Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation
Hoffmann A, Schülke KH, Hammer S, Rentmeister A, Cornelissen NV (2023)
Chemical Communications.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Hoffmann, Arne;
Schülke, Kai HannesUniBi;
Hammer, StephanUniBi 
;
Rentmeister, Andrea;
Cornelissen, Nicolas V.
;
Rentmeister, Andrea;
Cornelissen, Nicolas V.Einrichtung
Abstract / Bemerkung
Comparison ofS-adenosyl-l -methionine (SAM) analogue generation by halide methyltransferase (HMT) and methionine adenosyltransferase (MAT) for methyltransferase catalysed alkylation.
Methyltransferases provide excellent specificity in late-stage alkylation of biomolecules. Their dependence onS-adenosyl-l -methionine (SAM) mandates efficient access to SAM analogues for biocatalytic applications. We directly compared halide methyltransferase (HMT) and methionine adenosyltransferase (MAT) to access SAM analogues and explored their utility in cascade reactions with NovO for regioselective, late-stage Friedel-Crafts alkylation of a coumarin. The HMT cascade efficiently provided SAM for methylation, while the MAT cascade also supplied high levels of SAM analogues for alkylation reactions.
Methyltransferases provide excellent specificity in late-stage alkylation of biomolecules. Their dependence onS-adenosyl-
Erscheinungsjahr
2023
Zeitschriftentitel
Chemical Communications
ISSN
1359-7345
eISSN
1364-548X
Page URI
https://pub.uni-bielefeld.de/record/2978251
Zitieren
Hoffmann A, Schülke KH, Hammer S, Rentmeister A, Cornelissen NV. Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications. 2023.
Hoffmann, A., Schülke, K. H., Hammer, S., Rentmeister, A., & Cornelissen, N. V. (2023). Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications. https://doi.org/10.1039/D3CC01036H
Hoffmann, Arne, Schülke, Kai Hannes, Hammer, Stephan, Rentmeister, Andrea, and Cornelissen, Nicolas V. 2023. “Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation”. Chemical Communications.
Hoffmann, A., Schülke, K. H., Hammer, S., Rentmeister, A., and Cornelissen, N. V. (2023). Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications.
Hoffmann, A., et al., 2023. Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications.
A. Hoffmann, et al., “Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation”, Chemical Communications, 2023.
Hoffmann, A., Schülke, K.H., Hammer, S., Rentmeister, A., Cornelissen, N.V.: Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation. Chemical Communications. (2023).
Hoffmann, Arne, Schülke, Kai Hannes, Hammer, Stephan, Rentmeister, Andrea, and Cornelissen, Nicolas V. “Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation”. Chemical Communications (2023).
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 37070635
PubMed | Europe PMC
Suchen in
Google Scholar