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196 Publikationen

2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936034
Lindemann, Dorina, Westerwalbesloh, Christoph, Kohlheyer, Dietrich, Grünberger, Alexander, and von Lieres, Eric. “Microbial single-cell growth response at defined carbon limiting conditions”. RSC ADVANCES 9.25 (2019): 14040-14050.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2935496
Westerwalbesloh, Christoph, Brehl, Carl, Weber, Sophie, Probst, Christopher, Widzgowski, Janka, Grünberger, Alexander, Pfaff, Christian, Nedbal, Ladislav, and Kohlheyer, Dietrich. “A microfluidic photobioreactor for simultaneous observation and cultivation of single microalgal cells or cell aggregates.”. PloS one 14.4 (2019).
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2933358
Schmitz, Julian, Noll, Thomas, and Grünberger, Alexander. “Heterogeneity Studies of Mammalian Cells for Bioproduction. From Tools to Application”. Trends in Biotechnology (2019).
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2935887
Sassi, Hosni, Nguyen, Thai Minh, Telek, Samuel, Gosset, Guillermo, Grünberger, Alexander, and Delvigne, Frank. “Segregostat: a novel concept to control phenotypic diversification dynamics on the example of Gram-negative bacteria.”. Microbial biotechnology (2019).
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2935495
Ho, Phuong, Westerwalbesloh, Christoph, Kaganovitch, Eugen, Grünberger, Alexander, Neubauer, Peter, Kohlheyer, Dietrich, and Lieres, Eric von. “Reproduction of Large-Scale Bioreactor Conditions on Microfluidic Chips.”. Microorganisms 7.4 (2019).
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2935584
Theorell, Axel, Seiffarth, Johannes, Grünberger, Alexander, and Noeh, Katharina. “When a single lineage is not enough: Uncertainty-Aware Tracking for spatio-temporal live-cell image analysis”. BIOINFORMATICS 35.7 (2019): 1221-1228.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934065
Jager, V D, Kloss, R, Grünberger, Alexander, Seide, S, Hahn, D, Karmainski, T, Piqueray, M, Embruch, J, Longerich, S, Mackfeld, U, Jaeger, K-E, Wiechert, W, Pohl, M, and Krauss, U. “Tailoring the properties of (catalytically)-active inclusion bodies.”. Microbial cell factories 18.1 (2019).
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932955
Burmeister, Alina, Hilgers, Fabienne, Langner, Annika, Westerwalbesloh, Christoph, Kerkhoff, Yannic, Tenhaef, Niklas, Drepper, Thomas, Kohlheyer, Dietrich, von Lieres, Eric, Noack, Stephan, and Grünberger, Alexander. “A microfluidic co-cultivation platform to investigate microbial interactions at defined microenvironments”. LAB ON A CHIP 19.1 (2019): 98-110.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2919078
Hornung, Raphael, Grünberger, Alexander, Westerwalbesloh, Christoph, Kohlheyer, Dietrich, Gompper, Gerhard, and Elgeti, Jens. “Quantitative modelling of nutrient-limited growth of bacterial colonies in microfluidic cultivation”. JOURNAL OF THE ROYAL SOCIETY INTERFACE 15.139 (2018): 11.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932764
Koepff, Joachim, Sachs, Christian Carsten, Wiechert, Wolfgang, Kohlheyer, Dietrich, Noeh, Katharina, Oldiges, Marco, and Grünberger, Alexander. “Germination and Growth Analysis of Streptomyces lividans at the Single-Cell Level Under Varying Medium Compositions”. FRONTIERS IN MICROBIOLOGY 9 (2018): 2680.
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2018 | Konferenzbeitrag | PUB-ID: 2933363
Schmitz, Julian, Noll, Thomas, and Grünberger, Alexander. “Towards Microfluidic Single-Cell Cultivation of Mammalian Cell Lines”. Presented at the Young Scientist Cell Culture Biotechnology Retreat, Laupheim, 2018.
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2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933359
Schmitz, Julian, Kerkhoff, Yannic, Noll, Thomas, Kohlheyer, Dietrich, and Grünberger, Alexander. “Towards dynamic single-cell cultivation systems for industrially relevant mammalian cell lines”. Presented at the BioProcessing Days 2018, Recklinghausen, 2018.
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2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933362
Schmitz, Julian, Kerkhoff, Yannic, Noll, Thomas, and Grünberger, Alexander. “Dynamic microfluidical single-cell cultivation of mammalian cell lines. From experiment to analysis”. Presented at the CeBiTec Symposium 2018, Bielefeld, 2018.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932765
Kloss, Ramona, Karmainski, Tobias, Jaeger, Vera D., Hahn, Doris, Grünberger, Alexander, Baumgart, Meike, Krauss, Ulrich, Jaeger, Karl-Erich, Wiechert, Wolfgang, and Pohl, Martina. “Tailor-made catalytically active inclusion bodies for different applications in biocatalysis”. CATALYSIS SCIENCE & TECHNOLOGY 8.22 (2018): 5816-5826.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932416
Kampf, Jan, Gerwig, Jan, Kruse, Kerstin, Cleverley, Robert, Dormeyer, Miriam, Grünberger, Alexander, Kohlheyer, Dietrich, Commichau, Fabian M., Lewis, Richard J., and Stuelke, Joerg. “Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability”. mBio 9.5 (2018): e01464-18.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2930515
Hage-Huelsmann, Jennifer, Grünberger, Alexander, Thies, Stephan, Santiago-Schuebel, Beatrix, Klein, Andreas Sebastian, Pietruszka, Joerg, Binder, Dennis, Hilgers, Fabienne, Domroese, Andreas, Drepper, Thomas, Kohlheyer, Dietrich, Jaeger, Karl-Erich, and Loeschcke, Anita. “Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants”. PLOS ONE 13.7 (2018): e0200940.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920273
