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200 Publikationen

2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912616
Unthan, Simon, Grünberger, Alexander, van Ooyen, Jan, Gätgens, Jochem, Heinrich, Johanna, Paczia, Nicole, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Noack, Stephan. “Beyond growth rate 0.6. What drives Corynebacterium glutamicum to higher growth rates in defined medium”. Biotechnology and bioengineering 111.2 (2014): 359–371.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912806
Binder, Dennis, Grünberger, Alexander, Loeschcke, Anita, Probst, Christopher, Bier, Claus, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jäger, Karl-Erich, and Drepper, Thomas. “Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers”. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany, 2014.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912730 OA
Nanda, Arun M., Heyer, Antonia, Kramer, Christina, Grünberger, Alexander, Kohlheyer, Dietrich, and Frunzke, Julia. “Analysis of SOS-Induced Spontaneous Prophage Induction in Corynebacterium glutamicum at the Single-Cell Level”. Journal of Bacteriology 196.1 (2014): 180-188.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912766
Grünberger, Alexander. “Picoliter Bioreactors. Learning from Single Cells about Large Scale Processes”. Presented at the iGEM Meetup, Aachen, Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912805
Kohlheyer, Dietrich, Grünberger, Alexander, Weber, S., Nedbal, Ladislav, and Wiechert, Wolfgang. “Microfluidic Single-Cell Analysis – Potential for Microalgae Research?”. Presented at the BioSC Workshop | Exploration "Perspectives of Algal Technologies", Jülich, Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912808
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. “Metabolite biosensors for single cell analysis and the development of production strains”. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912569
Binder, Dennis, Grünberger, Alexander, Loeschcke, Anita, Probst, Christopher, Bier, Claus, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jaeger, Karl-Erich, and Drepper, Thomas. “Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers”. Presented at the VAAM Jahrestagung, Dresden, Germany, 2014.
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2014 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912571
Grünberger, Alexander, Probst, Christopher, Helfrich, Stefan, Frunzke, Julia, Noack, Stephan, Nöh, Katharina, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Microfluidic Single-Cell Analysis Platform for Biotechnological Process Development”. MicroTAS 2014. San Diego, California: CBM Society, 2014. 3 p.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912576
Dusny, Christian, Grünberger, Alexander, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Schmid, Andreas. “From extracellular Environment to functional phenotype. Quantitative comparison of single cell physiology in static and steady environments”. Presented at the 3rd BioProScale Symposium "Inhomogeneities in large-scale bioprocesses. System biology and process dynamics", Berlin, Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912583
Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Picoliter Bioreactors. Learning from Single Cells about Large-Scale Bioprocesses”. Presented at the 24th Annual conference of the German Society for Cytometry, Dresden, Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912586
Helfrich, Stefan, Azzouzi, Charaf Eddine, Krämer, Christina, Pfeifer, Eugen, Grünberger, Alexander, Mustafi, Nurije, Wiechert, Wolfgang, Frunzke, Julia, Kohlheyer, Dietrich, and Nöh, Katharina. “Microbial Populations on the Microfluidic Analyst's Couch: Approaching Cellular Heterogeneity”. Presented at the BioImage Informatics 2014, Leuven, Belgium, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912588
Helfrich, Stefan, Grünberger, Alexander, Kohlheyer, Dietrich, Wiechert, Wolfgang, and Nöh, Katharina. “Investigating single-cell growth of microbial cell factories: is counting cells enough?”. Presented at the 2nd International Workshop on Image-based Systems Biology, Jena (Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912590
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. “Transcription factor-based biosensor for microbial strain development”. Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912593
Grünberger, Alexander, Unthan, Simon, Mahr, Regina, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Systematic screening of single-cell growth and production in a picoliter cultivation platform”. Chemie Ingenieur Technik 86.9 (2014): 1408.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912595
Kohlheyer, Dietrich, Grünberger, Alexander, Probst, Christopher, Helfrich, Stefan, Frunzke, Julia, Eggeling, Lothar, Nöh, Katharina, Noack, Stephan, and Wiechert, Wolfgang. “Single-cell Bioreactors boost Bioprocess Development: New Insights into Cellular Metabolism”. Presented at the Metabolic Engineering X, Vancouver, Canada, 2014.
