Chemical constituents of Coccoloba peltata Schott leaves and their cytotoxic activities
Hamed A, El Gaafary M, Fumiko Yamaguchi L, Stammler H-G, Salih LM, Ziegler D, Syrovets T, Kato MJ (2024)
Natural Product Research .
Zeitschriftenaufsatz
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Autor*in
Hamed, Abdelaaty;
El Gaafary, Menna;
Fumiko Yamaguchi, Lydia;
Stammler, Hans-GeorgUniBi;
Salih, Layth M.;
Ziegler, David;
Syrovets, Tatiana;
Kato, Massuo Jorge
Abstract / Bemerkung
Chromatographic fractionation of CH2Cl2:MeOH (1:1) extract of Coccoloba peltata Schott cultivated in Egypt afforded four compounds, lupeol acetate (1), ent-13-epi-manoyl oxide (2), 5-methoxymethyl-7,8-dimethyltocol (3), and alpha-tocopherol quinone (4). The planar structures of the isolated compounds were concluded based on HRESIMS and NMR spectroscopy. X-ray crystallography of 2 is reported herein for the first time and its unambiguous absolute configuration was deduced from anomalous dispersion. To the best of our knowledge, this is the first known report on the isolation of compounds 1-4 from this species. Among the isolated compounds, only compound 4 showed a moderate level of cytotoxic activity against six cancer cell lines out of seven cell lines tested. [GRAPHICS]
Stichworte
Coccoloba peltata;
XRD;
triterpene;
diterpene;
meroterpenoid;
cytotoxic;
activity
Erscheinungsjahr
2024
Zeitschriftentitel
Natural Product Research
ISSN
1478-6419
eISSN
1478-6427
Page URI
https://pub.uni-bielefeld.de/record/2993098
Zitieren
Hamed A, El Gaafary M, Fumiko Yamaguchi L, et al. Chemical constituents of Coccoloba peltata Schott leaves and their cytotoxic activities. Natural Product Research . 2024.
Hamed, A., El Gaafary, M., Fumiko Yamaguchi, L., Stammler, H. - G., Salih, L. M., Ziegler, D., Syrovets, T., et al. (2024). Chemical constituents of Coccoloba peltata Schott leaves and their cytotoxic activities. Natural Product Research . https://doi.org/10.1080/14786419.2024.2405011
Hamed, Abdelaaty, El Gaafary, Menna, Fumiko Yamaguchi, Lydia, Stammler, Hans-Georg, Salih, Layth M., Ziegler, David, Syrovets, Tatiana, and Kato, Massuo Jorge. 2024. “Chemical constituents of Coccoloba peltata Schott leaves and their cytotoxic activities”. Natural Product Research .
Hamed, A., El Gaafary, M., Fumiko Yamaguchi, L., Stammler, H. - G., Salih, L. M., Ziegler, D., Syrovets, T., and Kato, M. J. (2024). Chemical constituents of Coccoloba peltata Schott leaves and their cytotoxic activities. Natural Product Research .
Hamed, A., et al., 2024. Chemical constituents of Coccoloba peltata Schott leaves and their cytotoxic activities. Natural Product Research .
A. Hamed, et al., “Chemical constituents of Coccoloba peltata Schott leaves and their cytotoxic activities”, Natural Product Research , 2024.
Hamed, A., El Gaafary, M., Fumiko Yamaguchi, L., Stammler, H.-G., Salih, L.M., Ziegler, D., Syrovets, T., Kato, M.J.: Chemical constituents of Coccoloba peltata Schott leaves and their cytotoxic activities. Natural Product Research . (2024).
Hamed, Abdelaaty, El Gaafary, Menna, Fumiko Yamaguchi, Lydia, Stammler, Hans-Georg, Salih, Layth M., Ziegler, David, Syrovets, Tatiana, and Kato, Massuo Jorge. “Chemical constituents of Coccoloba peltata Schott leaves and their cytotoxic activities”. Natural Product Research (2024).
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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Daten bereitgestellt von Europe PubMed Central.
References
Daten bereitgestellt von Europe PubMed Central.
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