In vivo Effects of Terbinafine and Ketoconazole on Testosterone Plasma Levels in Healthy Males

Effendy I, Krause W (1989)
Dermatologica 178(2): 103-106.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Effendy, IsaakUniBi ; Krause, W
Abstract / Bemerkung
Ten healthy male volunteers received daily 200 mg of ketoconazole or 500 mg of terbinafine (SF 86-327) for a period of 8 days according to a crossover double-blind design. Between the periods of treatment there was an interval of 3 weeks. Before and during the treatments, on 3 days in all, blood levels of testosterone were determined in the morning at 08.00 and 12.00 h. On the following day in each case, after taking a basal blood sample, 5,000 IU of hCG were injected intravenously and 2 h later a further blood sample for plasma testosterone determination was taken (short-term hCG stimulation test). Prior to treatment, the mean plasma testosterone levels at 12.00 h were slightly below the level at 08.00 h (6.5 ± 3.5 against 7.2 ± 3.1 ng/ml).The difference increased and was statistically significant with ketoconazole treatment (4.2 ± 3.2 against 7.7 ± 3.0 ng/ml), but did not alter during administration of terbinafine (7.8 ± 4.4 against 6.8 ± 3.0 ng/ml). The administration of testosterone levels by hCG stimulated 25.6% prior to treatment. The stimulation was suppressed to zero by ketoconazole but clearly intensified (41.7%) by terbinafine treatment. The results demonstrate once more the well-known effect of ketoconazole on testosterone production and confirm that terbinafine obviously does not have this effect.
Erscheinungsjahr
1989
Zeitschriftentitel
Dermatologica
Band
178
Ausgabe
2
Seite(n)
103-106
ISSN
0011-9075
Page URI
https://pub.uni-bielefeld.de/record/2968845

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Effendy I, Krause W. In vivo Effects of Terbinafine and Ketoconazole on Testosterone Plasma Levels in Healthy Males. Dermatologica. 1989;178(2):103-106.
Effendy, I., & Krause, W. (1989). In vivo Effects of Terbinafine and Ketoconazole on Testosterone Plasma Levels in Healthy Males. Dermatologica, 178(2), 103-106. https://doi.org/10.1159/000248401
Effendy, Isaak, and Krause, W. 1989. “In vivo Effects of Terbinafine and Ketoconazole on Testosterone Plasma Levels in Healthy Males”. Dermatologica 178 (2): 103-106.
Effendy, I., and Krause, W. (1989). In vivo Effects of Terbinafine and Ketoconazole on Testosterone Plasma Levels in Healthy Males. Dermatologica 178, 103-106.
Effendy, I., & Krause, W., 1989. In vivo Effects of Terbinafine and Ketoconazole on Testosterone Plasma Levels in Healthy Males. Dermatologica, 178(2), p 103-106.
I. Effendy and W. Krause, “In vivo Effects of Terbinafine and Ketoconazole on Testosterone Plasma Levels in Healthy Males”, Dermatologica, vol. 178, 1989, pp. 103-106.
Effendy, I., Krause, W.: In vivo Effects of Terbinafine and Ketoconazole on Testosterone Plasma Levels in Healthy Males. Dermatologica. 178, 103-106 (1989).
Effendy, Isaak, and Krause, W. “In vivo Effects of Terbinafine and Ketoconazole on Testosterone Plasma Levels in Healthy Males”. Dermatologica 178.2 (1989): 103-106.
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