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200 Publikationen

2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912512
Bier C, Binder D, Grünberger A, Drobietz D, Hage-Hülsmann J, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Sugar Based Caged Compounds for Biotechnological Synthetic Biological Applications.
Presented at the 26th IUPAC Symposium on Photochemistry, Osaka, Japan.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912524
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments.
Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912526
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2016)
Comparison of different cultivation chamber designs for microfluidic bioreactors.
Chemie Ingenieur Technik 88(9): 1390.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912529
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion.
Presented at the EMBL Conference Microfluidics, Heidelberg, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912531
Westerwalbesloh C, Grünberger A, Kohlheyer D, von Lieres E (2016)
Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices.
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912536
Sachs CC, Probst C, Grünberger A, Wiechert W, Frunzke J, Kohlheyer D, Nöh K (2016)
An integrated platform for dynamic microfluidic experimentation with single-cell resolution.
Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912538
Steffens I, Grünberger A, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Bacterial phase diagrams. Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression.
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912540
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression.
Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany.
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2016 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912552
Probst C, Freier C, Mahr R, Grünberger A, Helfrich S, Wiechert W, Nöh K, Frunzke J, Kohlheyer D (2016)
Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms.
In: 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Red Hook, NY: Curran Associates, Inc.: 537-539.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912513
Kusen PM, Wandrey G, Probst C, Grünberger A, Holz M, Meyer zu Berstenhorst S, Kohlheyer D, Büchs J, Pietruszka J (2016)
Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine.
ACS chemical biology 11(10): 2915-2922.
PUB | DOI | WoS | PubMed | Europe PMC
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912525
Burmeister A, Bitzenhofer NL, Grünberger A, Binder D, Drepper T, Wiechert W (2016)
Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level.
Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912532
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Kohlheyer D, von Lieres E (2016)
Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells.
Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912537
Grünberger A, Wiechert W, Kohlheyer D (2016)
Bioprocesses under magnification. Learning from single cells about large-scale processes.
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912544
Binder D, Bier C, Grünberger A, Drobietz D, Hage-Hülsmann J, rey G, Büchs J, Kohlheyer D, Loeschcke A, Wiechert W, Jaeger K-E, Pietruszka J, Drepper T (2016)
Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression.
ChemBioChem 17(4): 296-299.
PUB | DOI | WoS | PubMed | Europe PMC
 
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912739
Li S, Jendresen CB, Grünberger A, Ronda C, Jensen SI, Noack S, Nielsen AT (2016)
Enhanced protein and biochemical production using CRISPRi-based growth switches.
Metabolic Engineering 38: 274-284.
PUB | DOI | WoS | PubMed | Europe PMC
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912760
Grünberger A (2016)
Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level.
Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912772
Grünberger A, Sachs C, Kohlheyer D, Wiechert W, Nöh K (2016)
Spatio-temporal analysis of bacterial populations at single-cell level.
Presented at the IBG Modelling Workshop, Jülich, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912511
Bier C, Binder D, Grünberger A, Drobietz D, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications.
Presented at the 18th International Conference on Photochemistry, Paris, France.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912523
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments.
Presented at the ProcessNet 2016, Aachen, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912530
Kaganovitch E, Probst C, Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D (2016)
Single-cell analysis of E. coli in microfluidic batch reactors.
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912535
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression.
Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904866
Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger K-E, Wendisch VF, Drepper T (2016)
Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum.
Appl Environ Microbiol 82: 6141-6149.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912554 OA
Krämer CEM, Singh A, Helfrich S, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2015)
Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester.
PLoS one 10(10): e0141768.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912541
Binder D, Bier C, Grünberger A, Loeschcke A, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T (2015)
Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications.
Presented at the ESP Photobiology conference, Aveiro, Portugal.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912546
Grünberger A, Wiechert W, Kohlheyer D (2015)
Single-cell microfluidics: A key technology to understand life at environmental defined conditions.
Presented at the Kick-off Konferenz: Leben? - Eine neue Förderinitiative stellt sich vor, Hannover, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912560
Zunic E, Schechtel A, Probst C, Grünberger A, Freier C, Seibold G, Wiechert W, Kohlheyer D (2015)
Dynamic environmental control in microfluidic devices for single-cell Analysis of biological production processes.
Presented at the Kolloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912565
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Single-cell microfluidics meets applied biotechnology. From expectation to application.
