Skin susceptibility to dithranol: contact allergy or irritation?

Löffler H, Effendy I, Happle R (1999)
European Journal of Dermatology 9(1): 32-34.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Löffler, H; Effendy, IsaakUniBi ; Happle, R
Abstract / Bemerkung
A pronounced skin reaction to rather low concentrations of dithranol is often observed. The question arises as to whether this represents an allergic or irritant reaction. We performed patch tests with dithranol ointment in various concentrations on psoriatic patients and healthy volunteers. The results failed to show any clear-cut difference in skin reactions between psoriatic patients and healthy volunteers. One subject with a previously known skin hyperreactivity to dithranol showed a similar response to those of some healthy probands. However, subjects showing a pronounced response to rather low concentrations of dithranol also demonstrated a strong reaction to sodium lauryl sulphate, a standard irritant. We conclude that increased reactivity to dithranol most likely reflects an increased genuine skin susceptibility, rather than an allergic response.
Stichworte
psoriasis; contact dermatitis; patch test; skin irritation; sodium; lauryl sulphate; dithranol
Erscheinungsjahr
1999
Zeitschriftentitel
European Journal of Dermatology
Band
9
Ausgabe
1
Seite(n)
32-34
ISSN
1167-1122
eISSN
1952-4013
Page URI
https://pub.uni-bielefeld.de/record/2968816

Zitieren

Löffler H, Effendy I, Happle R. Skin susceptibility to dithranol: contact allergy or irritation? European Journal of Dermatology. 1999;9(1):32-34.
Löffler, H., Effendy, I., & Happle, R. (1999). Skin susceptibility to dithranol: contact allergy or irritation? European Journal of Dermatology, 9(1), 32-34.
Löffler, H, Effendy, Isaak, and Happle, R. 1999. “Skin susceptibility to dithranol: contact allergy or irritation?”. European Journal of Dermatology 9 (1): 32-34.
Löffler, H., Effendy, I., and Happle, R. (1999). Skin susceptibility to dithranol: contact allergy or irritation? European Journal of Dermatology 9, 32-34.
Löffler, H., Effendy, I., & Happle, R., 1999. Skin susceptibility to dithranol: contact allergy or irritation? European Journal of Dermatology, 9(1), p 32-34.
H. Löffler, I. Effendy, and R. Happle, “Skin susceptibility to dithranol: contact allergy or irritation?”, European Journal of Dermatology, vol. 9, 1999, pp. 32-34.
Löffler, H., Effendy, I., Happle, R.: Skin susceptibility to dithranol: contact allergy or irritation? European Journal of Dermatology. 9, 32-34 (1999).
Löffler, H, Effendy, Isaak, and Happle, R. “Skin susceptibility to dithranol: contact allergy or irritation?”. European Journal of Dermatology 9.1 (1999): 32-34.
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