Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline

Karalija N, Papenberg G, Johansson J, Wahlin A, Salami A, Andersson M, Axelsson J, Kuznetsov D, Riklund K, Lovden M, Lindenberger U, et al. (2024)
Neurobiology of Aging 136: 125-132.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Karalija, Nina; Papenberg, Goran; Johansson, Jarkko; Wahlin, Anders; Salami, Alireza; Andersson, Micael; Axelsson, Jan; Kuznetsov, DmitryUniBi; Riklund, Katrine; Lovden, Martin; Lindenberger, Ulman; Backman, Lars
Alle
Abstract / Bemerkung
Dopamine decline is suggested to underlie aging -related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5 -year longitudinal data for a sample of healthy, older adults (baseline: n = 181, age: 64-68 years; 5 -year follow-up: n = 129) who underwent positron emission tomography with 11C- raclopride to assess dopamine D2 -like receptor (DRD2) availability, magnetic resonance imaging to evaluate structural brain measures, and cognitive tests. Health, lifestyle, and genetic data were also collected. A datadriven approach (k -means cluster analysis) identified groups that differed maximally in DRD2 decline rates in age -sensitive brain regions. One group (n = 47) had DRD2 decline exclusively in the caudate and no cognitive decline. A second group (n = 72) had more wide -ranged DRD2 decline in putamen and nucleus accumbens and also in extrastriatal regions. The latter group showed significant 5 -year working memory decline that correlated with putamen DRD2 decline, along with higher dementia and cardiovascular risk and a faster biological pace of aging. Taken together, for individuals with more extensive DRD2 decline, dopamine decline is associated with memory decline in aging.
Stichworte
Aging; Longitudinal; Working memory; Positron emission tomography; 11; C-raclopride; Magnetic resonance imaging; Dopamine D2-like receptor
Erscheinungsjahr
2024
Zeitschriftentitel
Neurobiology of Aging
Band
136
Seite(n)
125-132
ISSN
0197-4580
eISSN
1558-1497
Page URI
https://pub.uni-bielefeld.de/record/2988239

Zitieren

Karalija N, Papenberg G, Johansson J, et al. Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline. Neurobiology of Aging. 2024;136:125-132.
Karalija, N., Papenberg, G., Johansson, J., Wahlin, A., Salami, A., Andersson, M., Axelsson, J., et al. (2024). Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline. Neurobiology of Aging, 136, 125-132. https://doi.org/10.1016/j.neurobiolaging.2024.02.001
Karalija, Nina, Papenberg, Goran, Johansson, Jarkko, Wahlin, Anders, Salami, Alireza, Andersson, Micael, Axelsson, Jan, et al. 2024. “Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline”. Neurobiology of Aging 136: 125-132.
Karalija, N., Papenberg, G., Johansson, J., Wahlin, A., Salami, A., Andersson, M., Axelsson, J., Kuznetsov, D., Riklund, K., Lovden, M., et al. (2024). Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline. Neurobiology of Aging 136, 125-132.
Karalija, N., et al., 2024. Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline. Neurobiology of Aging, 136, p 125-132.
N. Karalija, et al., “Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline”, Neurobiology of Aging, vol. 136, 2024, pp. 125-132.
Karalija, N., Papenberg, G., Johansson, J., Wahlin, A., Salami, A., Andersson, M., Axelsson, J., Kuznetsov, D., Riklund, K., Lovden, M., Lindenberger, U., Backman, L., Nyberg, L.: Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline. Neurobiology of Aging. 136, 125-132 (2024).
Karalija, Nina, Papenberg, Goran, Johansson, Jarkko, Wahlin, Anders, Salami, Alireza, Andersson, Micael, Axelsson, Jan, Kuznetsov, Dmitry, Riklund, Katrine, Lovden, Martin, Lindenberger, Ulman, Backman, Lars, and Nyberg, Lars. “Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline”. Neurobiology of Aging 136 (2024): 125-132.

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