Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

Hoffmann, Arne; Schülke, Kai Hannes; Hammer, Stephan; Rentmeister, Andrea; Cornelissen, Nicolas V.

Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

Hoffmann A, Schülke KH, Hammer S, Rentmeister A, Cornelissen NV (2023)
Chemical Communications 59(36): 5463-5466.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.1039/D3CC01036H

Autor*in

Hoffmann, Arne; Schülke, Kai Hannes^UniBi; Hammer, Stephan^UniBi ; Rentmeister, Andrea; Cornelissen, Nicolas V.

Einrichtung

Fakultät für Chemie > Organische Chemie und Biokatalyse
Centrum für Biotechnologie > Arbeitsgruppe S. Hammer

Projekt

Emmy Noether Phase 1: New catalytic reaction development by laboratory evolution of protein-based catalysts (Emmy Noether Research Group Phase 1)
Emmy Noether Phase 2: New catalytic reaction development by laboratory evolution of protein-based catalysts (Emmy Noether Research Group Phase 2)
DBU PhD Kai Schülke: Deutsche Bundesstiftung Umwelt: Erweiterte Cosubstrat-Biochemie: Enzymatische Synthese und Rezyklierung von SAM-Analoga für hochselektive Alkylierungschemie (Sachmittel Kai Schülke)

Abstract / Bemerkung

Comparison ofS-adenosyl-l-methionine (SAM) analogue generation by halide methyltransferase (HMT) and methionine adenosyltransferase (MAT) for methyltransferase catalysed alkylation.

Methyltransferases provide excellent specificity in late-stage alkylation of biomolecules. Their dependence onS-adenosyl-l-methionine (SAM) mandates efficient access to SAM analogues for biocatalytic applications. We directly compared halide methyltransferase (HMT) and methionine adenosyltransferase (MAT) to access SAM analogues and explored their utility in cascade reactions with NovO for regioselective, late-stage Friedel-Crafts alkylation of a coumarin. The HMT cascade efficiently provided SAM for methylation, while the MAT cascade also supplied high levels of SAM analogues for alkylation reactions.

Erscheinungsjahr

2023

Zeitschriftentitel

Chemical Communications

Band

Ausgabe

Seite(n)

5463-5466

ISSN

1359-7345

eISSN

1364-548X

Page URI

https://pub.uni-bielefeld.de/record/2978251

Zitieren

Hoffmann A, Schülke KH, Hammer S, Rentmeister A, Cornelissen NV. Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications. 2023;59(36):5463-5466.

Hoffmann, A., Schülke, K. H., Hammer, S., Rentmeister, A., & Cornelissen, N. V. (2023). Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications, 59(36), 5463-5466. https://doi.org/10.1039/D3CC01036H

Hoffmann, Arne, Schülke, Kai Hannes, Hammer, Stephan, Rentmeister, Andrea, and Cornelissen, Nicolas V. 2023. “Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation”. Chemical Communications 59 (36): 5463-5466.

Hoffmann, A., Schülke, K. H., Hammer, S., Rentmeister, A., and Cornelissen, N. V. (2023). Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications 59, 5463-5466.

Hoffmann, A., et al., 2023. Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications, 59(36), p 5463-5466.

A. Hoffmann, et al., “Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation”, Chemical Communications, vol. 59, 2023, pp. 5463-5466.

Hoffmann, A., Schülke, K.H., Hammer, S., Rentmeister, A., Cornelissen, N.V.: Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications. 59, 5463-5466 (2023).

Hoffmann, Arne, Schülke, Kai Hannes, Hammer, Stephan, Rentmeister, Andrea, and Cornelissen, Nicolas V. “Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation”. Chemical Communications 59.36 (2023): 5463-5466.

Daten bereitgestellt von European Bioinformatics Institute (EBI)