Association of Clinical Response Criteria and Disease Activity Levels With Physical Function and HRQoL in Patients With Active Axial Spondyloarthritis: 16-Week Results From Two Phase 3 Randomised, Placebo-Controlled Studies
Magrey M, Deodhar A, Mease PJ, Navarro-Compan V, Ramiro S, Rudwaleit M, de la Loge C, Fleurinck C, Taieb V, Morup MF, Oortgiesen M, et al. (2022)
In: ISPOR Europe 2022 Abstracts. Value in Health, 25(12, Suppl.). New York: Elsevier : S427-S428.
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| Veröffentlicht | Englisch
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Autor*in
Magrey, M.;
Deodhar, A.;
Mease, P. J.;
Navarro-Compan, V;
Ramiro, S.;
Rudwaleit, MartinUniBi;
de la Loge, C.;
Fleurinck, C.;
Taieb, V;
Morup, M. F.;
Oortgiesen, M.;
Kay, J.
Einrichtung
Abstract / Bemerkung
Objectives
To examine the association of clinical response criteria and disease activity levels with changes in physical function and health-related quality of life (HRQoL) in patients with axial spondyloarthritis (axSpA).
Methods
This post hoc analysis reports results from the phase 3 studies, BE MOBILE-1 (NCT03928704; non-radiographic axSpA [nr-axSpA]) and BE MOBILE-2 (NCT03928743; ankylosing spondylitis [AS]). All patients reaching specified clinical response criteria (ASAS: 20% improvement from baseline not reached [3.5, ≥2.1–≤3.5, ≥1.3–<2.1, <1.3) at Week
Results
The majority of patients completed Wk16 (nr-axSpA: 244/254 [96.1%]; AS: 322/332 [97.0%]). Baseline BASFI, ASQoL, EQ-5D-3L and SF-36 PCS scores were comparable across studies. Patients achieving higher ASAS response levels demonstrated sequentially greater mean (95% CI) improvements from baseline in BASFI score (nr-axSpA:
Erscheinungsjahr
2022
Titel des Konferenzbandes
ISPOR Europe 2022 Abstracts
Serien- oder Zeitschriftentitel
Value in Health
Band
25
Ausgabe
12, Suppl.
Seite(n)
S427-S428
Konferenz
ISPOR Europe 2022
Konferenzort
Vienna, Austria
Konferenzdatum
2022-09-06 – 2022-09-09
ISSN
1098-3015
eISSN
1524-4733
Page URI
https://pub.uni-bielefeld.de/record/2969537
Zitieren
Magrey M, Deodhar A, Mease PJ, et al. Association of Clinical Response Criteria and Disease Activity Levels With Physical Function and HRQoL in Patients With Active Axial Spondyloarthritis: 16-Week Results From Two Phase 3 Randomised, Placebo-Controlled Studies. In: ISPOR Europe 2022 Abstracts. Value in Health. Vol 25. New York: Elsevier ; 2022: S427-S428.
Magrey, M., Deodhar, A., Mease, P. J., Navarro-Compan, V., Ramiro, S., Rudwaleit, M., de la Loge, C., et al. (2022). Association of Clinical Response Criteria and Disease Activity Levels With Physical Function and HRQoL in Patients With Active Axial Spondyloarthritis: 16-Week Results From Two Phase 3 Randomised, Placebo-Controlled Studies. ISPOR Europe 2022 Abstracts, Value in Health, 25, S427-S428. New York: Elsevier . https://doi.org/10.1016/j.jval.2022.09.2129
Magrey, M., Deodhar, A., Mease, P. J., Navarro-Compan, V, Ramiro, S., Rudwaleit, Martin, de la Loge, C., et al. 2022. “Association of Clinical Response Criteria and Disease Activity Levels With Physical Function and HRQoL in Patients With Active Axial Spondyloarthritis: 16-Week Results From Two Phase 3 Randomised, Placebo-Controlled Studies”. In ISPOR Europe 2022 Abstracts, 25:S427-S428. Value in Health. New York: Elsevier .
Magrey, M., Deodhar, A., Mease, P. J., Navarro-Compan, V., Ramiro, S., Rudwaleit, M., de la Loge, C., Fleurinck, C., Taieb, V., Morup, M. F., et al. (2022). “Association of Clinical Response Criteria and Disease Activity Levels With Physical Function and HRQoL in Patients With Active Axial Spondyloarthritis: 16-Week Results From Two Phase 3 Randomised, Placebo-Controlled Studies” in ISPOR Europe 2022 Abstracts Value in Health, vol. 25, (New York: Elsevier ), S427-S428.
Magrey, M., et al., 2022. Association of Clinical Response Criteria and Disease Activity Levels With Physical Function and HRQoL in Patients With Active Axial Spondyloarthritis: 16-Week Results From Two Phase 3 Randomised, Placebo-Controlled Studies. In ISPOR Europe 2022 Abstracts. Value in Health. no.25 New York: Elsevier , pp. S427-S428.
M. Magrey, et al., “Association of Clinical Response Criteria and Disease Activity Levels With Physical Function and HRQoL in Patients With Active Axial Spondyloarthritis: 16-Week Results From Two Phase 3 Randomised, Placebo-Controlled Studies”, ISPOR Europe 2022 Abstracts, Value in Health, vol. 25, New York: Elsevier , 2022, pp.S427-S428.
Magrey, M., Deodhar, A., Mease, P.J., Navarro-Compan, V., Ramiro, S., Rudwaleit, M., de la Loge, C., Fleurinck, C., Taieb, V., Morup, M.F., Oortgiesen, M., Kay, J.: Association of Clinical Response Criteria and Disease Activity Levels With Physical Function and HRQoL in Patients With Active Axial Spondyloarthritis: 16-Week Results From Two Phase 3 Randomised, Placebo-Controlled Studies. ISPOR Europe 2022 Abstracts. Value in Health. 25, p. S427-S428. Elsevier , New York (2022).
Magrey, M., Deodhar, A., Mease, P. J., Navarro-Compan, V, Ramiro, S., Rudwaleit, Martin, de la Loge, C., Fleurinck, C., Taieb, V, Morup, M. F., Oortgiesen, M., and Kay, J. “Association of Clinical Response Criteria and Disease Activity Levels With Physical Function and HRQoL in Patients With Active Axial Spondyloarthritis: 16-Week Results From Two Phase 3 Randomised, Placebo-Controlled Studies”. ISPOR Europe 2022 Abstracts. New York: Elsevier , 2022.Vol. 25. Value in Health. S427-S428.
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