Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort

Walter Costa MB, Gärtner C, Schmidt M, Berg T, Seehofer D, Kaiser T (2023)
Journal of Personalized Medicine 13(6): 963.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Walter Costa, Maria Beatriz; Gärtner, ChristianeUniBi; Schmidt, Maria; Berg, Thomas; Seehofer, Daniel; Kaiser, ThorstenUniBi
Abstract / Bemerkung
(1) Background: Prioritization of patients for liver transplantation in Germany relies on the MELD (model for end-stage liver disease) scoring system that does not consider the patient’s sex. Many studies have shown that women are disadvantaged by the MELD score. Using a large patient cohort from a German liver transplant centre, we investigated options to reduce gender inequality in the patient prioritization for liver transplantation. (2) Methods: We calculated female-as-male MELD scores in our cohort by substituting the serum creatinine of a female patient with that of their male equivalent to test for the fairness of the scores. We investigated the effects of the female-as-male scores compared to the original MELD score of 1759 patients listed for liver transplantation. (3) Results: Serum creatinine sex correction (female-as-male) for MELD scores added up to 5.4 points in females, while the median changed by +1.6 points for females. We identified 72 females with an original MELD score < 20, for whom the adjusted female-as-male MELD score would be >20, thus giving them a better chance to receive a liver transplant. (4) Conclusions: Mathematical conversion of female to male creatinine concentrations identified disadvantages in liver transplantation prioritization for females and ascertained MELD 3.0 as having high potential to compensate for these inequalities.
Erscheinungsjahr
2023
Zeitschriftentitel
Journal of Personalized Medicine
Band
13
Ausgabe
6
Art.-Nr.
963
eISSN
2075-4426
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2979856

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Walter Costa MB, Gärtner C, Schmidt M, Berg T, Seehofer D, Kaiser T. Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort. Journal of Personalized Medicine. 2023;13(6): 963.
Walter Costa, M. B., Gärtner, C., Schmidt, M., Berg, T., Seehofer, D., & Kaiser, T. (2023). Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort. Journal of Personalized Medicine, 13(6), 963. https://doi.org/10.3390/jpm13060963
Walter Costa, Maria Beatriz, Gärtner, Christiane, Schmidt, Maria, Berg, Thomas, Seehofer, Daniel, and Kaiser, Thorsten. 2023. “Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort”. Journal of Personalized Medicine 13 (6): 963.
Walter Costa, M. B., Gärtner, C., Schmidt, M., Berg, T., Seehofer, D., and Kaiser, T. (2023). Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort. Journal of Personalized Medicine 13:963.
Walter Costa, M.B., et al., 2023. Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort. Journal of Personalized Medicine, 13(6): 963.
M.B. Walter Costa, et al., “Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort”, Journal of Personalized Medicine, vol. 13, 2023, : 963.
Walter Costa, M.B., Gärtner, C., Schmidt, M., Berg, T., Seehofer, D., Kaiser, T.: Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort. Journal of Personalized Medicine. 13, : 963 (2023).
Walter Costa, Maria Beatriz, Gärtner, Christiane, Schmidt, Maria, Berg, Thomas, Seehofer, Daniel, and Kaiser, Thorsten. “Revising the MELD Score to Address Sex-Bias in Liver Transplant Prioritization for a German Cohort”. Journal of Personalized Medicine 13.6 (2023): 963.
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2023-06-12T06:26:33Z
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