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200 Publikationen

2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912771
Rudat A, Noack S, Wiechert W, Kohlheyer D, Grünberger A (2017)
Microfluidic single-cell (co-)cultivation: Exploring the next dimension.
Presented at the Data-driven Biotechnology - bench, bioreactor and bedside, Copenhagen, Denmark.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912502
Jäger VD, Longerich S, Dietrich M, Kloss R, Grünberger A, Pohl M, Jaeger K-E, Krauss U (2017)
Functionally-active protein aggregates - towards the realization of an enzyme cascade in catalytically-active inclusion bodies.
Presented at the BioTrans 2017, Budapest, Hungary.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912505
Sachs CC, Koepff J, Kohlheyer D, Wiechert W, Oldiges M, Nöh K, Grünberger A (2017)
Microfluidic single-cell cultivation of S. lividans: Uncovering heterogeneity in filamentous growth.
Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912507
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Spatiotemporal analysis of synthetic microbial communities at the single-cell level in microfluidic interaction compartments.
Presented at the 6th International Conference on Microbial Communication for Young Scientists, Jena, Germany.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912521
Grünberger A, Schöler K, Probst C, Kornfeld G, Hardiman T, Wiechert W, Kohlheyer D, Noack S (2017)
Real-time monitoring of fungal growth and morphogenesis at single-cell resolution.
Engineering in life sciences 17(1): 86–92.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912501
Kloss R, Limberg M, Jäger VD, Mackfeld U, Karmainski T, Grünberger A, Krauss U, Pohl M (2017)
Catalytically active inclusion bodies. A novel carrier-free Enzyme Immobilisation method.
Presented at the BioTrans 2017, Budapest, Hungary.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912506
Sachs CC, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2017)
Integrated High-Throughput Platform for Microfluidic Live-Cell Analysis with Feed-Back Eyperimentation.
Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
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2017 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912518
Kaganovitch E, Krischer M, Probst C, Grünberger A, Zunic E, Freier C, Wiechert W, Kohlheyer D (2017)
Microfluidic device for control and sensing of dynamic oxygen levels during cell cultivation.
In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.: 355-356.
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2017 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2912520
Ladner T, Grünberger A, Probst C, Kohlheyer D, Büchs J, Delvigne F (2017)
Application of Mini- and Micro-Bioreactors for Microbial Bioprocesses.
In: Current Developments in Biotechnology and Bioengineering. Larroche C, Sanromán MÁ, Du G, Pandey A (Eds); Amsterdam: Elsevier: 433-461.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912737
Delvigne F, Baert J, Sassi H, Fickers P, Grünberger A, Dusny C (2017)
Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses.
Biotechnology Journal 12(7): 1600549.
PUB | DOI | WoS | PubMed | Europe PMC
 
2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912504
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2017)
Models for Developing and Optimizing Microscale Bacteria Cultivation.
Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912509
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Microfluidic cultivation chamber for the investigation of synthetic microbial co-cultures on single-cell level: From the development to first application.
Presented at the BioProcessing Days 2017, Recklinghausen, Germany.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912522 OA
Sachs CC, Grünberger A, Helfrich S, Probst C, Wiechert W, Kohlheyer D, Nöh K (2016)
Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments.
PLoS one 11(9): e0163453 -.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912514 OA
Binder D, Probst C, Grünberger A, Hilgers F, Loeschcke A, Jaeger K-E, Kohlheyer D, Drepper T (2016)
Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation.
PLoS one 11(8): e0160711.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912820
Hage-Hülsmann J, Grünberger A, Thies S, Domröse A, Klein A, Binder D, Hilgers F, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T, Loeschcke A (2016)
Combinatorial antibiotic effects of natural biocide cocktails.
Presented at the IV International Conference on Antimicrobial Research, Malaga, Spain.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912527
Grünberger A (2016)
Microfluidic single-cell cultivation: Is small the new beautiful?
Presented at the 6th International Bielefeld-CeBiTec Research Conference: Advances in Industrial Biotechnology: New Techniques, Substrates and Products for Bioprocesses, Bielefeld, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912534
Grünberger A (2016)
Single-cell microfluidics for bioprocess development.
Presented at the GreenWin Conferences “Green Chemistry and White Biotechnology", Gembloux, Belgium.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912539
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E (2016)
Nutrient distribution in perfusion based picoliter bioreactors.
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912761
Grünberger A (2016)
Microfluidic single-cell bioreactors. Introduction, application and future perspectives.
Presented at the LCSB Biannual Minisymposia in Modelling/Automation/Microfluidics at the University of Luxembourg, Esch-sur-Alzette, Luxembourg.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912803
Binder D, Bier C, Grünberger A, Hilgers F, Loeschcke A, Kohlheyer D, Pietruszka J, Jaeger KE, Drepper T (2016)
Employing photocaged carbohydrates in light-controlled cell factories for synthetic bio(techno)logy and single cell applications.
Presented at the Annual Conference of the Association for General and Applied Microbiology (VAAM),, Jena, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912512
Bier C, Binder D, Grünberger A, Drobietz D, Hage-Hülsmann J, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Sugar Based Caged Compounds for Biotechnological Synthetic Biological Applications.
Presented at the 26th IUPAC Symposium on Photochemistry, Osaka, Japan.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912524
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments.
Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912526
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2016)
Comparison of different cultivation chamber designs for microfluidic bioreactors.
Chemie Ingenieur Technik 88(9): 1390.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912529
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion.
Presented at the EMBL Conference Microfluidics, Heidelberg, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912531
Westerwalbesloh C, Grünberger A, Kohlheyer D, von Lieres E (2016)
Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices.
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912536
Sachs CC, Probst C, Grünberger A, Wiechert W, Frunzke J, Kohlheyer D, Nöh K (2016)
An integrated platform for dynamic microfluidic experimentation with single-cell resolution.
Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912538
Steffens I, Grünberger A, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Bacterial phase diagrams. Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression.
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912540
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression.
Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany.
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2016 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912552
Probst C, Freier C, Mahr R, Grünberger A, Helfrich S, Wiechert W, Nöh K, Frunzke J, Kohlheyer D (2016)
Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms.
In: 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Red Hook, NY: Curran Associates, Inc.: 537-539.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912513
Kusen PM, Wandrey G, Probst C, Grünberger A, Holz M, Meyer zu Berstenhorst S, Kohlheyer D, Büchs J, Pietruszka J (2016)
Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine.
ACS chemical biology 11(10): 2915-2922.
PUB | DOI | WoS | PubMed | Europe PMC
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912525
Burmeister A, Bitzenhofer NL, Grünberger A, Binder D, Drepper T, Wiechert W (2016)
Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level.
Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912532
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Kohlheyer D, von Lieres E (2016)
Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells.
Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912537
Grünberger A, Wiechert W, Kohlheyer D (2016)
Bioprocesses under magnification. Learning from single cells about large-scale processes.
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912544
Binder D, Bier C, Grünberger A, Drobietz D, Hage-Hülsmann J, rey G, Büchs J, Kohlheyer D, Loeschcke A, Wiechert W, Jaeger K-E, Pietruszka J, Drepper T (2016)
Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression.
ChemBioChem 17(4): 296-299.
PUB | DOI | WoS | PubMed | Europe PMC
 
