Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns
Steinmann M, Lampe D, Grosser J, Schmidt J, Hohoff ML, Fischer A, Greiner W (2024)
Infection.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Steinmann, MarenUniBi
;
Lampe, DavidUniBi
;
Grosser, JohnUniBi
;
Schmidt, JulianaUniBi;
Hohoff, Marla Louise;
Fischer, Anita;
Greiner, WolfgangUniBi
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![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
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Einrichtung
Abstract / Bemerkung
**Purpose**
The burden of herpes zoster (HZ) is substantial and numerous chronic underlying conditions are known as predisposing risk factors for HZ onset. Thus, a comprehensive study is needed to synthesize existing evidence. This study aims to comprehensively identify these risk factors. **Methods**
A systematic literature search was done using MEDLINE via PubMed, EMBASE and Web of Science for studies published from January 1, 2003 to January 1, 2023. A random-effects model was used to estimate pooled Odds Ratios (OR). Heterogeneity was assessed using theI2statistic. For sensitivity analyses basic outlier removal, leave-one-out validation and Graphic Display of Heterogeneity (GOSH) plots with different algorithms were employed to further analyze heterogeneity patterns. Finally, a multiple meta-regression was conducted. **Results**
Of 6392 considered records, 80 were included in the meta-analysis. 21 different conditions were identified as potential risk factors for HZ: asthma, autoimmune disorders, cancer, cardiovascular disorders, chronic heart failure (CHF), chronic obstructive pulmonary disorder (COPD), depression, diabetes, digestive disorders, endocrine and metabolic disorders, hematological disorders, HIV, inflammatory bowel disease (IBD), mental health conditions, musculoskeletal disorders, neurological disorders, psoriasis, renal disorders, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and transplantation. Transplantation was associated with the highest risk of HZ (OR = 4.51 (95% CI [1.9–10.7])). Other risk factors ranged from OR = 1.17–2.87, indicating an increased risk for all underlying conditions. Heterogeneity was substantial in all provided analyses. Sensitivity analyses showed comparable results regarding the pooled effects and heterogeneity. **Conclusions**
This study showed an increased risk of HZ infections for all identified factors.
The burden of herpes zoster (HZ) is substantial and numerous chronic underlying conditions are known as predisposing risk factors for HZ onset. Thus, a comprehensive study is needed to synthesize existing evidence. This study aims to comprehensively identify these risk factors. **Methods**
A systematic literature search was done using MEDLINE via PubMed, EMBASE and Web of Science for studies published from January 1, 2003 to January 1, 2023. A random-effects model was used to estimate pooled Odds Ratios (OR). Heterogeneity was assessed using theI2statistic. For sensitivity analyses basic outlier removal, leave-one-out validation and Graphic Display of Heterogeneity (GOSH) plots with different algorithms were employed to further analyze heterogeneity patterns. Finally, a multiple meta-regression was conducted. **Results**
Of 6392 considered records, 80 were included in the meta-analysis. 21 different conditions were identified as potential risk factors for HZ: asthma, autoimmune disorders, cancer, cardiovascular disorders, chronic heart failure (CHF), chronic obstructive pulmonary disorder (COPD), depression, diabetes, digestive disorders, endocrine and metabolic disorders, hematological disorders, HIV, inflammatory bowel disease (IBD), mental health conditions, musculoskeletal disorders, neurological disorders, psoriasis, renal disorders, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and transplantation. Transplantation was associated with the highest risk of HZ (OR = 4.51 (95% CI [1.9–10.7])). Other risk factors ranged from OR = 1.17–2.87, indicating an increased risk for all underlying conditions. Heterogeneity was substantial in all provided analyses. Sensitivity analyses showed comparable results regarding the pooled effects and heterogeneity. **Conclusions**
This study showed an increased risk of HZ infections for all identified factors.
Stichworte
Herpes zoster;
Risk factors;
Meta-analysis;
Systematic review;
Random-effects model;
Meta-regression
Erscheinungsjahr
2024
Zeitschriftentitel
Infection
Urheberrecht / Lizenzen
ISSN
0300-8126
eISSN
1439-0973
Page URI
https://pub.uni-bielefeld.de/record/2986211
Zitieren
Steinmann M, Lampe D, Grosser J, et al. Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns. Infection. 2024.
Steinmann, M., Lampe, D., Grosser, J., Schmidt, J., Hohoff, M. L., Fischer, A., & Greiner, W. (2024). Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns. Infection. https://doi.org/10.1007/s15010-023-02156-y
Steinmann, Maren, Lampe, David, Grosser, John, Schmidt, Juliana, Hohoff, Marla Louise, Fischer, Anita, and Greiner, Wolfgang. 2024. “Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns”. Infection.
Steinmann, M., Lampe, D., Grosser, J., Schmidt, J., Hohoff, M. L., Fischer, A., and Greiner, W. (2024). Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns. Infection.
Steinmann, M., et al., 2024. Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns. Infection.
M. Steinmann, et al., “Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns”, Infection, 2024.
Steinmann, M., Lampe, D., Grosser, J., Schmidt, J., Hohoff, M.L., Fischer, A., Greiner, W.: Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns. Infection. (2024).
Steinmann, Maren, Lampe, David, Grosser, John, Schmidt, Juliana, Hohoff, Marla Louise, Fischer, Anita, and Greiner, Wolfgang. “Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns”. Infection (2024).
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Preprint: 10.21203/rs.3.rs-3486245/v1
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