Genetic Gating of Human Fear Learning and Extinction

Lonsdorf T, Weike AI, Nikamo P, Schalling M, Hamm AO, Öhman A (2009)
Psychological Science 20(2): 198-206.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Lonsdorf, TinaUniBi; Weike, Almut I.; Nikamo, Pernilla; Schalling, Martin; Hamm, Alfons O.; Öhman, Arne
Alternativer Titel
Possible Implications for Gene-Environment Interaction in Anxiety Disorder
Abstract / Bemerkung
Pavlovian fear conditioning is a widely used model of the acquisition and extinction of fear. Neural findings suggest that the amygdala is the core structure for fear acquisition, whereas prefrontal cortical areas are given pivotal roles in fear extinction. Forty-eight volunteers participated in a fear-conditioning experiment, which used fear potentiation of the startle reflex as the primary measure to investigate the effect of two genetic polymorphisms (5-HTTLPR and COMTval158met) on conditioning and extinction of fear. The 5-HTTLPR polymorphism, located in the serotonin transporter gene, is associated with amygdala reactivity and neuroticism, whereas the COMTval158met polymorphism, which is located in the gene coding for catechol-O-methyltransferase (COMT), a dopamine-degrading enzyme, affects prefrontal executive functions. Our results show that only carriers of the 5-HTTLPR s allele exhibited conditioned startle potentiation, whereas carriers of the COMT met/met genotype failed to extinguish conditioned fear. These results may have interesting implications for understanding gene-environment interactions in the development and treatment of anxiety disorders.
Erscheinungsjahr
2009
Zeitschriftentitel
Psychological Science
Band
20
Ausgabe
2
Seite(n)
198-206
ISSN
0956-7976
eISSN
1467-9280
Page URI
https://pub.uni-bielefeld.de/record/2985408

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Lonsdorf T, Weike AI, Nikamo P, Schalling M, Hamm AO, Öhman A. Genetic Gating of Human Fear Learning and Extinction. Psychological Science. 2009;20(2):198-206.
Lonsdorf, T., Weike, A. I., Nikamo, P., Schalling, M., Hamm, A. O., & Öhman, A. (2009). Genetic Gating of Human Fear Learning and Extinction. Psychological Science, 20(2), 198-206. https://doi.org/10.1111/j.1467-9280.2009.02280.x
Lonsdorf, Tina, Weike, Almut I., Nikamo, Pernilla, Schalling, Martin, Hamm, Alfons O., and Öhman, Arne. 2009. “Genetic Gating of Human Fear Learning and Extinction”. Psychological Science 20 (2): 198-206.
Lonsdorf, T., Weike, A. I., Nikamo, P., Schalling, M., Hamm, A. O., and Öhman, A. (2009). Genetic Gating of Human Fear Learning and Extinction. Psychological Science 20, 198-206.
Lonsdorf, T., et al., 2009. Genetic Gating of Human Fear Learning and Extinction. Psychological Science, 20(2), p 198-206.
T. Lonsdorf, et al., “Genetic Gating of Human Fear Learning and Extinction”, Psychological Science, vol. 20, 2009, pp. 198-206.
Lonsdorf, T., Weike, A.I., Nikamo, P., Schalling, M., Hamm, A.O., Öhman, A.: Genetic Gating of Human Fear Learning and Extinction. Psychological Science. 20, 198-206 (2009).
Lonsdorf, Tina, Weike, Almut I., Nikamo, Pernilla, Schalling, Martin, Hamm, Alfons O., and Öhman, Arne. “Genetic Gating of Human Fear Learning and Extinction”. Psychological Science 20.2 (2009): 198-206.
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