Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells
Schmidt KE, Höving AL, Nowak K, an Mey N, Kiani Zahrani S, Nemeita B, Riedel L, Majewski A, Kaltschmidt B, Knabbe C, Kaltschmidt C (2024)
International Journal of Molecular Sciences 25(7): 3593.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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ijms-25-03593-v2.pdf
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Autor*in
Schmidt, Kazuko E.;
Höving, Anna L.;
Nowak, Katja;
an Mey, Nike;
Kiani Zahrani, Sina;
Nemeita, BrittaUniBi;
Riedel, Lena;
Majewski, Agnes;
Kaltschmidt, Barbara;
Knabbe, CorneliusUniBi;
Kaltschmidt, ChristianUniBi
Einrichtung
Abstract / Bemerkung
Cardiovascular diseases (CVDs) are often linked to ageing and are the major cause of death worldwide. The declined proliferation of adult stem cells in the heart often impedes its regenerative potential. Thus, an investigation of the proliferative potential of adult human cardiac stem cells (hCSCs) might be of great interest for improving cell-based treatments of cardiovascular diseases. The application of human blood serum was already shown to enhance hCSC proliferation and reduce senescence. Here, the underlying signalling pathways of serum-mediated hCSC proliferation were studied. We are the first to demonstrate the involvement of the transcription factor NF-κB in the serum-mediated proliferative response of hCSCs by utilizing the NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC). RNA-Sequencing (RNA-Seq) revealed ATF6B, COX5B, and TNFRSF14 as potential targets of NF-κB that are involved in serum-induced hCSC proliferation.
Stichworte
human cardiac stem cells;
proliferation;
human blood serum;
NF-κB;
PDTC;
RNA-Seq
Erscheinungsjahr
2024
Zeitschriftentitel
International Journal of Molecular Sciences
Band
25
Ausgabe
7
Art.-Nr.
3593
Urheberrecht / Lizenzen
eISSN
1422-0067
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2988366
Zitieren
Schmidt KE, Höving AL, Nowak K, et al. Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells. International Journal of Molecular Sciences. 2024;25(7): 3593.
Schmidt, K. E., Höving, A. L., Nowak, K., an Mey, N., Kiani Zahrani, S., Nemeita, B., Riedel, L., et al. (2024). Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells. International Journal of Molecular Sciences, 25(7), 3593. https://doi.org/10.3390/ijms25073593
Schmidt, Kazuko E., Höving, Anna L., Nowak, Katja, an Mey, Nike, Kiani Zahrani, Sina, Nemeita, Britta, Riedel, Lena, et al. 2024. “Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells”. International Journal of Molecular Sciences 25 (7): 3593.
Schmidt, K. E., Höving, A. L., Nowak, K., an Mey, N., Kiani Zahrani, S., Nemeita, B., Riedel, L., Majewski, A., Kaltschmidt, B., Knabbe, C., et al. (2024). Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells. International Journal of Molecular Sciences 25:3593.
Schmidt, K.E., et al., 2024. Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells. International Journal of Molecular Sciences, 25(7): 3593.
K.E. Schmidt, et al., “Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells”, International Journal of Molecular Sciences, vol. 25, 2024, : 3593.
Schmidt, K.E., Höving, A.L., Nowak, K., an Mey, N., Kiani Zahrani, S., Nemeita, B., Riedel, L., Majewski, A., Kaltschmidt, B., Knabbe, C., Kaltschmidt, C.: Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells. International Journal of Molecular Sciences. 25, : 3593 (2024).
Schmidt, Kazuko E., Höving, Anna L., Nowak, Katja, an Mey, Nike, Kiani Zahrani, Sina, Nemeita, Britta, Riedel, Lena, Majewski, Agnes, Kaltschmidt, Barbara, Knabbe, Cornelius, and Kaltschmidt, Christian. “Serum Induces the Subunit-Specific Activation of NF-κB in Proliferating Human Cardiac Stem Cells”. International Journal of Molecular Sciences 25.7 (2024): 3593.
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