätgens, J., Heinrich, J., Paczia, N., Wiechert, W., Kohlheyer, D., and Noack, S. (2014). Beyond growth rate 0.6. What drives Corynebacterium glutamicum to higher growth rates in defined medium. Biotechnology and bioengineering 111, 359–371.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912806
Binder, D., Grünberger, A., Loeschcke, A., Probst, C., Bier, C., Pietruszka, J., Wiechert, W., Kohlheyer, D., Jäger, K. - E., and Drepper, T. (2014).“Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers”. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912730 OA
Nanda, A. M., Heyer, A., Kramer, C., Grünberger, A., Kohlheyer, D., and Frunzke, J. (2014). Analysis of SOS-Induced Spontaneous Prophage Induction in Corynebacterium glutamicum at the Single-Cell Level. Journal of Bacteriology 196, 180-188.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912766
Grünberger, A. (2014).“Picoliter Bioreactors. Learning from Single Cells about Large Scale Processes”. Presented at the iGEM Meetup, Aachen, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912805
Kohlheyer, D., Grünberger, A., Weber, S., Nedbal, L., and Wiechert, W. (2014).“Microfluidic Single-Cell Analysis – Potential for Microalgae Research?”. Presented at the BioSC Workshop | Exploration "Perspectives of Algal Technologies", Jülich, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912808
Mahr, R., Mustafi, N., Grünberger, A., Helfrich, S., Nöh, K., Kohlheyer, D., and Frunzke, J. (2014).“Metabolite biosensors for single cell analysis and the development of production strains”. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912569
Binder, D., Grünberger, A., Loeschcke, A., Probst, C., Bier, C., Pietruszka, J., Wiechert, W., Kohlheyer, D., Jaeger, K. - E., and Drepper, T. (2014).“Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers”. Presented at the VAAM Jahrestagung, Dresden, Germany.
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2014 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912571
Grünberger, A., Probst, C., Helfrich, S., Frunzke, J., Noack, S., Nöh, K., Wiechert, W., and Kohlheyer, D. (2014). “Microfluidic Single-Cell Analysis Platform for Biotechnological Process Development” in MicroTAS 2014 (San Diego, California: CBM Society), 3 p.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912576
Dusny, C., Grünberger, A., Wiechert, W., Kohlheyer, D., and Schmid, A. (2014).“From extracellular Environment to functional phenotype. Quantitative comparison of single cell physiology in static and steady environments”. Presented at the 3rd BioProScale Symposium "Inhomogeneities in large-scale bioprocesses. System biology and process dynamics", Berlin, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912583
Grünberger, A., Probst, C., Wiechert, W., and Kohlheyer, D. (2014).“Picoliter Bioreactors. Learning from Single Cells about Large-Scale Bioprocesses”. Presented at the 24th Annual conference of the German Society for Cytometry, Dresden, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912586
Helfrich, S., Azzouzi, C. E., Krämer, C., Pfeifer, E., Grünberger, A., Mustafi, N., Wiechert, W., Frunzke, J., Kohlheyer, D., and Nöh, K. (2014).“Microbial Populations on the Microfluidic Analyst's Couch: Approaching Cellular Heterogeneity”. Presented at the BioImage Informatics 2014, Leuven, Belgium.
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