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199 Publikationen

2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920685
Mosheiff, N., Martins, B.M.C., Pearl-Mizrahi, S., Grünberger, A., Helfrich, S., Mihalcescu, I., Kohlheyer, D., Locke, J.C.W., Glass, L., Balaban, N.Q.: Inheritance of Cell-Cycle Duration in the Presence of Periodic Forcing. PHYSICAL REVIEW X. 8, : 15 (2018).
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2018 | Bielefelder E-Dissertation | PUB-ID: 2919683 OA
Radek, A.: Establishing the Weimberg pathway in Corynebacterium glutamicum as an alternative route for D-xylose utilization. Universität Bielefeld, Bielefeld (2018).
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2931505
Jaeger, V.D., Lamm, R., Kloss, R., Kaganovitch, E., Grünberger, A., Pohl, M., Buechs, J., Jaeger, K.-E., Krauss, U.: A Synthetic Reaction Cascade Implemented by Colocalization of Two Proteins within Catalytically Active Inclusion Bodies. ACS SYNTHETIC BIOLOGY. 7, 2282-2295 (2018).
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2919063
Dormeyer, M., Lentes, S., Ballin, P., Wilkens, M., Klumpp, S., Kohlheyer, D., Stannek, L., Grünberger, A., Commichau, F.M.: Visualization of tandem repeat mutagenesis in Bacillus subtilis. DNA REPAIR. 63, 10-15 (2018).
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912738
Westerwalbesloh, C., Grünberger, A., Wiechert, W., Kohlheyer, D., von Lieres, E.: Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level. Microbial Biotechnology. 10, 845-857 (2017).
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916519
Binder, D., Drepper, T., Jaeger, K.-E., Delvigne, F., Wiechert, W., Kohlheyer, D., Grünberger, A.: Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity. METABOLIC ENGINEERING. 42, 145-156 (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912503
Rudat, A., Wiechert, W., Kohlheyer, D., Grünberger, A.: Picoliter bioreactors for microbial consortia: From proof of concept to first application. Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912508
Burmeister, A., Bitzenhofer, N.L., Grünberger, A., Binder, D., Drepper, T., Wiechert, W., Kohlheyer, D.: Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level. Presented at the BioProcessing Days 2017, Recklinghausen, Germany (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912759
Grünberger, A.: Microfluidic Single-Cell Cultivation: A key for next generation bioprocess development? Presented at the FFBiotech Symposium - Innovative approaches in bioreactors design and operation, Lille, France (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912771
Rudat, A., Noack, S., Wiechert, W., Kohlheyer, D., Grünberger, A.: Microfluidic single-cell (co-)cultivation: Exploring the next dimension. Presented at the Data-driven Biotechnology - bench, bioreactor and bedside, Copenhagen, Denmark (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912502
Jäger, V.D., Longerich, S., Dietrich, M., Kloss, R., Grünberger, A., Pohl, M., Jaeger, K.-E., Krauss, U.: Functionally-active protein aggregates - towards the realization of an enzyme cascade in catalytically-active inclusion bodies. Presented at the BioTrans 2017, Budapest, Hungary (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912505
Sachs, C.C., Koepff, J., Kohlheyer, D., Wiechert, W., Oldiges, M., Nöh, K., Grünberger, A.: Microfluidic single-cell cultivation of S. lividans: Uncovering heterogeneity in filamentous growth. Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912507
Rudat, A., Wiechert, W., Kohlheyer, D., Grünberger, A.: Spatiotemporal analysis of synthetic microbial communities at the single-cell level in microfluidic interaction compartments. Presented at the 6th International Conference on Microbial Communication for Young Scientists, Jena, Germany (2017).
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912521
Grünberger, A., Schöler, K., Probst, C., Kornfeld, G., Hardiman, T., Wiechert, W., Kohlheyer, D., Noack, S.: Real-time monitoring of fungal growth and morphogenesis at single-cell resolution. Engineering in life sciences. 17, 86–92 (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912501
Kloss, R., Limberg, M., Jäger, V.D., Mackfeld, U., Karmainski, T., Grünberger, A., Krauss, U., Pohl, M.: Catalytically active inclusion bodies. A novel carrier-free Enzyme Immobilisation method. Presented at the BioTrans 2017, Budapest, Hungary (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912506
Sachs, C.C., Grünberger, A., Probst, C., Wiechert, W., Kohlheyer, D., Nöh, K.: Integrated High-Throughput Platform for Microfluidic Live-Cell Analysis with Feed-Back Eyperimentation. Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany (2017).
