Performance of the Sofia SARS-CoV-2 rapid antigen test as frontline test in a university hospital, Germany
Bornemann L, Dähne T, Fomenko A, Kaup O, Kleideiter J, Kulis-Horn R, Ruprecht B, Wehmeier M, Panning M (2022)
Diagnostic Microbiology and Infectious Disease 103(1): 115663.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Bornemann, Linus;
Dähne, Theo;
Fomenko, Alexey;
Kaup, OlafUniBi 
;
Kleideiter, Johannes;
Kulis-Horn, RobertUniBi;
Ruprecht, BertramUniBi;
Wehmeier, Michael;
Panning, Marcus
;
Kleideiter, Johannes;
Kulis-Horn, RobertUniBi;
Ruprecht, BertramUniBi;
Wehmeier, Michael;
Panning, MarcusEinrichtung
Abstract / Bemerkung
The rapid and reliable detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of high importance for individual patient care and hospital infection prevention. We aimed to evaluate the performance of the Sofia SARS-CoV-2 antigen rapid diagnostic test (Ag-RDT) in comparison to real-time reverse-transcription polymerase chain reaction (RT-PCR). We conducted a prospective, monocentric cross-sectional study in an emergency department of a German university hospital from November 2020 to March 2021. We tested all samples using both Sofia SARS-CoV-2 Ag-RDT and real-time RT-PCR. A total of 7877 patients were included. Overall sensitivity of the Ag-RDT was 62.9% and specificity was 99.4%. Sensitivity varied across study months, whereas specificity remained high. Sensitivity increased to 94.2% in samples with a cycle threshold (Ct)-value ≤25. The Sofia Ag-RDT proved to be a rapid tool to detect samples with high viral loads (Ct-value ≤25) and might thus help to identify infectious patients.
Erscheinungsjahr
2022
Zeitschriftentitel
Diagnostic Microbiology and Infectious Disease
Band
103
Ausgabe
1
Art.-Nr.
115663
ISSN
07328893
Page URI
https://pub.uni-bielefeld.de/record/2984040
Zitieren
Bornemann L, Dähne T, Fomenko A, et al. Performance of the Sofia SARS-CoV-2 rapid antigen test as frontline test in a university hospital, Germany. Diagnostic Microbiology and Infectious Disease. 2022;103(1): 115663.
Bornemann, L., Dähne, T., Fomenko, A., Kaup, O., Kleideiter, J., Kulis-Horn, R., Ruprecht, B., et al. (2022). Performance of the Sofia SARS-CoV-2 rapid antigen test as frontline test in a university hospital, Germany. Diagnostic Microbiology and Infectious Disease, 103(1), 115663. https://doi.org/10.1016/j.diagmicrobio.2022.115663
Bornemann, Linus, Dähne, Theo, Fomenko, Alexey, Kaup, Olaf, Kleideiter, Johannes, Kulis-Horn, Robert, Ruprecht, Bertram, Wehmeier, Michael, and Panning, Marcus. 2022. “Performance of the Sofia SARS-CoV-2 rapid antigen test as frontline test in a university hospital, Germany”. Diagnostic Microbiology and Infectious Disease 103 (1): 115663.
Bornemann, L., Dähne, T., Fomenko, A., Kaup, O., Kleideiter, J., Kulis-Horn, R., Ruprecht, B., Wehmeier, M., and Panning, M. (2022). Performance of the Sofia SARS-CoV-2 rapid antigen test as frontline test in a university hospital, Germany. Diagnostic Microbiology and Infectious Disease 103:115663.
Bornemann, L., et al., 2022. Performance of the Sofia SARS-CoV-2 rapid antigen test as frontline test in a university hospital, Germany. Diagnostic Microbiology and Infectious Disease, 103(1): 115663.
L. Bornemann, et al., “Performance of the Sofia SARS-CoV-2 rapid antigen test as frontline test in a university hospital, Germany”, Diagnostic Microbiology and Infectious Disease, vol. 103, 2022, : 115663.
Bornemann, L., Dähne, T., Fomenko, A., Kaup, O., Kleideiter, J., Kulis-Horn, R., Ruprecht, B., Wehmeier, M., Panning, M.: Performance of the Sofia SARS-CoV-2 rapid antigen test as frontline test in a university hospital, Germany. Diagnostic Microbiology and Infectious Disease. 103, : 115663 (2022).
Bornemann, Linus, Dähne, Theo, Fomenko, Alexey, Kaup, Olaf, Kleideiter, Johannes, Kulis-Horn, Robert, Ruprecht, Bertram, Wehmeier, Michael, and Panning, Marcus. “Performance of the Sofia SARS-CoV-2 rapid antigen test as frontline test in a university hospital, Germany”. Diagnostic Microbiology and Infectious Disease 103.1 (2022): 115663.
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