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199 Publikationen

2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912509
Rudat, Annika, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Grünberger, Alexander. 2017. “Microfluidic cultivation chamber for the investigation of synthetic microbial co-cultures on single-cell level: From the development to first application”. Presented at the BioProcessing Days 2017, Recklinghausen, Germany .
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912522
Sachs, Christian Carsten, Grünberger, Alexander, Helfrich, Stefan, Probst, Christopher, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. 2016. “Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments”. PLoS one 11 (9): e0163453 -.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912514
Binder, Dennis, Probst, Christopher, Grünberger, Alexander, Hilgers, Fabienne, Loeschcke, Anita, Jaeger, Karl-Erich, Kohlheyer, Dietrich, and Drepper, Thomas. 2016. “Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation”. PLoS one 11 (8): e0160711.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912820
Hage-Hülsmann, Jenny, Grünberger, Alexander, Thies, Stephan, Domröse, Andreas, Klein, Andreas, Binder, Dennis, Hilgers, Fabienne, et al. 2016. “Combinatorial antibiotic effects of natural biocide cocktails”. Presented at the IV International Conference on Antimicrobial Research, Malaga, Spain .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912527
Grünberger, Alexander. 2016. “Microfluidic single-cell cultivation: Is small the new beautiful?”. Presented at the 6th International Bielefeld-CeBiTec Research Conference: Advances in Industrial Biotechnology: New Techniques, Substrates and Products for Bioprocesses, Bielefeld, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912534
Grünberger, Alexander. 2016. “Single-cell microfluidics for bioprocess development”. Presented at the GreenWin Conferences “Green Chemistry and White Biotechnology", Gembloux, Belgium .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912539
Westerwalbesloh, Christoph, Grünberger, Alexander, Stute, Birgit, Weber, Sophie, Wiechert, Wolfgang, Kohlheyer, Dietrich, and von Lieres, Eric. 2016. “Nutrient distribution in perfusion based picoliter bioreactors”. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912761
Grünberger, Alexander. 2016. “Microfluidic single-cell bioreactors. Introduction, application and future perspectives”. Presented at the LCSB Biannual Minisymposia in Modelling/Automation/Microfluidics at the University of Luxembourg, Esch-sur-Alzette, Luxembourg .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912803
Binder, Dennis, Bier, Claus, Grünberger, Alexander, Hilgers, F., Loeschcke, Anita, Kohlheyer, Dietrich, Pietruszka, Jörg, Jaeger, Karl Erich, and Drepper, Thomas. 2016. “Employing photocaged carbohydrates in light-controlled cell factories for synthetic bio(techno)logy and single cell applications”. Presented at the Annual Conference of the Association for General and Applied Microbiology (VAAM),, Jena, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912512
Bier, Claus, Binder, Dennis, Grünberger, Alexander, Drobietz, Dagmar, Hage-Hülsmann, Jennifer, Kohlheyer, Dietrich, Löschcke, Anita, Jaeger, Karl-Erich, Drepper, Thomas, and Pietruszka, Jörg. 2016. “Sugar Based Caged Compounds for Biotechnological Synthetic Biological Applications”. Presented at the 26th IUPAC Symposium on Photochemistry, Osaka, Japan .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912524
Brehl, Carl, Grünberger, Alexander, Probst, Christopher, Pfaff, Christian, Wiechert, Wolfgang, Behrendt, Dominik, and Kohlheyer, Dietrich. 2016. “Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments”. Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912526
Westerwalbesloh, Christoph, Grünberger, Alexander, Wiechert, Wolfgang, Kohlheyer, Dietrich, and von Lieres, Eric. 2016. “Comparison of different cultivation chamber designs for microfluidic bioreactors”, Chemie Ingenieur Technik, 88 (9): 1390.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912529
Grünberger, Alexander, Steffens, Iska, Binder, Dennis, Drepper, Thomas, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2016. “Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion”. Presented at the EMBL Conference Microfluidics, Heidelberg, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912531
Westerwalbesloh, Christoph, Grünberger, Alexander, Kohlheyer, Dietrich, and von Lieres, Eric. 2016. “Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices”. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912536
Sachs, Christian Carsten, Probst, Christopher, Grünberger, Alexander, Wiechert, Wolfgang, Frunzke, Julia, Kohlheyer, Dietrich, and Nöh, Katharina. 2016. “An integrated platform for dynamic microfluidic experimentation with single-cell resolution”. Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912538
Steffens, Iska, Grünberger, Alexander, Binder, Dennis, Drepper, Thomas, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2016. “Bacterial phase diagrams. Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression”. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany) .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912540
Grünberger, Alexander, Steffens, Iska, Binder, Dennis, Drepper, Thomas, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2016. “Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression”. Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany .