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2017 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912518
Kaganovitch, E., Krischer, M., Probst, C., Grünberger, A., Zunic, E., Freier, C., Wiechert, W., Kohlheyer, D.: Microfluidic device for control and sensing of dynamic oxygen levels during cell cultivation. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). p. 355-356. Curran Associates, Inc., Red Hook, NY (2017).
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2017 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2912520
Ladner, T., Grünberger, A., Probst, C., Kohlheyer, D., Büchs, J., Delvigne, F.: Application of Mini- and Micro-Bioreactors for Microbial Bioprocesses. In: Larroche, C., Sanromán, M.Á., Du, G., and Pandey, A. (eds.) Current Developments in Biotechnology and Bioengineering. p. 433-461. Elsevier, Amsterdam (2017).
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912737
Delvigne, F., Baert, J., Sassi, H., Fickers, P., Grünberger, A., Dusny, C.: Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses. Biotechnology Journal. 12, : 1600549 (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912504
Westerwalbesloh, C., Grünberger, A., Wiechert, W., Kohlheyer, D., von Lieres, E.: Models for Developing and Optimizing Microscale Bacteria Cultivation. Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany (2017).
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912509
Rudat, A., Wiechert, W., Kohlheyer, D., Grünberger, A.: Microfluidic cultivation chamber for the investigation of synthetic microbial co-cultures on single-cell level: From the development to first application. Presented at the BioProcessing Days 2017, Recklinghausen, Germany (2017).
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912522 OA
Sachs, C.C., Grünberger, A., Helfrich, S., Probst, C., Wiechert, W., Kohlheyer, D., Nöh, K.: Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments. PLoS one. 11, : e0163453 - (2016).
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912514 OA
Binder, D., Probst, C., Grünberger, A., Hilgers, F., Loeschcke, A., Jaeger, K.-E., Kohlheyer, D., Drepper, T.: Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation. PLoS one. 11, : e0160711 (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912820
Hage-Hülsmann, J., Grünberger, A., Thies, S., Domröse, A., Klein, A., Binder, D., Hilgers, F., Kohlheyer, D., Pietruszka, J., Jaeger, K.-E., Drepper, T., Loeschcke, A.: Combinatorial antibiotic effects of natural biocide cocktails. Presented at the IV International Conference on Antimicrobial Research, Malaga, Spain (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912527
Grünberger, A.: Microfluidic single-cell cultivation: Is small the new beautiful? Presented at the 6th International Bielefeld-CeBiTec Research Conference: Advances in Industrial Biotechnology: New Techniques, Substrates and Products for Bioprocesses, Bielefeld, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912534
Grünberger, A.: Single-cell microfluidics for bioprocess development. Presented at the GreenWin Conferences “Green Chemistry and White Biotechnology", Gembloux, Belgium (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912539
Westerwalbesloh, C., Grünberger, A., Stute, B., Weber, S., Wiechert, W., Kohlheyer, D., von Lieres, E.: Nutrient distribution in perfusion based picoliter bioreactors. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912761
Grünberger, A.: Microfluidic single-cell bioreactors. Introduction, application and future perspectives. Presented at the LCSB Biannual Minisymposia in Modelling/Automation/Microfluidics at the University of Luxembourg, Esch-sur-Alzette, Luxembourg (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912803
Binder, D., Bier, C., Grünberger, A., Hilgers, F., Loeschcke, A., Kohlheyer, D., Pietruszka, J., Jaeger, K.E., Drepper, T.: Employing photocaged carbohydrates in light-controlled cell factories for synthetic bio(techno)logy and single cell applications. Presented at the Annual Conference of the Association for General and Applied Microbiology (VAAM),, Jena, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912512
Bier, C., Binder, D., Grünberger, A., Drobietz, D., Hage-Hülsmann, J., Kohlheyer, D., Löschcke, A., Jaeger, K.-E., Drepper, T., Pietruszka, J.: Sugar Based Caged Compounds for Biotechnological Synthetic Biological Applications. Presented at the 26th IUPAC Symposium on Photochemistry, Osaka, Japan (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912524
Brehl, C., Grünberger, A., Probst, C., Pfaff, C., Wiechert, W., Behrendt, D., Kohlheyer, D.: Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments. Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912526