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2014 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912601
Grünberger, Alexander, Schmitz, Katja, Probst, Christopher, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Simple microfluidics for complex organisms: A microfluidic chip System for growth and Morphogenesis studies of filamentous fungi”. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). Red Hook, NY: Curran, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912575
Krämer, Christina, Helfrich, Stefan, Azzouzi, Charaf Eddine, Grünberger, Alexander, Pfeifer, Eugen, Frunzke, Julia, Wiechert, Wolfgang, Nöh, Katharina, and Kohlheyer, Dietrich. “Microfluidics as platform for the spatiotemporal analysis of bacterial populations at single-cell level”. Presented at the International Meeting, Phenotypic heterogeneity and sociobiology of bacterial populations, Irsee, Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912582
Grünberger, Alexander, Probst, Christopher, Nanda, Arun, Frunzke, Julia, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Microfluidic Single-Cell Cultivation Systems: Versatile Tools for Microbiology”. Presented at the 4th Annual Conference of the Association for General and Applied Microbiology, Dresden, Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912587
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. “Metabolite biosensors for single cell analysis and the development of production strains”. Presented at the Gemeinsame Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie und der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Dresden, Germany, 2014.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912594 OA
Binder, Dennis, Grünberger, Alexander, Loeschcke, Anita, Probst, Christopher, Bier, Claus, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jaeger, Karl-Erich, and Drepper, Thomas. “Light-responsive control of bacterial gene Expression: precise triggering of the lac promoter activity using photocaged IPTG”. Integrative biology 6.8 (2014): 755-765.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912823
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. “Application of a genetically-encoded metabolite sensor for single cell analysis and development of production strains”. Presented at the Metabolic engineering X, Vancouver, Canada, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912814
Grünberger, Alexander, and Probst, Christopher. “Introduction into Microfluidic Single-Cell Analysis”. Presented at the Biology feat, Engineering – SYNBIO – Single Cell Analysis in Microfluidic Devices (Workshop), Jülich, Germany, 2014.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912605
Schendzielorz, Georg, Dippong, Martin, Grünberger, Alexander, Kohlheyer, Dietrich, Yoshida, Ayako, Binder, Stephan, Nishiyama, Chiharu, Nishiyama, Makoto, Bott, Michael, and Eggeling, Lothar. “Taking Control over Control: Use of Product Sensing in Single Cells to Remove Flux Control at Key Enzymes in Biosynthesis Pathways”. ACS Synthetic Biology 3.1 (2014): 21–29.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912573 OA
Mustafi, Nurije, Grünberger, Alexander, Mahr, Regina, Helfrich, Stefan, Nöh, Katharina, Blombach, Bastian, Kohlheyer, Dietrich, and Frunzke, Julia. “Application of a Genetically Encoded Biosensor for Live Cell Imaging of L-Valine Production in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains”. PLoS one 9.1 (2014): e85731.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912580
Dusny, Christian, Grünberger, Alexander, Rosenthal, Katrin, Wiechert, Wolfgang, and Schmid, Andreas. “Quantitative Physiology of Single Cells for Linking Phenotype and Environment”. Presented at the 24th Annual Conference of the German Society for Flow Cytometry, Dresden, Germany, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912585
Sachs, Christian Carsten, Grünberger, Alexander, Wiechert, Wolfgang, Nöh, Katharina, and Kohlheyer, Dietrich. “Robust Automated Image Analysis of Mother Machine Microfluidic Growth Devices”. Presented at the BioImage Informatics 2014, Leuven, Belgium, 2014.
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2014 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912592
Weber, Sophie, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Optimizing growth performance of Corynebacterium glutamicum at the single-cell level”. Chemie Ingenieur Technik 88.9 (2014): 1414.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912597
Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Single-cell microfluidics: opportunity for bioprocess development”. Current opinion in biotechnology 29 (2014): 15-23.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912604
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. “Application of a genetically encoded biosensor for single cell analysis and strain development of production strains”. Presented at the New concepts and approaches in microbiology, Heidelberg, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912609
Nanda, Arun, Heyer, Antonia, Grünberger, Alexander, Helfrich, Stefan, Kohlheyer, Dietrich, Nöh, Katharina, and Frunzke, Julia. “Single-cell Dynamics of the SOS Response in Corynebacterium glutamicum”. Presented at the Bacterial Networks, Pultusk, Poland, 2013.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912611 OA
Probst, Christopher, Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Polydimethylsiloxane (PDMS) Sub-Micron Traps for Single-Cell Analysis of Bacteria”. Micromachines 4.4 (2013): 357-369.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912623
Heyer, Antonia, Nanda, Arun, Grünberger, Alexander, Kohlheyer, Dietrich, and Frunzke, Julia. “Spontaneous prophage induction in Corynebacterium glutamicum”. Presented at the VAAM-Tagung 2013, Bremen, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912630