Kloss, Ramona, Limberg, Michael H., Mackfeld, Ursula, Hahn, Doris, Grünberger, Alexander, Jaeger, Vera D., Krauss, Ulrich, Oldiges, Marco, and Pohl, Martina. “Catalytically active inclusion bodies of L-lysine decarboxylase from E. coli for 1,5-diaminopentane production”. SCIENTIFIC REPORTS 8 (2018): 11.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920685
Mosheiff, Noga, Martins, Bruno M. C., Pearl-Mizrahi, Sivan, Grünberger, Alexander, Helfrich, Stefan, Mihalcescu, Irina, Kohlheyer, Dietrich, Locke, James C. W., Glass, Leon, and Balaban, Nathalie Q. “Inheritance of Cell-Cycle Duration in the Presence of Periodic Forcing”. PHYSICAL REVIEW X 8.2 (2018): 15.
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2018 | Bielefelder E-Dissertation | PUB-ID: 2919683
Radek, Andreas. Establishing the Weimberg pathway in Corynebacterium glutamicum as an alternative route for D-xylose utilization. Bielefeld: Universität Bielefeld, 2018.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2931505
Jaeger, Vera D., Lamm, Robin, Kloss, Ramona, Kaganovitch, Eugen, Grünberger, Alexander, Pohl, Martina, Buechs, Jochen, Jaeger, Karl-Erich, and Krauss, Ulrich. “A Synthetic Reaction Cascade Implemented by Colocalization of Two Proteins within Catalytically Active Inclusion Bodies”. ACS SYNTHETIC BIOLOGY 7.9 (2018): 2282-2295.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2919063
Dormeyer, Miriam, Lentes, Sabine, Ballin, Patrick, Wilkens, Markus, Klumpp, Stefan, Kohlheyer, Dietrich, Stannek, Lorena, Grünberger, Alexander, and Commichau, Fabian M. “Visualization of tandem repeat mutagenesis in Bacillus subtilis”. DNA REPAIR 63 (2018): 10-15.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912738
Westerwalbesloh, Christoph, Grünberger, Alexander, Wiechert, Wolfgang, Kohlheyer, Dietrich, and von Lieres, Eric. “Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level”. Microbial Biotechnology 10.4 (2017): 845-857.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916519
Binder, Dennis, Drepper, Thomas, Jaeger, Karl-Erich, Delvigne, Frank, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Grünberger, Alexander. “Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity”. METABOLIC ENGINEERING 42 (2017): 145-156.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912503
Rudat, Annika, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Grünberger, Alexander. “Picoliter bioreactors for microbial consortia: From proof of concept to first application”. Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany, 2017.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912508
Burmeister, Alina, Bitzenhofer, N. L., Grünberger, Alexander, Binder, Dennis, Drepper, Thomas, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level”. Presented at the BioProcessing Days 2017, Recklinghausen, Germany, 2017.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912771
Rudat, A., Noack, Stephan, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Grünberger, Alexander. “Microfluidic single-cell (co-)cultivation: Exploring the next dimension”. Presented at the Data-driven Biotechnology - bench, bioreactor and bedside, Copenhagen, Denmark, 2017.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912759
Grünberger, Alexander. “Microfluidic Single-Cell Cultivation: A key for next generation bioprocess development?”. Presented at the FFBiotech Symposium - Innovative approaches in bioreactors design and operation, Lille, France, 2017.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912505
Sachs, Christian Carsten, Koepff, Joachim, Kohlheyer, Dietrich, Wiechert, Wolfgang, Oldiges, Marco, Nöh, Katharina, and Grünberger, Alexander. “Microfluidic single-cell cultivation of S. lividans: Uncovering heterogeneity in filamentous growth”. Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany, 2017.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912502
Jäger, Vera D., Longerich, S., Dietrich, M., Kloss, Ramona, Grünberger, Alexander, Pohl, Martina, Jaeger, Karl-Erich, and Krauss, Ulrich. “Functionally-active protein aggregates - towards the realization of an enzyme cascade in catalytically-active inclusion bodies”. Presented at the BioTrans 2017, Budapest, Hungary, 2017.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912507
Rudat, Annika, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Grünberger, Alexander. “Spatiotemporal analysis of synthetic microbial communities at the single-cell level in microfluidic interaction compartments”. Presented at the 6th International Conference on Microbial Communication for Young Scientists, Jena, Germany, 2017.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912521
Grünberger, Alexander, Schöler, Katja, Probst, Christopher, Kornfeld, Georg, Hardiman, Timo, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Noack, Stephan. “Real-time monitoring of fungal growth and morphogenesis at single-cell resolution”. Engineering in life sciences 17.1 (2017): 86–92.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912501
Kloss, Ramona, Limberg, Michael, Jäger, Vera D., Mackfeld, Ursula, Karmainski, Tobias, Grünberger, Alexander, Krauss, Ulrich, and Pohl, Martina. “Catalytically active inclusion bodies. A novel carrier-free Enzyme Immobilisation method”. Presented at the BioTrans 2017, Budapest, Hungary, 2017.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912506