Westerwalbesloh, C., Grünberger, A., Wiechert, W., Kohlheyer, D., von Lieres, E.: Comparison of different cultivation chamber designs for microfluidic bioreactors. Chemie Ingenieur Technik. 88, 1390 (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912529
Grünberger, A., Steffens, I., Binder, D., Drepper, T., Wiechert, W., Kohlheyer, D.: Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion. Presented at the EMBL Conference Microfluidics, Heidelberg, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912531
Westerwalbesloh, C., Grünberger, A., Kohlheyer, D., von Lieres, E.: Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912536
Sachs, C.C., Probst, C., Grünberger, A., Wiechert, W., Frunzke, J., Kohlheyer, D., Nöh, K.: An integrated platform for dynamic microfluidic experimentation with single-cell resolution. Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912538
Steffens, I., Grünberger, A., Binder, D., Drepper, T., Wiechert, W., Kohlheyer, D.: Bacterial phase diagrams. Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany) (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912540
Grünberger, A., Steffens, I., Binder, D., Drepper, T., Wiechert, W., Kohlheyer, D.: Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression. Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany (2016).
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2016 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912552
Probst, C., Freier, C., Mahr, R., Grünberger, A., Helfrich, S., Wiechert, W., Nöh, K., Frunzke, J., Kohlheyer, D.: Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms. 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). p. 537-539. Curran Associates, Inc., Red Hook, NY (2016).
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912739
Li, S., Jendresen, C.B., Grünberger, A., Ronda, C., Jensen, S.I., Noack, S., Nielsen, A.T.: Enhanced protein and biochemical production using CRISPRi-based growth switches. Metabolic Engineering. 38, 274-284 (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912760
Grünberger, A.: Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level. Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912772
Grünberger, A., Sachs, C., Kohlheyer, D., Wiechert, W., Nöh, K.: Spatio-temporal analysis of bacterial populations at single-cell level. Presented at the IBG Modelling Workshop, Jülich, Germany (2016).
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912513
Kusen, P.M., Wandrey, G., Probst, C., Grünberger, A., Holz, M., Meyer zu Berstenhorst, S., Kohlheyer, D., Büchs, J., Pietruszka, J.: Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine. ACS chemical biology. 11, 2915-2922 (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912525
Burmeister, A., Bitzenhofer, N.L., Grünberger, A., Binder, D., Drepper, T., Wiechert, W.: Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level. Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912532
Westerwalbesloh, C., Grünberger, A., Stute, B., Weber, S., Kohlheyer, D., von Lieres, E.: Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells. Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912537
Grünberger, A., Wiechert, W., Kohlheyer, D.: Bioprocesses under magnification. Learning from single cells about large-scale processes. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany (2016).
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912544
Binder, D., Bier, C., Grünberger, A., Drobietz, D., Hage-Hülsmann, J., rey, G., Büchs, J., Kohlheyer, D., Loeschcke, A., Wiechert, W., Jaeger, K.-E., Pietruszka, J., Drepper, T.: Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression. ChemBioChem. 17, 296-299 (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912511
Bier, C., Binder, D., Grünberger, A., Drobietz, D., Kohlheyer, D., Löschcke, A., Jaeger, K.-E., Drepper, T., Pietruszka, J.: Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications. Presented at the 18th International Conference on Photochemistry, Paris, France (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912523
Brehl, C., Grünberger, A., Probst, C., Pfaff, C., Wiechert, W., Behrendt, D., Kohlheyer, D.: Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments. Presented at the ProcessNet 2016, Aachen, Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912530
Kaganovitch, E., Probst, C., Westerwalbesloh, C., Grünberger, A., Wiechert, W., Kohlheyer, D.: Single-cell analysis of E. coli in microfluidic batch reactors. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany (2016).
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912535
Grünberger, A., Steffens, I., Binder, D., Drepper, T., Wiechert, W., Kohlheyer, D.: Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression. Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany (2016).
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