Kohlheyer, Dietrich, Grünberger, Alexander, Probst, Christopher, Krämer, Christina, Eggeling, Lothar., Frunzke, Julia, and Wiechert, Wolfgang. “Microbial single cell analysis of production strains in microfabricated habitats”. Presented at the DECHEMA-Workshop Microfluidics for Systems Biology and Bioprocess Development, Frankfurt, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912825
Binder, D., Grünberger, Alexander, Loeschcke, A., Probst, Christopher, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jaeger, Karl Erich, and Drepper, T. “Characterization of light-triggered gene expression in E. coli with respect to population and single cell response”. Presented at the Jülich Biotech Day, Jülich, Germany, 2013.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912745
Grünberger, Alexander, Lai, Pin-Kuang, Blanco, Marco A., and Roberts, Christopher J. “Coarse-Grained Modeling of Protein Second Osmotic Virial Coefficients: Sterics and Short-Ranged Attractions”. The Journal of Physical Chemistry B 117.3 (2013): 763-770.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912810
Helfrich, Stefan, Grünberger, Alexander, Kohlheyer, Dietrich, Wiechert, Wolfgang, and Nöh, Katharina. “Analysis of microbial observables on single cell level: Challenges of Cell Clusters for Microscopy-based Image Processing”. Presented at the 9th European Congress of Chemical Engineering (ECCE9)/ 2nd European Congress of Applied Biotechnology (ECAB2), The Hague, Netherlands, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912824
Nanda, Arun M., Heyer, Antonia, Grünberger, Alexander, Helfrich, Stefan, Kohlheyer, Dietrich, Nöh, Katharina, and Frunzke, Juia. “Single-cell dynamics of the SOS response in Corynebacterium glutamicum”. Presented at the Jülich Biotech Day, Jülich, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912827
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. “Application of a genetically- encoded metabolite sensor for single cell analysis and the development of production strains”. Presented at the Jülich Biotech Day, Jülich, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912829
Sachs, Christian, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Automated image analysis pipeline for single cell bacterial growth studies”. Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912834
Binder, D., Grünberger, Alexander, Loeschcke, A., Probst, Christopher, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jaeger, Karl Erich, and Drepper, T. “Characterization of light-triggered gene expression in E. coli with respect to population and single cell response”. Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912836
Binder, D., Grünberger, Alexander, Loeschcke, A., Probst, Christopher, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jaeger, Karl Erich, and Drepper, T. “Characterization of light-triggered gene expression in E. coli with respect to population and single cell response”. Presented at the New Approaches and Concepts in Microbiology, Heidelberg, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912603
Grünberger, Alexander, Probst, Christopher, Unthan, Simon, Krämer, Christina, Paczia, Nicole, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Single Cell Bioreactors for Bioprocess Optimization”. Presented at the Jülich Biotech Day 2013, Jülich,Germany, 2013.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912606
Hoffmann, Kristina, Grünberger, Alexander, Lausberg, Frank, Bott, Michael, and Eggeling, Lothar. “Visualization of Imbalances in Sulfur Assimilation and Synthesis of Sulfur-Containing Amino Acids at the Single-Cell Level”. Applied and environmental microbiology 79.21 (2013): 6730-6736.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912608
Nanda, Arun, Heyer, Antonia, Krämer, Christina, Grünberger, Alexander, Kohlheyer, Dietrich, and Frunzke, Julia. “SOS-induced spontaneous prophage induction in Corynebacterium glutamicum”. Presented at the Jülich Biotech Day 2013, Jülich, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912613
Probst, Christopher, Grünberger, Alexander, Frunzke, Julia, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Microfluidic cultivation technology and application: analysing single-microbes under perfect environmental control”. Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912615
Helfrich, Stefan, Azzouzi, Charaf Eddine, Grünberger, Alexander, Wiechert, Wolfgang, and Nöh, Katharina. “Explorative Analysis of Cell Population Development: Customizable Interactive Lineage Trees”. Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912618
Kohlheyer, Dietrich, Grünberger, Alexander, Probst, Christopher, Frunzke, Julia, and Wiechert, Wolfgang. “Picoliter fermentation with single bacteria: Learning from the one to unravel the crowd”. Presented at the 2nd International Congress Implementation of Microreactor Technology in Biotechnology, Cavtat, Croatia, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912620
Noack, Stephan, Grünberger, Alexander, van Ooyen, Jan, Kohlheyer, Dietrich, and Wiechert, Wolfgang. “Increasing biomass productivity of C. glutamicum - new insights from microscale cultivations”. Presented at the 9th European Congress of Chemical Engineering, Den Haag, The Netherlands, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912622
Wiechert, Wolfgang, Kohlheyer, Dietrich, Noack, Stephan, Frunzke, Julia, Mustafi, Nurije, and Grünberger, Alexander. “Picoliter Bioreactors. Learning from Single Cells about Large Scale Processes”. Presented at the Copenhagen Bioscience Conferences, Cell Factories and Biosustainability, Favrholm, Denmark, 2013.
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2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912625
Heinrich, Johanna, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Single cell growth under constant environmental conditions and defined C sources: A case study for Corynebacterium glutamicum”. Presented at the VAAM-Tagung 2013, Bremen, Germany, 2013.
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