Sachs, Christian Carsten, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. “Integrated High-Throughput Platform for Microfluidic Live-Cell Analysis with Feed-Back Eyperimentation”. Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany, 2017.
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2017 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912518
Kaganovitch, Eugen, Krischer, Maximilian, Probst, Christopher, Grünberger, Alexander, Zunic, Ena, Freier, Christian, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Microfluidic device for control and sensing of dynamic oxygen levels during cell cultivation”. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc., 2017. 355-356.
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2017 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2912520
Ladner, T., Grünberger, Alexander, Probst, C., Kohlheyer, D., Büchs, J., and Delvigne, F. “Application of Mini- and Micro-Bioreactors for Microbial Bioprocesses”. Current Developments in Biotechnology and Bioengineering. Ed. Christian Larroche, Maria Ángeles Sanromán, Guocheng Du, and Ashok Pandey. Amsterdam: Elsevier, 2017. 433-461.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912737
Delvigne, Frank, Baert, Jonathan, Sassi, Hosni, Fickers, Patrick, Grünberger, Alexander, and Dusny, Christian. “Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses”. Biotechnology Journal 12.7 (2017): 1600549.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912504
Westerwalbesloh, Christoph, Grünberger, Alexander, Wiechert, Wolfgang, Kohlheyer, Dietrich, and von Lieres, Eric. “Models for Developing and Optimizing Microscale Bacteria Cultivation”. Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany, 2017.
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2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912509
Rudat, Annika, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Grünberger, Alexander. “Microfluidic cultivation chamber for the investigation of synthetic microbial co-cultures on single-cell level: From the development to first application”. Presented at the BioProcessing Days 2017, Recklinghausen, Germany, 2017.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912522
Sachs, Christian Carsten, Grünberger, Alexander, Helfrich, Stefan, Probst, Christopher, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. “Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments”. PLoS one 11.9 (2016): e0163453 -.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912514
Binder, Dennis, Probst, Christopher, Grünberger, Alexander, Hilgers, Fabienne, Loeschcke, Anita, Jaeger, Karl-Erich, Kohlheyer, Dietrich, and Drepper, Thomas. “Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation”. PLoS one 11.8 (2016): e0160711.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912820
Hage-Hülsmann, Jenny, Grünberger, Alexander, Thies, Stephan, Domröse, Andreas, Klein, Andreas, Binder, Dennis, Hilgers, Fabienne, Kohlheyer, Dietrich, Pietruszka, Jörg, Jaeger, Karl- Erich, Drepper, Thomas, and Loeschcke, Anita. “Combinatorial antibiotic effects of natural biocide cocktails”. Presented at the IV International Conference on Antimicrobial Research, Malaga, Spain, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912527
Grünberger, Alexander. “Microfluidic single-cell cultivation: Is small the new beautiful?”. Presented at the 6th International Bielefeld-CeBiTec Research Conference: Advances in Industrial Biotechnology: New Techniques, Substrates and Products for Bioprocesses, Bielefeld, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912534
Grünberger, Alexander. “Single-cell microfluidics for bioprocess development”. Presented at the GreenWin Conferences “Green Chemistry and White Biotechnology", Gembloux, Belgium, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912539
Westerwalbesloh, Christoph, Grünberger, Alexander, Stute, Birgit, Weber, Sophie, Wiechert, Wolfgang, Kohlheyer, Dietrich, and von Lieres, Eric. “Nutrient distribution in perfusion based picoliter bioreactors”. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912803
Binder, Dennis, Bier, Claus, Grünberger, Alexander, Hilgers, F., Loeschcke, Anita, Kohlheyer, Dietrich, Pietruszka, Jörg, Jaeger, Karl Erich, and Drepper, Thomas. “Employing photocaged carbohydrates in light-controlled cell factories for synthetic bio(techno)logy and single cell applications”. Presented at the Annual Conference of the Association for General and Applied Microbiology (VAAM),, Jena, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912761
Grünberger, Alexander. “Microfluidic single-cell bioreactors. Introduction, application and future perspectives”. Presented at the LCSB Biannual Minisymposia in Modelling/Automation/Microfluidics at the University of Luxembourg, Esch-sur-Alzette, Luxembourg, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912512
Bier, Claus, Binder, Dennis, Grünberger, Alexander, Drobietz, Dagmar, Hage-Hülsmann, Jennifer, Kohlheyer, Dietrich, Löschcke, Anita, Jaeger, Karl-Erich, Drepper, Thomas, and Pietruszka, Jörg. “Sugar Based Caged Compounds for Biotechnological Synthetic Biological Applications”. Presented at the 26th IUPAC Symposium on Photochemistry, Osaka, Japan, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912524
Brehl, Carl, Grünberger, Alexander, Probst, Christopher, Pfaff, Christian, Wiechert, Wolfgang, Behrendt, Dominik, and Kohlheyer, Dietrich. “Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments”. Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912529
