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199 Publikationen

2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912524
Brehl, C., Grünberger, A., Probst, C., Pfaff, C., Wiechert, W., Behrendt, D., & Kohlheyer, D. (2016). Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments. Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912526
Westerwalbesloh, C., Grünberger, A., Wiechert, W., Kohlheyer, D., & von Lieres, E. (2016). Comparison of different cultivation chamber designs for microfluidic bioreactors. Chemie Ingenieur Technik, 88(9), 1390. doi:10.1002/cite.201650080
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912529
Grünberger, A., Steffens, I., Binder, D., Drepper, T., Wiechert, W., & Kohlheyer, D. (2016). Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion. Presented at the EMBL Conference Microfluidics, Heidelberg, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912531
Westerwalbesloh, C., Grünberger, A., Kohlheyer, D., & von Lieres, E. (2016). Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912536
Sachs, C. C., Probst, C., Grünberger, A., Wiechert, W., Frunzke, J., Kohlheyer, D., & Nöh, K. (2016). An integrated platform for dynamic microfluidic experimentation with single-cell resolution. Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912538
Steffens, I., Grünberger, A., Binder, D., Drepper, T., Wiechert, W., & Kohlheyer, D. (2016). Bacterial phase diagrams. Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912540
Grünberger, A., Steffens, I., Binder, D., Drepper, T., Wiechert, W., & Kohlheyer, D. (2016). Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression. Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany.
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2016 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912552
Probst, C., Freier, C., Mahr, R., Grünberger, A., Helfrich, S., Wiechert, W., Nöh, K., et al. (2016). Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms. 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015), 537-539. Red Hook, NY: Curran Associates, Inc.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912513
Kusen, P. M., Wandrey, G., Probst, C., Grünberger, A., Holz, M., Meyer zu Berstenhorst, S., Kohlheyer, D., et al. (2016). Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine. ACS chemical biology, 11(10), 2915-2922. doi:10.1021/acschembio.6b00462
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912525
Burmeister, A., Bitzenhofer, N. L., Grünberger, A., Binder, D., Drepper, T., & Wiechert, W. (2016). Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level. Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912532
Westerwalbesloh, C., Grünberger, A., Stute, B., Weber, S., Kohlheyer, D., & von Lieres, E. (2016). Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells. Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912537
Grünberger, A., Wiechert, W., & Kohlheyer, D. (2016). Bioprocesses under magnification. Learning from single cells about large-scale processes. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912544
Binder, D., Bier, C., Grünberger, A., Drobietz, D., Hage-Hülsmann, J., rey, G., Büchs, J., et al. (2016). Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression. ChemBioChem, 17(4), 296-299. doi:10.1002/cbic.201500609
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912739
Li, S., Jendresen, C. B., Grünberger, A., Ronda, C., Jensen, S. I., Noack, S., & Nielsen, A. T. (2016). Enhanced protein and biochemical production using CRISPRi-based growth switches. Metabolic Engineering, 38, 274-284. doi:10.1016/j.ymben.2016.09.003
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912760
Grünberger, A. (2016). Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level. Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912772
Grünberger, A., Sachs, C., Kohlheyer, D., Wiechert, W., & Nöh, K. (2016). Spatio-temporal analysis of bacterial populations at single-cell level. Presented at the IBG Modelling Workshop, Jülich, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912511
Bier, C., Binder, D., Grünberger, A., Drobietz, D., Kohlheyer, D., Löschcke, A., Jaeger, K. - E., et al. (2016). Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications. Presented at the 18th International Conference on Photochemistry, Paris, France.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912523
Brehl, C., Grünberger, A., Probst, C., Pfaff, C., Wiechert, W., Behrendt, D., & Kohlheyer, D. (2016). Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments. Presented at the ProcessNet 2016, Aachen, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912530
