Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance

Tseme Wandji, Nadine; Bitchagno, Gabin Thierry M.; Mawabo Kamga, Isabelle; Tchamgoue, Joseph; Nkenfou, Celine Nguefeu; Lenta, Bruno Ndjakou; Sewald, Norbert; Kouam, Simeon Fogue

Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance

Tseme Wandji N, Bitchagno GTM, Mawabo Kamga I, Tchamgoue J, Nkenfou CN, Lenta BN, Sewald N, Kouam SF (2023)
Molecules 28(13): 5278.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.3390/molecules28135278

URN

urn:nbn:de:0070-pub-29807167

Autor*in

Tseme Wandji, Nadine; Bitchagno, Gabin Thierry M.; Mawabo Kamga, Isabelle; Tchamgoue, Joseph; Nkenfou, Celine Nguefeu; Lenta, Bruno Ndjakou; Sewald, Norbert^UniBi ; Kouam, Simeon Fogue

Einrichtung

Centrum für Biotechnologie
Fakultät für Chemie > Organische Chemie III

Abstract / Bemerkung

Four polyoxygenated stigmastanes (1–4) alongside known analogues (7–8) and flavonoids (5–6) were isolated from a dichloromethane/methanol (1:1, v/v) extract of the whole plant of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Their structures were determined by means of spectroscopic and spectrometric analysis. The relative stereochemistry of the new compounds was established and confirmed via biosynthesis evidence and cyclization of 1 under acidic conditions. A plausible biosynthetic pathway to the new compounds and the chemophenetic significance of the isolated constituents were also discussed. The crude extract, fractions, and compounds (1–3) were assessed for their antibacterial activity against five highly prevalent bacterial strains. The fractions and compounds showed low to moderate activity with minimal inhibitory concentrations (MICs) > 125 µg/mL.

Stichworte

Vernonia kotschyana; Asteraceae; stigmastanes; structure elucidation; chemophenetic significance; antibacterial activity

Erscheinungsjahr

2023

Zeitschriftentitel

Molecules

Band

Ausgabe

Art.-Nr.

5278

Urheberrecht / Lizenzen

Creative Commons Namensnennung 4.0 International Public License (CC-BY 4.0)

eISSN

1420-3049

Page URI

https://pub.uni-bielefeld.de/record/2980716

Zitieren

Tseme Wandji N, Bitchagno GTM, Mawabo Kamga I, et al. Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance. Molecules. 2023;28(13): 5278.

Tseme Wandji, N., Bitchagno, G. T. M., Mawabo Kamga, I., Tchamgoue, J., Nkenfou, C. N., Lenta, B. N., Sewald, N., et al. (2023). Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance. Molecules, 28(13), 5278. https://doi.org/10.3390/molecules28135278

Tseme Wandji, Nadine, Bitchagno, Gabin Thierry M., Mawabo Kamga, Isabelle, Tchamgoue, Joseph, Nkenfou, Celine Nguefeu, Lenta, Bruno Ndjakou, Sewald, Norbert, and Kouam, Simeon Fogue. 2023. “Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance”. Molecules 28 (13): 5278.

Tseme Wandji, N., Bitchagno, G. T. M., Mawabo Kamga, I., Tchamgoue, J., Nkenfou, C. N., Lenta, B. N., Sewald, N., and Kouam, S. F. (2023). Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance. Molecules 28:5278.

Tseme Wandji, N., et al., 2023. Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance. Molecules, 28(13): 5278.

N. Tseme Wandji, et al., “Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance”, Molecules, vol. 28, 2023, : 5278.

Tseme Wandji, N., Bitchagno, G.T.M., Mawabo Kamga, I., Tchamgoue, J., Nkenfou, C.N., Lenta, B.N., Sewald, N., Kouam, S.F.: Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance. Molecules. 28, : 5278 (2023).

Tseme Wandji, Nadine, Bitchagno, Gabin Thierry M., Mawabo Kamga, Isabelle, Tchamgoue, Joseph, Nkenfou, Celine Nguefeu, Lenta, Bruno Ndjakou, Sewald, Norbert, and Kouam, Simeon Fogue. “Polyoxygenated Stigmastane-Type Steroids from Vernonia kotschyana Sch. Bip. ex Walp. and Their Chemophenetic Significance”. Molecules 28.13 (2023): 5278.

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