Grünberger, Alexander, Steffens, Iska, Binder, Dennis, Drepper, Thomas, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion”. Presented at the EMBL Conference Microfluidics, Heidelberg, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912531
Westerwalbesloh, Christoph, Grünberger, Alexander, Kohlheyer, Dietrich, and von Lieres, Eric. “Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices”. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912536
Sachs, Christian Carsten, Probst, Christopher, Grünberger, Alexander, Wiechert, Wolfgang, Frunzke, Julia, Kohlheyer, Dietrich, and Nöh, Katharina. “An integrated platform for dynamic microfluidic experimentation with single-cell resolution”. Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912526
Westerwalbesloh, Christoph, Grünberger, Alexander, Wiechert, Wolfgang, Kohlheyer, Dietrich, and von Lieres, Eric. “Comparison of different cultivation chamber designs for microfluidic bioreactors”. Chemie Ingenieur Technik 88.9 (2016): 1390.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912538
Steffens, Iska, Grünberger, Alexander, Binder, Dennis, Drepper, Thomas, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Bacterial phase diagrams. Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression”. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany), 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912540
Grünberger, Alexander, Steffens, Iska, Binder, Dennis, Drepper, Thomas, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression”. Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany, 2016.
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2016 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912552
Probst, Christopher, Freier, Christian, Mahr, Regina, Grünberger, Alexander, Helfrich, Stefan, Wiechert, Wolfgang, Nöh, Katharina, Frunzke, Julia, and Kohlheyer, Dietrich. “Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms”. 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Red Hook, NY: Curran Associates, Inc., 2016. 537-539.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912513
Kusen, Peter M., Wandrey, Georg, Probst, Christopher, Grünberger, Alexander, Holz, Martina, Meyer zu Berstenhorst, Sonja, Kohlheyer, Dietrich, Büchs, Jochen, and Pietruszka, Jörg. “Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine”. ACS chemical biology 11.10 (2016): 2915-2922.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912525
Burmeister, Alina, Bitzenhofer, N. L., Grünberger, Alexander, Binder, Dennis, Drepper, Thomas, and Wiechert, Wolfgang. “Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level”. Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912532
Westerwalbesloh, Christoph, Grünberger, Alexander, Stute, Birgit, Weber, Sophie, Kohlheyer, Dietrich, and von Lieres, Eric. “Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells”. Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912537
Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Bioprocesses under magnification. Learning from single cells about large-scale processes”. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany, 2016.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912544
Binder, Dennis, Bier, Claus, Grünberger, Alexander, Drobietz, Dagmar, Hage-Hülsmann, Jennifer, rey, Georg, Büchs, Jochen, Kohlheyer, Dietrich, Loeschcke, Anita, Wiechert, Wolfgang, Jaeger, Karl-Erich, Pietruszka, Jörg, and Drepper, Thomas. “Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression”. ChemBioChem 17.4 (2016): 296-299.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912739
Li, Songyuan, Jendresen, Christian Bille, Grünberger, Alexander, Ronda, Carlotta, Jensen, Sheila Ingemann, Noack, Stephan, and Nielsen, Alex Toftgaard. “Enhanced protein and biochemical production using CRISPRi-based growth switches”. Metabolic Engineering 38 (2016): 274-284.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912760
Grünberger, Alexander. “Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level”. Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912772
Grünberger, Alexander, Sachs, Christian, Kohlheyer, Dietrich, Wiechert, Wolfgang, and Nöh, Katharina. “Spatio-temporal analysis of bacterial populations at single-cell level”. Presented at the IBG Modelling Workshop, Jülich, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912511
Bier, Claus, Binder, Dennis, Grünberger, Alexander, Drobietz, Dagmar, Kohlheyer, Dietrich, Löschcke, Anita, Jaeger, Karl-Erich, Drepper, Thomas, and Pietruszka, Jörg. “Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications”. Presented at the 18th International Conference on Photochemistry, Paris, France, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912523
Brehl, Carl, Grünberger, Alexander, Probst, Christopher, Pfaff, Christian, Wiechert, Wolfgang, Behrendt, Dominik, and Kohlheyer, Dietrich. “Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments”. Presented at the ProcessNet 2016, Aachen, Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912530
Kaganovitch, Eugen, Probst, Christopher, Westerwalbesloh, Christoph, Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Single-cell analysis of E. coli in microfluidic batch reactors”. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany, 2016.
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912535
Grünberger, Alexander, Steffens, Iska, Binder, Dennis, Drepper, Thomas, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression”. Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany, 2016.
PUB
 
