Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae)
Tsafack VC, Dongmo AK, Nono RN, Tabekoueng GB, Neumann B, Stammler H-G, Bankeu JJK, Kouame SF, Nkeng-Efouet-Alango P, Lenta BN, Sewald N, et al. (2024)
Phytochemistry Letters 59: 53-58.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Tsafack, Vanessa CharneleUniBi;
Dongmo, Appolinaire Kene;
Nono, Raymond Ngansop;
Tabekoueng, Georges BellierUniBi;
Neumann, BeateUniBi;
Stammler, Hans-GeorgUniBi;
Bankeu, Jean Jules Kezetas;
Kouame, Simeon Fogue;
Nkeng-Efouet-Alango, Pepin;
Lenta, Bruno Ndjakou;
Sewald, NorbertUniBi 
;
Chouna, Jean RodolpheUniBi
;
Chouna, Jean RodolpheUniBiEinrichtung
Abstract / Bemerkung
A new xanthone glycoside (1) and a new bufadienolide (2) named bersamaxanthoside and bersamabufadienolide, respectively, together with seventeen known compounds (3-19) were isolated from the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. Their structures were elucidated based on their spectroscopic data. The extract, fractions and compounds were assessed for their cytotoxicity on the cervix carcinoma cell line KB-3-1. The MeOH extract and the EtOAc and n-BuOH soluble fractions exhibited weak activity with IC50 values of 0.085, 0.084 and 0.075 mg/mL, respectively. The other tested samples were inactive. In addition, some of the isolates were tested for their DPPH radical scavenging activity and only compounds 1, 11-13, 16, and 17 displayed antioxidant properties with IC50 values ranging from 2.9 to 38.1 mu g/mL.
Stichworte
Bersama abyssinica;
Melianthaceae;
Xanthone glycoside;
Bufadienolide;
Cytotoxicity;
Antioxidant
Erscheinungsjahr
2024
Zeitschriftentitel
Phytochemistry Letters
Band
59
Seite(n)
53-58
ISSN
1874-3900
eISSN
1876-7486
Page URI
https://pub.uni-bielefeld.de/record/2986693
Zitieren
Tsafack VC, Dongmo AK, Nono RN, et al. Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae). Phytochemistry Letters . 2024;59:53-58.
Tsafack, V. C., Dongmo, A. K., Nono, R. N., Tabekoueng, G. B., Neumann, B., Stammler, H. - G., Bankeu, J. J. K., et al. (2024). Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae). Phytochemistry Letters , 59, 53-58. https://doi.org/10.1016/j.phytol.2023.12.003
Tsafack, Vanessa Charnele, Dongmo, Appolinaire Kene, Nono, Raymond Ngansop, Tabekoueng, Georges Bellier, Neumann, Beate, Stammler, Hans-Georg, Bankeu, Jean Jules Kezetas, et al. 2024. “Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae)”. Phytochemistry Letters 59: 53-58.
Tsafack, V. C., Dongmo, A. K., Nono, R. N., Tabekoueng, G. B., Neumann, B., Stammler, H. - G., Bankeu, J. J. K., Kouame, S. F., Nkeng-Efouet-Alango, P., Lenta, B. N., et al. (2024). Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae). Phytochemistry Letters 59, 53-58.
Tsafack, V.C., et al., 2024. Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae). Phytochemistry Letters , 59, p 53-58.
V.C. Tsafack, et al., “Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae)”, Phytochemistry Letters , vol. 59, 2024, pp. 53-58.
Tsafack, V.C., Dongmo, A.K., Nono, R.N., Tabekoueng, G.B., Neumann, B., Stammler, H.-G., Bankeu, J.J.K., Kouame, S.F., Nkeng-Efouet-Alango, P., Lenta, B.N., Sewald, N., Chouna, J.R.: Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae). Phytochemistry Letters . 59, 53-58 (2024).
Tsafack, Vanessa Charnele, Dongmo, Appolinaire Kene, Nono, Raymond Ngansop, Tabekoueng, Georges Bellier, Neumann, Beate, Stammler, Hans-Georg, Bankeu, Jean Jules Kezetas, Kouame, Simeon Fogue, Nkeng-Efouet-Alango, Pepin, Lenta, Bruno Ndjakou, Sewald, Norbert, and Chouna, Jean Rodolphe. “Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae)”. Phytochemistry Letters 59 (2024): 53-58.
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