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2016 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912552
Probst, Christopher, Freier, Christian, Mahr, Regina, Grünberger, Alexander, Helfrich, Stefan, Wiechert, Wolfgang, Nöh, Katharina, Frunzke, Julia, and Kohlheyer, Dietrich. 2016. “Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms”. In 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015), 537-539. Red Hook, NY: Curran Associates, Inc.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912739
Li, Songyuan, Jendresen, Christian Bille, Grünberger, Alexander, Ronda, Carlotta, Jensen, Sheila Ingemann, Noack, Stephan, and Nielsen, Alex Toftgaard. 2016. “Enhanced protein and biochemical production using CRISPRi-based growth switches”. Metabolic Engineering 38: 274-284.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912760
Grünberger, Alexander. 2016. “Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level”. Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912772
Grünberger, Alexander, Sachs, Christian, Kohlheyer, Dietrich, Wiechert, Wolfgang, and Nöh, Katharina. 2016. “Spatio-temporal analysis of bacterial populations at single-cell level”. Presented at the IBG Modelling Workshop, Jülich, Germany .
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912513
Kusen, Peter M., Wandrey, Georg, Probst, Christopher, Grünberger, Alexander, Holz, Martina, Meyer zu Berstenhorst, Sonja, Kohlheyer, Dietrich, Büchs, Jochen, and Pietruszka, Jörg. 2016. “Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine”. ACS chemical biology 11 (10): 2915-2922.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912525
Burmeister, Alina, Bitzenhofer, N. L., Grünberger, Alexander, Binder, Dennis, Drepper, Thomas, and Wiechert, Wolfgang. 2016. “Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level”. Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912532
Westerwalbesloh, Christoph, Grünberger, Alexander, Stute, Birgit, Weber, Sophie, Kohlheyer, Dietrich, and von Lieres, Eric. 2016. “Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells”. Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912537
Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2016. “Bioprocesses under magnification. Learning from single cells about large-scale processes”. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany .
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912544
Binder, Dennis, Bier, Claus, Grünberger, Alexander, Drobietz, Dagmar, Hage-Hülsmann, Jennifer, rey, Georg, Büchs, Jochen, et al. 2016. “Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression”. ChemBioChem 17 (4): 296-299.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912511
Bier, Claus, Binder, Dennis, Grünberger, Alexander, Drobietz, Dagmar, Kohlheyer, Dietrich, Löschcke, Anita, Jaeger, Karl-Erich, Drepper, Thomas, and Pietruszka, Jörg. 2016. “Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications”. Presented at the 18th International Conference on Photochemistry, Paris, France .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912523
Brehl, Carl, Grünberger, Alexander, Probst, Christopher, Pfaff, Christian, Wiechert, Wolfgang, Behrendt, Dominik, and Kohlheyer, Dietrich. 2016. “Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments”. Presented at the ProcessNet 2016, Aachen, Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912530
Kaganovitch, Eugen, Probst, Christopher, Westerwalbesloh, Christoph, Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2016. “Single-cell analysis of E. coli in microfluidic batch reactors”. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany .
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912535
Grünberger, Alexander, Steffens, Iska, Binder, Dennis, Drepper, Thomas, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2016. “Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression”. Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany .