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904866
Binder, Dennis, Frohwitter, Jonas, Mahr, Regina, Bier, Claus, Grünberger, Alexander, Loeschcke, Anita, Peters-Wendisch, Petra, Kohlheyer, Dietrich, Pietruszka, Jörg, Frunzke, Julia, Jaeger, Karl-Erich, Wendisch, Volker F., and Drepper, Thomas. “Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum”. Appl Environ Microbiol 82 (2016): 6141-6149.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912554
Krämer, Christina E. M., Singh, Abhijeet, Helfrich, Stefan, Grünberger, Alexander, Wiechert, Wolfgang, Nöh, Katharina, and Kohlheyer, Dietrich. “Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester”. PLoS one 10.10 (2015): e0141768.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912541
Binder, Dennis, Bier, Claus, Grünberger, Alexander, Loeschcke, Anita, Kohlheyer, Dietrich, Pietruszka, Jörg, Jaeger, Karl-Erich, and Drepper, Thomas. “Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications”. Presented at the ESP Photobiology conference, Aveiro, Portugal, 2015.
PUB
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912546
Grünberger, Alexander, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Single-cell microfluidics: A key technology to understand life at environmental defined conditions”. Presented at the Kick-off Konferenz: Leben? - Eine neue Förderinitiative stellt sich vor, Hannover, Germany, 2015.
PUB
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912560
Zunic, Ena, Schechtel, Anna, Probst, Christopher, Grünberger, Alexander, Freier, Christian, Seibold, Gerd, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Dynamic environmental control in microfluidic devices for single-cell Analysis of biological production processes”. Presented at the Kolloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany, 2015.
PUB
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912565
Grünberger, Alexander, Probst, Christopher, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Single-cell microfluidics meets applied biotechnology. From expectation to application”. Presented at the Conference "Cell Factories and Biosustainability - Technologies for Cell Factory Construction", Hillerod, Denmark, 2015.
PUB
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912584
Probst, Christopher, Grünberger, Alexander, Braun, Nadja, Helfrich, Stefan, Nöh, Katharina, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Rapid inoculation of single bacteria into parallel picoliter fermentation chambers”. Analytical methods 7.1 (2015): 91-98.
PUB | DOI | WoS
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912773
Grünberger, Alexander, Probst, Christopher, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Single-cell microfluidics meets applied biotechnology. From expectation to application”. Presented at the Jahreskongress Biotechnologie 2020+, Berlin, Germany, 2015.
PUB
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912548
Bier, Claus, Binder, Dennis, Grünberger, Alexander, Drobietz, Dagmar, Hage-Hülsmann, Jennifer, Kohlheyer, Dietrich, Loeschke, Anita, Jaeger, Karl-Erich, Drepper, Thomas, and Pietruszka, Jörg. “Caged Compounds for Biotechnological and Synthetic Biological Applications”. Presented at the European Society for Photobiology 2015 Congress, Aveiro, Portugal, 2015.
PUB
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912550
Grünberger, Alexander, Probst, Christopher, Helfrich, Stefan, Nanda, Arun, Stute, Birgit, Wiechert, Wolfgang, von Lieres, Eric, Nöh, Katharina, Frunzke, Julia, and Kohlheyer, Dietrich. “Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform”. Cytometry / A 87.12 (2015): 1101–1115.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912555
Helfrich, Stefan, Azzouzi, Charaf E., Probst, Christopher, Seiffarth, Johannes, Grünberger, Alexander, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. “Vizardous: interactive analysis of microbial populations with single cell resolution”. Bioinformatics 31.23 (2015): 3875-3877.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912562
Grünberger, Alexander. “Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar”. Biospektrum 21.3 (2015): 353-353.
PUB | DOI
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912567
Grünberger, Alexander. “Single-cell bioreactors: Improving the understanding of microbial metabolism”. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany, 2015.
PUB
 
