Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses
Wittner J, Schulz SR, Steinmetz TD, Berges J, Hauke M, Channell WM, Cunningham AF, Hauser AE, Hutloff A, Mielenz D, Jäck H-M, et al. (2022)
Mucosal Immunology 15(4): 668-682.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Wittner, JensUniBi ;
Schulz, Sebastian R.;
Steinmetz, Tobit D.;
Berges, Johannes;
Hauke, Manuela;
Channell, William M.;
Cunningham, Adam F.;
Hauser, Anja E.;
Hutloff, Andreas;
Mielenz, Dirk;
Jäck, Hans-Martin;
Schuh, Wolfgang
Abstract / Bemerkung
Krüppel-like factor 2 (KLF2) is a potent regulator of lymphocyte differentiation, activation and migration. However, its functional role in adaptive and humoral immunity remains elusive. Therefore, by using mice with a B cell-specific deletion of KLF2, we investigated plasma cell differentiation and antibody responses. We revealed that the deletion of KLF2 resulted in perturbed IgA plasma cell compartmentalization, characterized by the absence of IgA plasma cells in the bone marrow, their reductions in the spleen, the blood and the lamina propria of the colon and the small intestine, concomitant with their accumulation and retention in mesenteric lymph nodes and Peyer's patches. Most intriguingly, secretory IgA in the intestinal lumen was almost absent, dimeric serum IgA was drastically reduced and antigen-specific IgA responses to soluble Salmonella flagellin were blunted in KLF2-deficient mice. Perturbance of IgA plasma cell localization was caused by deregulation of CCR9, Integrin chains αM, α4, β7, and sphingosine-1-phosphate receptors. Hence, KLF2 not only orchestrates the localization of IgA plasma cells by fine-tuning chemokine receptors and adhesion molecules but also controls IgA responses to Salmonella flagellin.
Erscheinungsjahr
2022
Zeitschriftentitel
Mucosal Immunology
Band
15
Ausgabe
4
Seite(n)
668-682
ISSN
1933-0219
Page URI
https://pub.uni-bielefeld.de/record/2969003
Zitieren
Wittner J, Schulz SR, Steinmetz TD, et al. Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses. Mucosal Immunology. 2022;15(4):668-682.
Wittner, J., Schulz, S. R., Steinmetz, T. D., Berges, J., Hauke, M., Channell, W. M., Cunningham, A. F., et al. (2022). Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses. Mucosal Immunology, 15(4), 668-682. https://doi.org/10.1038/s41385-022-00503-0
Wittner, Jens, Schulz, Sebastian R., Steinmetz, Tobit D., Berges, Johannes, Hauke, Manuela, Channell, William M., Cunningham, Adam F., et al. 2022. “Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses”. Mucosal Immunology 15 (4): 668-682.
Wittner, J., Schulz, S. R., Steinmetz, T. D., Berges, J., Hauke, M., Channell, W. M., Cunningham, A. F., Hauser, A. E., Hutloff, A., Mielenz, D., et al. (2022). Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses. Mucosal Immunology 15, 668-682.
Wittner, J., et al., 2022. Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses. Mucosal Immunology, 15(4), p 668-682.
J. Wittner, et al., “Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses”, Mucosal Immunology, vol. 15, 2022, pp. 668-682.
Wittner, J., Schulz, S.R., Steinmetz, T.D., Berges, J., Hauke, M., Channell, W.M., Cunningham, A.F., Hauser, A.E., Hutloff, A., Mielenz, D., Jäck, H.-M., Schuh, W.: Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses. Mucosal Immunology. 15, 668-682 (2022).
Wittner, Jens, Schulz, Sebastian R., Steinmetz, Tobit D., Berges, Johannes, Hauke, Manuela, Channell, William M., Cunningham, Adam F., Hauser, Anja E., Hutloff, Andreas, Mielenz, Dirk, Jäck, Hans-Martin, and Schuh, Wolfgang. “Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses”. Mucosal Immunology 15.4 (2022): 668-682.
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