Co-expression analysis as tool for the discovery of transport proteins in photorespiration

Bordych C, Eisenhut M, Pick TR, Kuelahoglu C, Weber APM (2013)
Plant Biology 15(4): 686-693.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Bordych, C.; Eisenhut, MarionUniBi ; Pick, T. R.; Kuelahoglu, C.; Weber, A. P. M.
Abstract / Bemerkung
Shedding light on yet uncharacterised components of photorespiration, such as transport processes required for the function of this pathway, is a prerequisite for manipulating photorespiratory fluxes and hence for decreasing photorespiratory energy loss. The ability of forward genetic screens to identify missing links is apparently limited, as indicated by the fact that little progress has been made with this approach during the past decade. The availability of large amounts of gene expression data and the growing power of bioinformatics, paired with availability of computational resources, opens new avenues to discover proteins involved in transport of photorespiratory intermediates. Co-expression analysis is a tool that compares gene expression data under hundreds of different conditions, trying to find groups of genes that show similar expression patterns across many different conditions. Genes encoding proteins that are involved in the same process are expected to be simultaneously expressed in time and space. Thus, co-expression data can aid in the discovery of novel players in a pathway, such as the transport proteins required for facilitating the transfer of intermediates between compartments during photorespiration. We here review the principles of co-expression analysis and show how this tool can be used for identification of candidate genes encoding photorespiratory transporters.
Erscheinungsjahr
2013
Zeitschriftentitel
Plant Biology
Band
15
Ausgabe
4
Seite(n)
686-693
ISSN
1435-8603
Page URI
https://pub.uni-bielefeld.de/record/2968458

Zitieren

Bordych C, Eisenhut M, Pick TR, Kuelahoglu C, Weber APM. Co-expression analysis as tool for the discovery of transport proteins in photorespiration. Plant Biology. 2013;15(4):686-693.
Bordych, C., Eisenhut, M., Pick, T. R., Kuelahoglu, C., & Weber, A. P. M. (2013). Co-expression analysis as tool for the discovery of transport proteins in photorespiration. Plant Biology, 15(4), 686-693. https://doi.org/10.1111/plb.12027
Bordych, C., Eisenhut, Marion, Pick, T. R., Kuelahoglu, C., and Weber, A. P. M. 2013. “Co-expression analysis as tool for the discovery of transport proteins in photorespiration”. Plant Biology 15 (4): 686-693.
Bordych, C., Eisenhut, M., Pick, T. R., Kuelahoglu, C., and Weber, A. P. M. (2013). Co-expression analysis as tool for the discovery of transport proteins in photorespiration. Plant Biology 15, 686-693.
Bordych, C., et al., 2013. Co-expression analysis as tool for the discovery of transport proteins in photorespiration. Plant Biology, 15(4), p 686-693.
C. Bordych, et al., “Co-expression analysis as tool for the discovery of transport proteins in photorespiration”, Plant Biology, vol. 15, 2013, pp. 686-693.
Bordych, C., Eisenhut, M., Pick, T.R., Kuelahoglu, C., Weber, A.P.M.: Co-expression analysis as tool for the discovery of transport proteins in photorespiration. Plant Biology. 15, 686-693 (2013).
Bordych, C., Eisenhut, Marion, Pick, T. R., Kuelahoglu, C., and Weber, A. P. M. “Co-expression analysis as tool for the discovery of transport proteins in photorespiration”. Plant Biology 15.4 (2013): 686-693.
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