Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice

Löffler, H; Hoffmann, R; Happle, R; Effendy, Isaak

Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice

Löffler H, Hoffmann R, Happle R, Effendy I (2001)
Clinical and Experimental Dermatology 26(2): 196-200.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

Download

Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!

DOI

https://doi.org/10.1046/j.1365-2230.2001.00795.x

Autor*in

Löffler, H; Hoffmann, R; Happle, R; Effendy, Isaak^UniBi

Einrichtung

Medizinische Fakultät OWL > Vertretungsprofessur für Dermatologie

Abstract / Bemerkung

The standard method for evaluating contact allergy in mice is the ear swelling technique. However, in experimental irritant contact dermatitis, the epidermal barrier disruption, that represents a predominant effect of irritants, cannot be assayed by this method. An appropriate method to evaluate barrier disruption is the measurement of transepidermal water loss (TEWL) but to date this has so far been possible only on the trunk of hairless or shaved mice. We therefore developed a new technique to measure the TEWL of mice ears (murine auricular TEWL: MATEWL), After patch testing with irritants and allergens, respectively, we found that the ear swelling method is most suitable for evaluating allergic skin reactions, whereas MATEWL is most appropriate for evaluating irritant skin reactions.

Erscheinungsjahr

2001

Zeitschriftentitel

Clinical and Experimental Dermatology

Band

Ausgabe

Seite(n)

196-200

ISSN

0307-6938

Page URI

https://pub.uni-bielefeld.de/record/2968808

Zitieren

Löffler H, Hoffmann R, Happle R, Effendy I. Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology . 2001;26(2):196-200.

Löffler, H., Hoffmann, R., Happle, R., & Effendy, I. (2001). Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology , 26(2), 196-200. https://doi.org/10.1046/j.1365-2230.2001.00795.x

Löffler, H, Hoffmann, R, Happle, R, and Effendy, Isaak. 2001. “Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice”. Clinical and Experimental Dermatology 26 (2): 196-200.

Löffler, H., Hoffmann, R., Happle, R., and Effendy, I. (2001). Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology 26, 196-200.

Löffler, H., et al., 2001. Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology , 26(2), p 196-200.

H. Löffler, et al., “Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice”, Clinical and Experimental Dermatology , vol. 26, 2001, pp. 196-200.

Löffler, H., Hoffmann, R., Happle, R., Effendy, I.: Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice. Clinical and Experimental Dermatology . 26, 196-200 (2001).

Löffler, H, Hoffmann, R, Happle, R, and Effendy, Isaak. “Murine auricular transepidermal water loss - a novel approach for evaluating irritant skin reaction in mice”. Clinical and Experimental Dermatology 26.2 (2001): 196-200.

Daten bereitgestellt von European Bioinformatics Institute (EBI)