Presented at the Conference "Cell Factories and Biosustainability - Technologies for Cell Factory Construction", Hillerod, Denmark.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912584
Probst C, Grünberger A, Braun N, Helfrich S, Nöh K, Wiechert W, Kohlheyer D (2015)
Rapid inoculation of single bacteria into parallel picoliter fermentation chambers.
Analytical methods 7(1): 91-98.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912773
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Single-cell microfluidics meets applied biotechnology. From expectation to application.
Presented at the Jahreskongress Biotechnologie 2020+, Berlin, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912545
Loeschcke A, Thies S, Hage-Hülsmann J, Grünberger A, Binder D, Domröse A, Klein A, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T (2015)
Heterologous production of antibacterial secondary metabolites from Serratia marcescens in Pseudomonas putida.
Presented at the 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912548
Bier C, Binder D, Grünberger A, Drobietz D, Hage-Hülsmann J, Kohlheyer D, Loeschke A, Jaeger K-E, Drepper T, Pietruszka J (2015)
Caged Compounds for Biotechnological and Synthetic Biological Applications.
Presented at the European Society for Photobiology 2015 Congress, Aveiro, Portugal.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912550
Grünberger A, Probst C, Helfrich S, Nanda A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D (2015)
Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform.
Cytometry / A 87(12): 1101–1115.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912555
Helfrich S, Azzouzi CE, Probst C, Seiffarth J, Grünberger A, Wiechert W, Kohlheyer D, Nöh K (2015)
Vizardous: interactive analysis of microbial populations with single cell resolution.
Bioinformatics 31(23): 3875-3877.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912557 OA
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E (2015)
Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level.
Lab on a chip 15(21): 4177-4186.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912562
Grünberger A (2015)
Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar.
Biospektrum 21(3): 353-353.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912567
Grünberger A (2015)
Single-cell bioreactors: Improving the understanding of microbial metabolism.
Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany.
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2015 | Dissertation | Veröffentlicht | PUB-ID: 2912574 OA
Grünberger A (2015)
Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors. Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies; 114.
Jülich: RWTH Aachen.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912549
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2015)
Metabolite biosensors for single cell Analysis and the Evolution of production strains.
Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912551
Probst C, Grünberger A, Krämer C, Sachs CC, Wiechert W, Baumgart M, Kohlheyer D (2015)
Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging.
Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912556
Binder D, Probst C, Bier C, Loeschcke A, Grünberger A (2015)
Lichtgesteuerte Genexpression auf Einzelzellebene.
Biospektrum 21(6): 612-615.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912563
Sachs CC, Helfrich S, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2015)
High-throughput, long-term growth characterization of C. glutamicum on single cell level using the Mother Machine.
Presented at the 3rd International Conference of the Cluster of Excellence Tailor-Made Fuels from Biomass, Aachen, Germany.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912568
Dusny C, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Schmid A (2015)
Technical bias of microcultivation environments on single cell physiology.
Lab on a chip 15(8): 1822-1834.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912804
Krämer C, Helfrich S, Singh A, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2015)
Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants.
Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912763
Grünberger A (2015)
Microfluidic Single-Cell Cultivation: The key for next generation bioprocess development?
Presented at the Colloquium Biotechnology, Technical Faculty - Bielefeld University, Bielefeld.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912542
Probst C, Grünberger A, Binder D, Steffen I, Wiechert W, Kohlheyer D (2015)
Optical control of gene expression in bacteria on the single-cell level by caged compounds.
Presented at the Synthetic Biology: Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912559
Sachs CC, Helfrich S, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2015)
High-throughput long-term growth characterization of C. glutamicum on single cell using the Mother Machine.
Presented at the Colloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912566
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2015)
Single-Cell Bioreactors: Cutting Edge Cultivation Devices for the Ultimate Scale-Down of Bioprocesses.
Presented at the DECHEMA-Himmelfahrtstagung "Scale-up and scale-down of bioprocesses", Hamburg-Bergedorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912589
Helfrich S, Krämer C, Grünberger A, Azzouzi CE, Pfeifer E, Frunzke J, Wiechert W, Kohlheyer D, Nöh K (2014)
Microfluids as platform for the spatiotemporal analysis of bacterial populations at single-cell level.
Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912591
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Microfluidic Single-Cell Cultivation: Opportunity for Industrial Bioprocess Development.
Presented at the EMBL Conference – Microfluidics 2014, Heidelberg, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912596
Grünberger A, Probst C, Unthan S, Mustafi N, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Single-cell cultivation in picoliter scale: Opportunity for bioprocess development.
Presented at the 3rd BioProScale Symposium, Berlin, Germany.
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