Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev
Nangmou Nkouayeb BM, Maza Djomkam HL, Tabekoueng GB, Dongmo Tekapi Tsopgni W, Mbahbou Bitchagno GT, Mbock MA, Gounoue Kamkumo R, Frese M, Ndjakou Lenta B, Ngouela SA, Sewald N, et al. (2023)
Chemistry & Biodiversity : e202200271.
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Autor*in
Nangmou Nkouayeb, Brice Maxime;
Maza Djomkam, Hermine Laure;
Tabekoueng, Georges Bellier;
Dongmo Tekapi Tsopgni, Willifred;
Mbahbou Bitchagno, Gabin Thierry;
Mbock, Michel Arnaud;
Gounoue Kamkumo, Raceline;
Frese, MarcelUniBi 
;
Ndjakou Lenta, Bruno;
Ngouela, Silvere Augustin;
Sewald, NorbertUniBi ;
Azebaze, Anatole Guy Blaise
Alle
;
Ndjakou Lenta, Bruno;
Ngouela, Silvere Augustin;
Sewald, NorbertUniBi ;
Azebaze, Anatole Guy Blaise
Alle
Einrichtung
Abstract / Bemerkung
The root extract of Nauclea xanthoxylon (A.Chev.) Aubrev. displayed significant 50% inhibition concentration (IC50s) of 0.57 and 1.26 g/mL against chloroquine resistant and sensitive Plasmodium falciparum (Pf) Dd2 and 3D7 strains, respectively. Bio-guided fractionation led to an ethyl acetate fraction with IC50s of 2.68 and 1.85 g/mL and subsequently, to the new quinovic acid saponin named xanthoxyloside (1) with IC50s of 0.33 and 1.30 M, respectively against the tested strains. Further compounds obtained from ethyl acetate and hexane fractions were the known clethric acid (2), ursolic acid (3), quafrinoic acid (4), quinovic acid (5), quinovic acid 3-O-beta-D-fucopyranoside (6), oleanolic acid (7), oleanolic acid 3-acetate (8), friedelin (9), beta-sitosterol (10a), stigmasterol (10b) and stigmasterol 3-O-beta-D-glucopyranoside (11). Their structures were characterised with the aid of comprehensive spectroscopic methods (1 and 2D NMR, Mass). Bio-assays were performed using nucleic acid gel stain (SYBR green I)-based fluorescence assay with chloroquine as reference. Extracts and compounds exhibited good selectivity indices (SIs) of ˃10. Significant antiplasmodial activities measured for the crude extract, the ethyl acetate fraction and xanthoxyloside (1) from that fraction can justify the use of the root of N. xanthoxylon in ethnomedicine to treat malaria. © 2023 Wiley-VCH GmbH.
Erscheinungsjahr
2023
Zeitschriftentitel
Chemistry & Biodiversity
Art.-Nr.
e202200271
eISSN
1612-1880
Page URI
https://pub.uni-bielefeld.de/record/2969703
Zitieren
Nangmou Nkouayeb BM, Maza Djomkam HL, Tabekoueng GB, et al. Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev. Chemistry & Biodiversity . 2023: e202200271.
Nangmou Nkouayeb, B. M., Maza Djomkam, H. L., Tabekoueng, G. B., Dongmo Tekapi Tsopgni, W., Mbahbou Bitchagno, G. T., Mbock, M. A., Gounoue Kamkumo, R., et al. (2023). Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev. Chemistry & Biodiversity , e202200271. https://doi.org/10.1002/cbdv.202200271
Nangmou Nkouayeb, Brice Maxime, Maza Djomkam, Hermine Laure, Tabekoueng, Georges Bellier, Dongmo Tekapi Tsopgni, Willifred, Mbahbou Bitchagno, Gabin Thierry, Mbock, Michel Arnaud, Gounoue Kamkumo, Raceline, et al. 2023. “Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev”. Chemistry & Biodiversity : e202200271.
Nangmou Nkouayeb, B. M., Maza Djomkam, H. L., Tabekoueng, G. B., Dongmo Tekapi Tsopgni, W., Mbahbou Bitchagno, G. T., Mbock, M. A., Gounoue Kamkumo, R., Frese, M., Ndjakou Lenta, B., Ngouela, S. A., et al. (2023). Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev. Chemistry & Biodiversity :e202200271.
Nangmou Nkouayeb, B.M., et al., 2023. Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev. Chemistry & Biodiversity , : e202200271.
B.M. Nangmou Nkouayeb, et al., “Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev”, Chemistry & Biodiversity , 2023, : e202200271.
Nangmou Nkouayeb, B.M., Maza Djomkam, H.L., Tabekoueng, G.B., Dongmo Tekapi Tsopgni, W., Mbahbou Bitchagno, G.T., Mbock, M.A., Gounoue Kamkumo, R., Frese, M., Ndjakou Lenta, B., Ngouela, S.A., Sewald, N., Azebaze, A.G.B.: Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev. Chemistry & Biodiversity . : e202200271 (2023).
Nangmou Nkouayeb, Brice Maxime, Maza Djomkam, Hermine Laure, Tabekoueng, Georges Bellier, Dongmo Tekapi Tsopgni, Willifred, Mbahbou Bitchagno, Gabin Thierry, Mbock, Michel Arnaud, Gounoue Kamkumo, Raceline, Frese, Marcel, Ndjakou Lenta, Bruno, Ngouela, Silvere Augustin, Sewald, Norbert, and Azebaze, Anatole Guy Blaise. “Bioguided fractionation and isolation of an antiplasmodial saponin from the roots of Nauclea xanthoxylon (A.Chev.) Aubrev”. Chemistry & Biodiversity (2023): e202200271.
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