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912739
Li S, Jendresen CB, Grünberger A, Ronda C, Jensen SI, Noack S, Nielsen AT (2016)
Enhanced protein and biochemical production using CRISPRi-based growth switches.
Metabolic Engineering 38: 274-284.
PUB | DOI | WoS | PubMed | Europe PMC
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912760
Grünberger A (2016)
Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level.
Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912772
Grünberger A, Sachs C, Kohlheyer D, Wiechert W, Nöh K (2016)
Spatio-temporal analysis of bacterial populations at single-cell level.
Presented at the IBG Modelling Workshop, Jülich, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912511
Bier C, Binder D, Grünberger A, Drobietz D, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications.
Presented at the 18th International Conference on Photochemistry, Paris, France.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912523
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments.
Presented at the ProcessNet 2016, Aachen, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912530
Kaganovitch E, Probst C, Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D (2016)
Single-cell analysis of E. coli in microfluidic batch reactors.
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912535
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression.
Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904866
Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger K-E, Wendisch VF, Drepper T (2016)
Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum.
Appl Environ Microbiol 82: 6141-6149.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912554 OA
Krämer CEM, Singh A, Helfrich S, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2015)
Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester.
PLoS one 10(10): e0141768.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912541
Binder D, Bier C, Grünberger A, Loeschcke A, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T (2015)
Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications.
Presented at the ESP Photobiology conference, Aveiro, Portugal.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912546
Grünberger A, Wiechert W, Kohlheyer D (2015)
Single-cell microfluidics: A key technology to understand life at environmental defined conditions.
Presented at the Kick-off Konferenz: Leben? - Eine neue Förderinitiative stellt sich vor, Hannover, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912560
Zunic E, Schechtel A, Probst C, Grünberger A, Freier C, Seibold G, Wiechert W, Kohlheyer D (2015)
Dynamic environmental control in microfluidic devices for single-cell Analysis of biological production processes.
Presented at the Kolloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912565
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Single-cell microfluidics meets applied biotechnology. From expectation to application.
Presented at the Conference "Cell Factories and Biosustainability - Technologies for Cell Factory Construction", Hillerod, Denmark.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912584
Probst C, Grünberger A, Braun N, Helfrich S, Nöh K, Wiechert W, Kohlheyer D (2015)
Rapid inoculation of single bacteria into parallel picoliter fermentation chambers.
Analytical methods 7(1): 91-98.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912773
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Single-cell microfluidics meets applied biotechnology. From expectation to application.
Presented at the Jahreskongress Biotechnologie 2020+, Berlin, Germany.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912545
Loeschcke A, Thies S, Hage-Hülsmann J, Grünberger A, Binder D, Domröse A, Klein A, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T (2015)
Heterologous production of antibacterial secondary metabolites from Serratia marcescens in Pseudomonas putida.
Presented at the 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands.
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