Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice
Löffler H, Hoffmann R, Happle R, Effendy I (2001)
Clinical and Experimental Dermatology 26(2): 196-200.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Löffler, H;
Hoffmann, R;
Happle, R;
Effendy, IsaakUniBi 
Abstract / Bemerkung
The standard method for evaluating contact allergy in mice is the ear swelling technique. However, in experimental irritant contact dermatitis, the epidermal barrier disruption, that represents a predominant effect of irritants, cannot be assayed by this method. An appropriate method to evaluate barrier disruption is the measurement of transepidermal water loss (TEWL) but to date this has so far been possible only on the trunk of hairless or shaved mice. We therefore developed a new technique to measure the TEWL of mice ears (murine auricular TEWL: MATEWL), After patch testing with irritants and allergens, respectively, we found that the ear swelling method is most suitable for evaluating allergic skin reactions, whereas MATEWL is most appropriate for evaluating irritant skin reactions.
Erscheinungsjahr
2001
Zeitschriftentitel
Clinical and Experimental Dermatology
Band
26
Ausgabe
2
Seite(n)
196-200
ISSN
0307-6938
Page URI
https://pub.uni-bielefeld.de/record/2968808
Zitieren
Löffler H, Hoffmann R, Happle R, Effendy I. Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology . 2001;26(2):196-200.
Löffler, H., Hoffmann, R., Happle, R., & Effendy, I. (2001). Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology , 26(2), 196-200. https://doi.org/10.1046/j.1365-2230.2001.00795.x
Löffler, H, Hoffmann, R, Happle, R, and Effendy, Isaak. 2001. “Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice”. Clinical and Experimental Dermatology 26 (2): 196-200.
Löffler, H., Hoffmann, R., Happle, R., and Effendy, I. (2001). Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology 26, 196-200.
Löffler, H., et al., 2001. Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology , 26(2), p 196-200.
H. Löffler, et al., “Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice”, Clinical and Experimental Dermatology , vol. 26, 2001, pp. 196-200.
Löffler, H., Hoffmann, R., Happle, R., Effendy, I.: Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology . 26, 196-200 (2001).
Löffler, H, Hoffmann, R, Happle, R, and Effendy, Isaak. “Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice”. Clinical and Experimental Dermatology 26.2 (2001): 196-200.
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