Photocleavable Polymer Cubosomes: Synthesis, Self-Assembly, and Photorelease
Chen H, Schumacher M, Ianiro A, Stank TJ, Janoszka N, Chen C, Azhdari S, Hellweg T, Gröschel AH (2024)
Journal of the American Chemical Society.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Chen, Hui;
Schumacher, Marcel;
Ianiro, Alessandro;
Stank, Tim JulianUniBi;
Janoszka, Nicole;
Chen, Chen;
Azhdari, Suna;
Hellweg, ThomasUniBi
;
Gröschel, André H.
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Abstract / Bemerkung
Polymer cubosomes (PCs) are a recent class of self-assembled block copolymer (BCP) microparticles with an accessible periodic channel system. Most reported PCs consist of a polystyrene scaffold, which provides mechanical stability for templating but has a limited intrinsic functionality. Here, we report the synthesis of photocleavable BCPs with compositions suitable for PC formation. We analyze the self-assembly mechanism and study the model release of dyes during irradiation, where the transition of the BCPs from amphiphilic to bishydrophilic causes the rapid disassembly of the PCs. A combination of modeling and experiment shows that the evolution of PCs proceeds first via liquid–liquid phase separation into polymer-rich droplets, followed by microphase separation within this droplet confinement, and finally, membrane reorganization into high internal order. This insight may encourage exploration of alternative preparation strategies to better control the size and homogeneity of PCs.
Erscheinungsjahr
2024
Zeitschriftentitel
Journal of the American Chemical Society
ISSN
0002-7863
eISSN
1520-5126
Page URI
https://pub.uni-bielefeld.de/record/2988866
Zitieren
Chen H, Schumacher M, Ianiro A, et al. Photocleavable Polymer Cubosomes: Synthesis, Self-Assembly, and Photorelease. Journal of the American Chemical Society. 2024.
Chen, H., Schumacher, M., Ianiro, A., Stank, T. J., Janoszka, N., Chen, C., Azhdari, S., et al. (2024). Photocleavable Polymer Cubosomes: Synthesis, Self-Assembly, and Photorelease. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.4c02651
Chen, Hui, Schumacher, Marcel, Ianiro, Alessandro, Stank, Tim Julian, Janoszka, Nicole, Chen, Chen, Azhdari, Suna, Hellweg, Thomas, and Gröschel, André H. 2024. “Photocleavable Polymer Cubosomes: Synthesis, Self-Assembly, and Photorelease”. Journal of the American Chemical Society.
Chen, H., Schumacher, M., Ianiro, A., Stank, T. J., Janoszka, N., Chen, C., Azhdari, S., Hellweg, T., and Gröschel, A. H. (2024). Photocleavable Polymer Cubosomes: Synthesis, Self-Assembly, and Photorelease. Journal of the American Chemical Society.
Chen, H., et al., 2024. Photocleavable Polymer Cubosomes: Synthesis, Self-Assembly, and Photorelease. Journal of the American Chemical Society.
H. Chen, et al., “Photocleavable Polymer Cubosomes: Synthesis, Self-Assembly, and Photorelease”, Journal of the American Chemical Society, 2024.
Chen, H., Schumacher, M., Ianiro, A., Stank, T.J., Janoszka, N., Chen, C., Azhdari, S., Hellweg, T., Gröschel, A.H.: Photocleavable Polymer Cubosomes: Synthesis, Self-Assembly, and Photorelease. Journal of the American Chemical Society. (2024).
Chen, Hui, Schumacher, Marcel, Ianiro, Alessandro, Stank, Tim Julian, Janoszka, Nicole, Chen, Chen, Azhdari, Suna, Hellweg, Thomas, and Gröschel, André H. “Photocleavable Polymer Cubosomes: Synthesis, Self-Assembly, and Photorelease”. Journal of the American Chemical Society (2024).
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