Balancing of B Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis

Colinas M, Eisenhut M, Tohge T, Pesquera M, Fernie AR, Weber APM, Fitzpatrick TB (2016)
The Plant Cell 28(2): 439-453.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Colinas, Maite; Eisenhut, MarionUniBi; Tohge, Takayuki; Pesquera, Marta; Fernie, Alisdair R.; Weber, Andreas P.M.; Fitzpatrick, Teresa B.
Abstract / Bemerkung
Vitamin B6 comprises a family of compounds that is essential for all organisms, most notable among which is the cofactor pyridoxal 5′-phosphate (PLP). Other forms of vitamin B6 include pyridoxamine 5′-phosphate (PMP), pyridoxine 5′-phosphate (PNP), and the corresponding nonphosphorylated derivatives. While plants can biosynthesize PLP de novo, they also have salvage pathways that serve to interconvert the different vitamers. The selective contribution of these various pathways to cellular vitamin B6 homeostasis in plants is not fully understood. Although biosynthesis de novo has been extensively characterized, the salvage pathways have received comparatively little attention in plants. Here, we show that the PMP/PNP oxidase PDX3 is essential for balancing B6 vitamer levels in Arabidopsis thaliana. In the absence of PDX3, growth and development are impaired and the metabolite profile is altered. Surprisingly, RNA sequencing reveals strong induction of stress-related genes in pdx3, particularly those associated with biotic stress that coincides with an increase in salicylic acid levels. Intriguingly, exogenous ammonium rescues the growth and developmental phenotype in line with a severe reduction in nitrate reductase activity that may be due to the overaccumulation of PMP in pdx3. Our analyses demonstrate an important link between vitamin B6 homeostasis and nitrogen metabolism.
Erscheinungsjahr
2016
Zeitschriftentitel
The Plant Cell
Band
28
Ausgabe
2
Seite(n)
439-453
ISSN
1040-4651
eISSN
1532-298X
Page URI
https://pub.uni-bielefeld.de/record/2968454

Zitieren

Colinas M, Eisenhut M, Tohge T, et al. Balancing of B Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis. The Plant Cell. 2016;28(2):439-453.
Colinas, M., Eisenhut, M., Tohge, T., Pesquera, M., Fernie, A. R., Weber, A. P. M., & Fitzpatrick, T. B. (2016). Balancing of B Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis. The Plant Cell, 28(2), 439-453. https://doi.org/10.1105/tpc.15.01033
Colinas, Maite, Eisenhut, Marion, Tohge, Takayuki, Pesquera, Marta, Fernie, Alisdair R., Weber, Andreas P.M., and Fitzpatrick, Teresa B. 2016. “Balancing of B Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis”. The Plant Cell 28 (2): 439-453.
Colinas, M., Eisenhut, M., Tohge, T., Pesquera, M., Fernie, A. R., Weber, A. P. M., and Fitzpatrick, T. B. (2016). Balancing of B Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis. The Plant Cell 28, 439-453.
Colinas, M., et al., 2016. Balancing of B Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis. The Plant Cell, 28(2), p 439-453.
M. Colinas, et al., “Balancing of B Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis”, The Plant Cell, vol. 28, 2016, pp. 439-453.
Colinas, M., Eisenhut, M., Tohge, T., Pesquera, M., Fernie, A.R., Weber, A.P.M., Fitzpatrick, T.B.: Balancing of B Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis. The Plant Cell. 28, 439-453 (2016).
Colinas, Maite, Eisenhut, Marion, Tohge, Takayuki, Pesquera, Marta, Fernie, Alisdair R., Weber, Andreas P.M., and Fitzpatrick, Teresa B. “Balancing of B Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis”. The Plant Cell 28.2 (2016): 439-453.
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