Kaganovitch, E., Probst, C., Westerwalbesloh, C., Grünberger, A., Wiechert, W., & Kohlheyer, D. (2016). Single-cell analysis of E. coli in microfluidic batch reactors. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912535
Grünberger, A., Steffens, I., Binder, D., Drepper, T., Wiechert, W., & Kohlheyer, D. (2016). Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression. Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904866
Binder, D., Frohwitter, J., Mahr, R., Bier, C., Grünberger, A., Loeschcke, A., Peters-Wendisch, P., et al. (2016). Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum. Appl Environ Microbiol, 82, 6141-6149. doi:10.1128/AEM.01457-16
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912554 OA
Krämer, C. E. M., Singh, A., Helfrich, S., Grünberger, A., Wiechert, W., Nöh, K., & Kohlheyer, D. (2015). Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester. PLoS one, 10(10), e0141768. doi:10.1371/journal.pone.0141768
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912541
Binder, D., Bier, C., Grünberger, A., Loeschcke, A., Kohlheyer, D., Pietruszka, J., Jaeger, K. - E., et al. (2015). Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications. Presented at the ESP Photobiology conference, Aveiro, Portugal.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912546
Grünberger, A., Wiechert, W., & Kohlheyer, D. (2015). Single-cell microfluidics: A key technology to understand life at environmental defined conditions. Presented at the Kick-off Konferenz: Leben? - Eine neue Förderinitiative stellt sich vor, Hannover, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912560
Zunic, E., Schechtel, A., Probst, C., Grünberger, A., Freier, C., Seibold, G., Wiechert, W., et al. (2015). Dynamic environmental control in microfluidic devices for single-cell Analysis of biological production processes. Presented at the Kolloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912565
Grünberger, A., Probst, C., Frunzke, J., Noack, S., Wiechert, W., & Kohlheyer, D. (2015). Single-cell microfluidics meets applied biotechnology. From expectation to application. Presented at the Conference "Cell Factories and Biosustainability - Technologies for Cell Factory Construction", Hillerod, Denmark.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912584
Probst, C., Grünberger, A., Braun, N., Helfrich, S., Nöh, K., Wiechert, W., & Kohlheyer, D. (2015). Rapid inoculation of single bacteria into parallel picoliter fermentation chambers. Analytical methods, 7(1), 91-98. doi:10.1039/C4AY02257b
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912773
Grünberger, A., Probst, C., Frunzke, J., Noack, S., Wiechert, W., & Kohlheyer, D. (2015). Single-cell microfluidics meets applied biotechnology. From expectation to application. Presented at the Jahreskongress Biotechnologie 2020+, Berlin, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912545
Loeschcke, A., Thies, S., Hage-Hülsmann, J., Grünberger, A., Binder, D., Domröse, A., Klein, A., et al. (2015). Heterologous production of antibacterial secondary metabolites from Serratia marcescens in Pseudomonas putida. Presented at the 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912548
Bier, C., Binder, D., Grünberger, A., Drobietz, D., Hage-Hülsmann, J., Kohlheyer, D., Loeschke, A., et al. (2015). Caged Compounds for Biotechnological and Synthetic Biological Applications. Presented at the European Society for Photobiology 2015 Congress, Aveiro, Portugal.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912550
Grünberger, A., Probst, C., Helfrich, S., Nanda, A., Stute, B., Wiechert, W., von Lieres, E., et al. (2015). Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform. Cytometry / A, 87(12), 1101–1115. doi:10.1002/cyto.a.22779
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912555
Helfrich, S., Azzouzi, C. E., Probst, C., Seiffarth, J., Grünberger, A., Wiechert, W., Kohlheyer, D., et al. (2015). Vizardous: interactive analysis of microbial populations with single cell resolution. Bioinformatics, 31(23), 3875-3877. doi:10.1093/bioinformatics/btv468
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912557 OA
Westerwalbesloh, C., Grünberger, A., Stute, B., Weber, S., Wiechert, W., Kohlheyer, D., & von Lieres, E. (2015). Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level. Lab on a chip, 15(21), 4177-4186. doi:10.1039/C5LC00646e
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912562
Grünberger, A. (2015). Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar. Biospektrum, 21(3), 353-353. doi:10.1007/s12268-015-0585-8
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912567
Grünberger, A. (2015). Single-cell bioreactors: Improving the understanding of microbial metabolism. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany.
