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196 Publikationen

2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2919063
Visualization of tandem repeat mutagenesis in Bacillus subtilis
Dormeyer M, Lentes S, Ballin P, Wilkens M, Klumpp S, Kohlheyer D, Stannek L, Grünberger A, Commichau FM (2018)
DNA REPAIR 63: 10-15.
PUB | DOI | WoS | PubMed | Europe PMC
 
2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912738
Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2017)
Microbial Biotechnology 10(4): 845-857.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916519
Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity
Binder D, Drepper T, Jaeger K-E, Delvigne F, Wiechert W, Kohlheyer D, Grünberger A (2017)
METABOLIC ENGINEERING 42: 145-156.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912503
Picoliter bioreactors for microbial consortia: From proof of concept to first application
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912508
Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level
Burmeister A, Bitzenhofer NL, Grünberger A, Binder D, Drepper T, Wiechert W, Kohlheyer D (2017)
Presented at the BioProcessing Days 2017, Recklinghausen, Germany.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912771
Microfluidic single-cell (co-)cultivation: Exploring the next dimension
Rudat A, Noack S, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the Data-driven Biotechnology - bench, bioreactor and bedside, Copenhagen, Denmark.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912759
Microfluidic Single-Cell Cultivation: A key for next generation bioprocess development?
Grünberger A (2017)
Presented at the FFBiotech Symposium - Innovative approaches in bioreactors design and operation, Lille, France.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912505
Microfluidic single-cell cultivation of S. lividans: Uncovering heterogeneity in filamentous growth
Sachs CC, Koepff J, Kohlheyer D, Wiechert W, Oldiges M, Nöh K, Grünberger A (2017)
Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912502
Functionally-active protein aggregates - towards the realization of an enzyme cascade in catalytically-active inclusion bodies
Jäger VD, Longerich S, Dietrich M, Kloss R, Grünberger A, Pohl M, Jaeger K-E, Krauss U (2017)
Presented at the BioTrans 2017, Budapest, Hungary.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912507
Spatiotemporal analysis of synthetic microbial communities at the single-cell level in microfluidic interaction compartments
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the 6th International Conference on Microbial Communication for Young Scientists, Jena, Germany.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912521
Real-time monitoring of fungal growth and morphogenesis at single-cell resolution
Grünberger A, Schöler K, Probst C, Kornfeld G, Hardiman T, Wiechert W, Kohlheyer D, Noack S (2017)
Engineering in life sciences 17(1): 86–92.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912501
Catalytically active inclusion bodies. A novel carrier-free Enzyme Immobilisation method
Kloss R, Limberg M, Jäger VD, Mackfeld U, Karmainski T, Grünberger A, Krauss U, Pohl M (2017)
Presented at the BioTrans 2017, Budapest, Hungary.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912506
Integrated High-Throughput Platform for Microfluidic Live-Cell Analysis with Feed-Back Eyperimentation
Sachs CC, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2017)
Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
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2017 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912518
Microfluidic device for control and sensing of dynamic oxygen levels during cell cultivation
Kaganovitch E, Krischer M, Probst C, Grünberger A, Zunic E, Freier C, Wiechert W, Kohlheyer D (2017)
In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.: 355-356.
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2017 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2912520
Application of Mini- and Micro-Bioreactors for Microbial Bioprocesses
Ladner T, Grünberger A, Probst C, Kohlheyer D, Büchs J, Delvigne F (2017)
In: Current Developments in Biotechnology and Bioengineering. Larroche C, Sanromán MÁ, Du G, Pandey A (Eds); Amsterdam: Elsevier: 433-461.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912737
Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses
Delvigne F, Baert J, Sassi H, Fickers P, Grünberger A, Dusny C (2017)
Biotechnology Journal 12(7): 1600549.
PUB | DOI | WoS | PubMed | Europe PMC
 
2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912504
Models for Developing and Optimizing Microscale Bacteria Cultivation
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2017)
Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912509
Microfluidic cultivation chamber for the investigation of synthetic microbial co-cultures on single-cell level: From the development to first application
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the BioProcessing Days 2017, Recklinghausen, Germany.
PUB
 