2015 | Dissertation | Veröffentlicht | PUB-ID: 2912574
Grünberger, Alexander. Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors. Jülich: RWTH Aachen, 2015. Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies. 114.
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2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912545
Loeschcke, Anita, Thies, Stephan, Hage-Hülsmann, Jennifer, Grünberger, Alexander, Binder, Dennis, Domröse, Andreas, Klein, Andreas, Kohlheyer, Dietrich, Pietruszka, Jörg, Jaeger, Karl-Erich, and Drepper, Thomas. “Heterologous production of antibacterial secondary metabolites from Serratia marcescens in Pseudomonas putida”. Presented at the 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands, 2015.
PUB
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912557
Westerwalbesloh, Christoph, Grünberger, Alexander, Stute, Birgit, Weber, Sophie, Wiechert, Wolfgang, Kohlheyer, Dietrich, and von Lieres, Eric. “Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level”. Lab on a chip 15.21 (2015): 4177-4186.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912549
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. “Metabolite biosensors for single cell Analysis and the Evolution of production strains”. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany, 2015.
PUB
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912551
Probst, Christopher, Grünberger, Alexander, Krämer, Christina, Sachs, Christian Carsten, Wiechert, Wolfgang, Baumgart, Meike, and Kohlheyer, Dietrich. “Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging”. Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany, 2015.
PUB
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912556
Binder, Dennis, Probst, Christopher, Bier, Claus, Loeschcke, Anita, and Grünberger, Alexander. “Lichtgesteuerte Genexpression auf Einzelzellebene”. Biospektrum 21.6 (2015): 612-615.
PUB | DOI
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912563
Sachs, Christian Carsten, Helfrich, Stefan, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. “High-throughput, long-term growth characterization of C. glutamicum on single cell level using the Mother Machine”. Presented at the 3rd International Conference of the Cluster of Excellence Tailor-Made Fuels from Biomass, Aachen, Germany, 2015.
PUB
 
