Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies
Hamed A, Abdel-Razek AS, Abdelwahab AHMEDB, El Taweel A, Gaballah M, Sewald N, Shaaban M (2023) .
Preprint
| Veröffentlicht | Englisch
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Autor*in
Hamed, Abdelaaty;
Abdel-Razek, Ahmed S.;
Abdelwahab, AHMED B;
El Taweel, Ahmed;
Gaballah, Mohamed;
Sewald, NorbertUniBi ;
Shaaban, Mohamed
Einrichtung
Abstract / Bemerkung
The recently reported microbial natural product N-benzoyl-tryptophane (1) along with twenty-two diverse known bioactive compounds were isolated from the marine Aspergillus terreus LGO13 after its re-cultivation using liquid culture fermentation. Structures of the isolated compounds were established on the basis of HR-ESIMS 1D/2D NMR spectroscopy, and comparison with literature data. The antimicrobial, cytotoxicity, and antiviral activities of the microbial extract and the obtained compounds were investigated using a set of microorganisms, cervix carcinoma KB-3-1, non-small cell lung cancer (NSCLC) A549, and coronavirus (SARS-CoV-2), respectively. Molecular docking (MD) simulation was employed to explore the theoretical targets of the isolated metabolites as anti-SARS-CoV-2 agents. Chaetominine (2) seemed to be a potential candidate against papain-like protease (PLpro), one of the viral proteins being aimed by recent research as a possible target of anti-covid agents. Inspired by the MD results, we accordingly assessed the antiviral efficacy of chaetominine (2), fumitremorgin C (6), and azaspirofuran A (9) against SARS-CoV-2. Fumitremorgin C (6) showed a high selectivity index (SI = 20.3), while chaetominine (2) and azaspirofuran A (9) showed moderate selectivity index (SI = 6.6 and 3.2, respectively). These results showed a promising antiviral activity of Fumitremorgin C against SARS-CoV-2 virus.
Erscheinungsjahr
2023
Urheberrecht / Lizenzen
Page URI
https://pub.uni-bielefeld.de/record/2983145
Zitieren
Hamed A, Abdel-Razek AS, Abdelwahab AHMEDB, et al. Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies. 2023.
Hamed, A., Abdel-Razek, A. S., Abdelwahab, A. H. M. E. D. B., El Taweel, A., Gaballah, M., Sewald, N., & Shaaban, M. (2023). Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies. https://doi.org/10.20944/preprints202309.1552.v1
Hamed, Abdelaaty, Abdel-Razek, Ahmed S., Abdelwahab, AHMED B, El Taweel, Ahmed, Gaballah, Mohamed, Sewald, Norbert, and Shaaban, Mohamed. 2023. “Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies”.
Hamed, A., Abdel-Razek, A. S., Abdelwahab, A. H. M. E. D. B., El Taweel, A., Gaballah, M., Sewald, N., and Shaaban, M. (2023). Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies.
Hamed, A., et al., 2023. Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies.
A. Hamed, et al., “Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies”, 2023.
Hamed, A., Abdel-Razek, A.S., Abdelwahab, A.H.M.E.D.B., El Taweel, A., Gaballah, M., Sewald, N., Shaaban, M.: Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies. (2023).
Hamed, Abdelaaty, Abdel-Razek, Ahmed S., Abdelwahab, AHMED B, El Taweel, Ahmed, Gaballah, Mohamed, Sewald, Norbert, and Shaaban, Mohamed. “Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies”. (2023).