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912522
Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments
Sachs CC, Grünberger A, Helfrich S, Probst C, Wiechert W, Kohlheyer D, Nöh K (2016)
PLoS one 11(9): e0163453 -.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912514
Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation
Binder D, Probst C, Grünberger A, Hilgers F, Loeschcke A, Jaeger K-E, Kohlheyer D, Drepper T (2016)
PLoS one 11(8): e0160711.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912820
Combinatorial antibiotic effects of natural biocide cocktails
Hage-Hülsmann J, Grünberger A, Thies S, Domröse A, Klein A, Binder D, Hilgers F, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T, et al. (2016)
Presented at the IV International Conference on Antimicrobial Research, Malaga, Spain.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912527
Microfluidic single-cell cultivation: Is small the new beautiful?
Grünberger A (2016)
Presented at the 6th International Bielefeld-CeBiTec Research Conference: Advances in Industrial Biotechnology: New Techniques, Substrates and Products for Bioprocesses, Bielefeld, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912534
Single-cell microfluidics for bioprocess development
Grünberger A (2016)
Presented at the GreenWin Conferences “Green Chemistry and White Biotechnology", Gembloux, Belgium.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912539
Nutrient distribution in perfusion based picoliter bioreactors
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E (2016)
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912803
Employing photocaged carbohydrates in light-controlled cell factories for synthetic bio(techno)logy and single cell applications
Binder D, Bier C, Grünberger A, Hilgers F, Loeschcke A, Kohlheyer D, Pietruszka J, Jaeger KE, Drepper T (2016)
Presented at the Annual Conference of the Association for General and Applied Microbiology (VAAM),, Jena, Germany.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912761
Microfluidic single-cell bioreactors. Introduction, application and future perspectives
Grünberger A (2016)
Presented at the LCSB Biannual Minisymposia in Modelling/Automation/Microfluidics at the University of Luxembourg, Esch-sur-Alzette, Luxembourg.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912512
Sugar Based Caged Compounds for Biotechnological Synthetic Biological Applications
Bier C, Binder D, Grünberger A, Drobietz D, Hage-Hülsmann J, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Presented at the 26th IUPAC Symposium on Photochemistry, Osaka, Japan.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912524
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912529
Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the EMBL Conference Microfluidics, Heidelberg, Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912531
Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices
Westerwalbesloh C, Grünberger A, Kohlheyer D, von Lieres E (2016)
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912536
An integrated platform for dynamic microfluidic experimentation with single-cell resolution
Sachs CC, Probst C, Grünberger A, Wiechert W, Frunzke J, Kohlheyer D, Nöh K (2016)
Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912526
Comparison of different cultivation chamber designs for microfluidic bioreactors
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2016)
Chemie Ingenieur Technik 88(9): 1390.
PUB | DOI
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912538
Bacterial phase diagrams. Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression
Steffens I, Grünberger A, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany).
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912540
Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany.
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2016 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912552
Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms
Probst C, Freier C, Mahr R, Grünberger A, Helfrich S, Wiechert W, Nöh K, Frunzke J, Kohlheyer D (2016)
In: 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Red Hook, NY: Curran Associates, Inc.: 537-539.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912513
Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine
Kusen PM, Wandrey G, Probst C, Grünberger A, Holz M, Meyer zu Berstenhorst S, Kohlheyer D, Büchs J, Pietruszka J (2016)
ACS chemical biology 11(10): 2915-2922.
PUB | DOI | WoS | PubMed | Europe PMC
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912525
Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level
Burmeister A, Bitzenhofer NL, Grünberger A, Binder D, Drepper T, Wiechert W (2016)
Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912532
Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Kohlheyer D, von Lieres E (2016)
Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912537
Bioprocesses under magnification. Learning from single cells about large-scale processes
Grünberger A, Wiechert W, Kohlheyer D (2016)
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
PUB
 
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912544
Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression
Binder D, Bier C, Grünberger A, Drobietz D, Hage-Hülsmann J, rey G, Büchs J, Kohlheyer D, Loeschcke A, Wiechert W, Jaeger K-E, et al. (2016)
ChemBioChem 17(4): 296-299.
PUB | DOI | WoS | PubMed | Europe PMC
 
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912739
Enhanced protein and biochemical production using CRISPRi-based growth switches
Li S, Jendresen CB, Grünberger A, Ronda C, Jensen SI, Noack S, Nielsen AT (2016)
Metabolic Engineering 38: 274-284.
PUB | DOI | WoS | PubMed | Europe PMC
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912760
Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level
Grünberger A (2016)
Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912772
Spatio-temporal analysis of bacterial populations at single-cell level
Grünberger A, Sachs C, Kohlheyer D, Wiechert W, Nöh K (2016)
Presented at the IBG Modelling Workshop, Jülich, Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912511
Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications
Bier C, Binder D, Grünberger A, Drobietz D, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Presented at the 18th International Conference on Photochemistry, Paris, France.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912523
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Presented at the ProcessNet 2016, Aachen, Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912530
Single-cell analysis of E. coli in microfluidic batch reactors
Kaganovitch E, Probst C, Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D (2016)
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
PUB
 
2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912535
Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany.
PUB
 
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904866
Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum
Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger K-E, et al. (2016)
Appl Environ Microbiol 82: 6141-6149.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912554
Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester
Krämer CEM, Singh A, Helfrich S, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2015)
PLoS one 10(10): e0141768.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912541
Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications
Binder D, Bier C, Grünberger A, Loeschcke A, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T (2015)
Presented at the ESP Photobiology conference, Aveiro, Portugal.
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