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912568
Dusny, Christian, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Schmid, Andreas. “Technical bias of microcultivation environments on single cell physiology”. Lab on a chip 15.8 (2015): 1822-1834.
PUB | DOI | WoS | PubMed | Europe PMC
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912804
Krämer, Christina, Helfrich, Stefan, Singh, Abhijeet, Grünberger, Alexander, Wiechert, Wolfgang, Nöh, Katharina, and Kohlheyer, Dietrich. “Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants”. Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia, 2015.
PUB
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912763
Grünberger, Alexander. “Microfluidic Single-Cell Cultivation: The key for next generation bioprocess development?”. Presented at the Colloquium Biotechnology, Technical Faculty - Bielefeld University, Bielefeld, 2015.
PUB
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912542
Probst, Christopher, Grünberger, Alexander, Binder, Dennis, Steffen, Iska, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Optical control of gene expression in bacteria on the single-cell level by caged compounds”. Presented at the Synthetic Biology: Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany, 2015.
PUB
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912559
Sachs, Christian Carsten, Helfrich, Stefan, Grünberger, Alexander, Probst, Christopher, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. “High-throughput long-term growth characterization of C. glutamicum on single cell using the Mother Machine”. Presented at the Colloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany, 2015.
PUB
 
2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912566
Grünberger, Alexander, Probst, C., Wiechert, W., and Kohlheyer, D. “Single-Cell Bioreactors: Cutting Edge Cultivation Devices for the Ultimate Scale-Down of Bioprocesses”. Presented at the DECHEMA-Himmelfahrtstagung "Scale-up and scale-down of bioprocesses", Hamburg-Bergedorf, Germany, 2015.
PUB
 
2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912806
Binder, Dennis, Grünberger, Alexander, Loeschcke, Anita, Probst, Christopher, Bier, Claus, Pietruszka, Jörg, Wiechert, Wolfgang, Kohlheyer, Dietrich, Jäger, Karl-Erich, and Drepper, Thomas. “Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers”. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany, 2014.
PUB
 
2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912589
Helfrich, Stefan, Krämer, Christina, Grünberger, Alexander, Azzouzi, Charaf Eddine, Pfeifer, Eugen, Frunzke, Julia, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Nöh, Katharina. “Microfluids as platform for the spatiotemporal analysis of bacterial populations at single-cell level”. Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany, 2014.
PUB
 
2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912591
Grünberger, Alexander, Probst, Christopher, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Microfluidic Single-Cell Cultivation: Opportunity for Industrial Bioprocess Development”. Presented at the EMBL Conference – Microfluidics 2014, Heidelberg, Germany, 2014.
PUB
 
2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912596
Grünberger, Alexander, Probst, Christopher, Unthan, Simon, Mustafi, Nurije, Frunzke, Julia, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “Single-cell cultivation in picoliter scale: Opportunity for bioprocess development”. Presented at the 3rd BioProScale Symposium, Berlin, Germany, 2014.
PUB
 
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912616
Unthan, Simon, Grünberger, Alexander, van Ooyen, Jan, Gätgens, Jochem, Heinrich, Johanna, Paczia, Nicole, Wiechert, Wolfgang, Kohlheyer, Dietrich, and Noack, Stephan. “Beyond growth rate 0.6. What drives Corynebacterium glutamicum to higher growth rates in defined medium”. Biotechnology and bioengineering 111.2 (2014): 359–371.
PUB | DOI | WoS | PubMed | Europe PMC
 
2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912808
Mahr, Regina, Mustafi, Nurije, Grünberger, Alexander, Helfrich, Stefan, Nöh, Katharina, Kohlheyer, Dietrich, and Frunzke, Julia. “Metabolite biosensors for single cell analysis and the development of production strains”. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany, 2014.
PUB
 
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912730
Nanda, Arun M., Heyer, Antonia, Kramer, Christina, Grünberger, Alexander, Kohlheyer, Dietrich, and Frunzke, Julia. “Analysis of SOS-Induced Spontaneous Prophage Induction in Corynebacterium glutamicum at the Single-Cell Level”. Journal of Bacteriology 196.1 (2014): 180-188.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 

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