Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities

Djoumessi AK, Nono RN, Neumann B, Stammler H-G, Bitchagno GTM, Efange NM, Nkenfou CN, Ayong L, Lenta BN, Sewald N, Nkeng-Efouet-Alango P, et al. (2023)
Metabolites 13(2): 298.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Djoumessi, Arnauld Kenfack; Nono, Raymond Ngansop; Neumann, BeateUniBi; Stammler, Hans-GeorgUniBi; Bitchagno, Gabin Thierry Mbahbou; Efange, Noella Molisa; Nkenfou, Celine Nguefeu; Ayong, Lawrence; Lenta, Bruno Ndjakou; Sewald, NorbertUniBi ; Nkeng-Efouet-Alango, Pépin; Chouna, Jean Rodolphe
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Abstract / Bemerkung
The chemical investigation of the EtOH extract from the stem bark of Trichilia monadelpha (Thonn.) J. J. De Wilde afforded two new limonoids (1 and 2): 24-acetoxy-21,25-dihydroxy-21,23-epoxytirucall-7-en-3-one (1) and (6R)-1-O-deacetylkhayanolide E (2), together with eleven known compounds (3–13), including additional limonoids, flavonoids, triterpenoids, steroids, and fatty acid. Their structures were determined using 1D- and 2D-NMR experiments, ESI mass spectrometry, and single crystal X-ray diffraction analysis. The antibacterial and antiplasmodial activities of the extracts, sub-extracts, fractions, and some of the isolated compounds were evaluated in known pathogenic strains, including Staphylococcus aureus and Plasmodium falciparum. Fraction E (n-Hex/EtOAc 30:70, v/v) showed significant activity against S. aureus ATCC 25923 with a MIC value of 3.90 µg/mL, while one of its constituents (epicatechin (9)) exhibited significant activity with MIC values of 7.80 µg/mL. Interestingly, grandifotane A (6) (IC50 = 1.37 µM) and khayanolide D (5) (IC50 = 1.68 µM) were highly active against the chloroquine-sensitive/sulfadoxine-resistant plasmodium falciparum 3D7 strain, unlike their corresponding plant extract and fractions.
Stichworte
Meliaceae; Trichilia monadelpha; limonoids; antibacterial; antiplasmodia
Erscheinungsjahr
2023
Zeitschriftentitel
Metabolites
Band
13
Ausgabe
2
Art.-Nr.
298
eISSN
2218-1989
Page URI
https://pub.uni-bielefeld.de/record/2969038

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Djoumessi AK, Nono RN, Neumann B, et al. Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities. Metabolites. 2023;13(2): 298.
Djoumessi, A. K., Nono, R. N., Neumann, B., Stammler, H. - G., Bitchagno, G. T. M., Efange, N. M., Nkenfou, C. N., et al. (2023). Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities. Metabolites, 13(2), 298. https://doi.org/10.3390/metabo13020298
Djoumessi, Arnauld Kenfack, Nono, Raymond Ngansop, Neumann, Beate, Stammler, Hans-Georg, Bitchagno, Gabin Thierry Mbahbou, Efange, Noella Molisa, Nkenfou, Celine Nguefeu, et al. 2023. “Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities”. Metabolites 13 (2): 298.
Djoumessi, A. K., Nono, R. N., Neumann, B., Stammler, H. - G., Bitchagno, G. T. M., Efange, N. M., Nkenfou, C. N., Ayong, L., Lenta, B. N., Sewald, N., et al. (2023). Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities. Metabolites 13:298.
Djoumessi, A.K., et al., 2023. Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities. Metabolites, 13(2): 298.
A.K. Djoumessi, et al., “Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities”, Metabolites, vol. 13, 2023, : 298.
Djoumessi, A.K., Nono, R.N., Neumann, B., Stammler, H.-G., Bitchagno, G.T.M., Efange, N.M., Nkenfou, C.N., Ayong, L., Lenta, B.N., Sewald, N., Nkeng-Efouet-Alango, P., Chouna, J.R.: Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities. Metabolites. 13, : 298 (2023).
Djoumessi, Arnauld Kenfack, Nono, Raymond Ngansop, Neumann, Beate, Stammler, Hans-Georg, Bitchagno, Gabin Thierry Mbahbou, Efange, Noella Molisa, Nkenfou, Celine Nguefeu, Ayong, Lawrence, Lenta, Bruno Ndjakou, Sewald, Norbert, Nkeng-Efouet-Alango, Pépin, and Chouna, Jean Rodolphe. “Constituents of the Stem Bark of Trichilia monadelpha (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities”. Metabolites 13.2 (2023): 298.
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