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904866
Binder, Dennis, Frohwitter, Jonas, Mahr, Regina, Bier, Claus, Grünberger, Alexander, Loeschcke, Anita, Peters-Wendisch, Petra, et al. 2016. “Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum”. Appl Environ Microbiol 82: 6141-6149.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912554
Krämer, Christina E. M., Singh, Abhijeet, Helfrich, Stefan, Grünberger, Alexander, Wiechert, Wolfgang, Nöh, Katharina, and Kohlheyer, Dietrich. 2015. “Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester”. PLoS one 10 (10): e0141768.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912584
Probst, Christopher, Grünberger, Alexander, Braun, Nadja, Helfrich, Stefan, Nöh, Katharina, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2015. “Rapid inoculation of single bacteria into parallel picoliter fermentation chambers”. Analytical methods 7 (1): 91-98.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912541
Binder, Dennis, Bier, Claus, Grünberger, Alexander, Loeschcke, Anita, Kohlheyer, Dietrich, Pietruszka, Jörg, Jaeger, Karl-Erich, and Drepper, Thomas. 2015. “Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications”. Presented at the ESP Photobiology conference, Aveiro, Portugal .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912546
Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2015. “Single-cell microfluidics: A key technology to understand life at environmental defined conditions”. Presented at the Kick-off Konferenz: Leben? - Eine neue Förderinitiative stellt sich vor, Hannover, Germany .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912560
Zunic, Ena, Schechtel, Anna, Probst, Christopher, Grünberger, Alexander, Freier, Christian, Seibold, Gerd, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2015. “Dynamic environmental control in microfluidic devices for single-cell Analysis of biological production processes”. Presented at the Kolloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912565
Grünberger, Alexander, Probst, Christopher, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2015. “Single-cell microfluidics meets applied biotechnology. From expectation to application”. Presented at the Conference "Cell Factories and Biosustainability - Technologies for Cell Factory Construction", Hillerod, Denmark .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912773
Grünberger, Alexander, Probst, Christopher, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2015. “Single-cell microfluidics meets applied biotechnology. From expectation to application”. Presented at the Jahreskongress Biotechnologie 2020+, Berlin, Germany .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912545
Loeschcke, Anita, Thies, Stephan, Hage-Hülsmann, Jennifer, Grünberger, Alexander, Binder, Dennis, Domröse, Andreas, Klein, Andreas, et al. 2015. “Heterologous production of antibacterial secondary metabolites from Serratia marcescens in Pseudomonas putida”. Presented at the 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912548
Bier, Claus, Binder, Dennis, Grünberger, Alexander, Drobietz, Dagmar, Hage-Hülsmann, Jennifer, Kohlheyer, Dietrich, Loeschke, Anita, Jaeger, Karl-Erich, Drepper, Thomas, and Pietruszka, Jörg. 2015. “Caged Compounds for Biotechnological and Synthetic Biological Applications”. Presented at the European Society for Photobiology 2015 Congress, Aveiro, Portugal .
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912550
Grünberger, Alexander, Probst, Christopher, Helfrich, Stefan, Nanda, Arun, Stute, Birgit, Wiechert, Wolfgang, von Lieres, Eric, Nöh, Katharina, Frunzke, Julia, and Kohlheyer, Dietrich. 2015. “Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform”. Cytometry / A 87 (12): 1101–1115.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912555
Helfrich, Stefan, Azzouzi, Charaf E., Probst, Christopher, Seiffarth, Johannes, Grünberger, Alexander, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. 2015. “Vizardous: interactive analysis of microbial populations with single cell resolution”. Bioinformatics 31 (23): 3875-3877.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912557
Westerwalbesloh, Christoph, Grünberger, Alexander, Stute, Birgit, Weber, Sophie, Wiechert, Wolfgang, Kohlheyer, Dietrich, and von Lieres, Eric. 2015. “Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level”. Lab on a chip 15 (21): 4177-4186.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912562
Grünberger, Alexander. 2015. “Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar”. Biospektrum 21 (3): 353-353.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912567
Grünberger, Alexander. 2015. “Single-cell bioreactors: Improving the understanding of microbial metabolism”. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany .
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2015 | Dissertation | Veröffentlicht | PUB-ID: 2912574
Grünberger, Alexander. 2015. Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors. Vol. 114. Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies. Jülich: RWTH Aachen.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912804
Krämer, Christina, Helfrich, Stefan, Singh, Abhijeet, Grünberger, Alexander, Wiechert, Wolfgang, Nöh, Katharina, and Kohlheyer, Dietrich. 2015. “Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants”. Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912549
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. 2015. “Metabolite biosensors for single cell Analysis and the Evolution of production strains”. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany .
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912551
Probst, Christopher, Grünberger, Alexander, Krämer, Christina, Sachs, Christian Carsten, Wiechert, Wolfgang, Baumgart, Meike, and Kohlheyer, Dietrich. 2015. “Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging”. Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany .
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912556
Binder, Dennis, Probst, Christopher, Bier, Claus, Loeschcke, Anita, and Grünberger, Alexander. 2015. “Lichtgesteuerte Genexpression auf Einzelzellebene”. Biospektrum 21 (6): 612-615.
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