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2015 | Dissertation | Veröffentlicht | PUB-ID: 2912574 OA
Grünberger, A. (2015). Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors (Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies, 114). Jülich: RWTH Aachen.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912549
Mahr, R., Mustafi, N., Grünberger, A., Helfrich, S., Nöh, K., Kohlheyer, D., & Frunzke, J. (2015). Metabolite biosensors for single cell Analysis and the Evolution of production strains. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912551
Probst, C., Grünberger, A., Krämer, C., Sachs, C. C., Wiechert, W., Baumgart, M., & Kohlheyer, D. (2015). Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging. Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912556
Binder, D., Probst, C., Bier, C., Loeschcke, A., & Grünberger, A. (2015). Lichtgesteuerte Genexpression auf Einzelzellebene. Biospektrum, 21(6), 612-615. doi:10.1007/s12268-015-0622-7
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912563
Sachs, C. C., Helfrich, S., Grünberger, A., Probst, C., Wiechert, W., Kohlheyer, D., & Nöh, K. (2015). High-throughput, long-term growth characterization of C. glutamicum on single cell level using the Mother Machine. Presented at the 3rd International Conference of the Cluster of Excellence Tailor-Made Fuels from Biomass, Aachen, Germany.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912568
Dusny, C., Grünberger, A., Probst, C., Wiechert, W., Kohlheyer, D., & Schmid, A. (2015). Technical bias of microcultivation environments on single cell physiology. Lab on a chip, 15(8), 1822-1834. doi:10.1039/C4LC01270D
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912804
Krämer, C., Helfrich, S., Singh, A., Grünberger, A., Wiechert, W., Nöh, K., & Kohlheyer, D. (2015). Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants. Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912763
Grünberger, A. (2015). Microfluidic Single-Cell Cultivation: The key for next generation bioprocess development?. Presented at the Colloquium Biotechnology, Technical Faculty - Bielefeld University, Bielefeld.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912542
Probst, C., Grünberger, A., Binder, D., Steffen, I., Wiechert, W., & Kohlheyer, D. (2015). Optical control of gene expression in bacteria on the single-cell level by caged compounds. Presented at the Synthetic Biology: Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912559
Sachs, C. C., Helfrich, S., Grünberger, A., Probst, C., Wiechert, W., Kohlheyer, D., & Nöh, K. (2015). High-throughput long-term growth characterization of C. glutamicum on single cell using the Mother Machine. Presented at the Colloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912566
Grünberger, A., Probst, C., Wiechert, W., & Kohlheyer, D. (2015). Single-Cell Bioreactors: Cutting Edge Cultivation Devices for the Ultimate Scale-Down of Bioprocesses. Presented at the DECHEMA-Himmelfahrtstagung "Scale-up and scale-down of bioprocesses", Hamburg-Bergedorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912589
Helfrich, S., Krämer, C., Grünberger, A., Azzouzi, C. E., Pfeifer, E., Frunzke, J., Wiechert, W., et al. (2014). Microfluids as platform for the spatiotemporal analysis of bacterial populations at single-cell level. Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912591
Grünberger, A., Probst, C., Frunzke, J., Noack, S., Wiechert, W., & Kohlheyer, D. (2014). Microfluidic Single-Cell Cultivation: Opportunity for Industrial Bioprocess Development. Presented at the EMBL Conference – Microfluidics 2014, Heidelberg, Germany.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912596
Grünberger, A., Probst, C., Unthan, S., Mustafi, N., Frunzke, J., Noack, S., Wiechert, W., et al. (2014). Single-cell cultivation in picoliter scale: Opportunity for bioprocess development. Presented at the 3rd BioProScale Symposium, Berlin, Germany.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912616
Unthan, S., Grünberger, A., van Ooyen, J., Gätgens, J., Heinrich, J., Paczia, N., Wiechert, W., et al. (2014). Beyond growth rate 0.6. What drives Corynebacterium glutamicum to higher growth rates in defined medium. Biotechnology and bioengineering, 111(2), 359–371. doi:10.1002/bit.25103
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