Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin

Hägerbäumer P, Gräbitz-Bräuer F, Annegarn M, Dargel C, Stank TJ, Bizien T, Hellweg T (2023)
Pharmaceutics 15(2): 379.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
In this study, the interplay among the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) as a model membrane, the nonsteroidal anti-inflammatory drug naproxen, and the saponin β-aescin are investigated. The naproxen amount was fixed to 10 mol %, and the saponin amount varies from 0.0 to 1.0 mol%. Both substances are common ingredients in pharmaceutics; therefore, it is important to obtain deeper knowledge of their impact on lipid membranes. The size and properties of the DMPC model membrane upon naproxen and aescin addition were characterized with differential scanning calorimetry (DSC), small- and wide-angle X-ray scattering (SAXS, WAXS), and photon correlation spectroscopy (PCS) in a temperature-dependent study. The interaction of all substances was dependent on the lipid phase state, which itself depends on the lipid’s main phase transition temperature Tm. The incorporation of naproxen and aescin distorted the lipid membrane structure and lowers Tm. Below Tm, the DMPC–naproxen–aescin mixtures showed a vesicle structure, and the insertion of naproxen and aescin influenced neither the lipid chain–chain correlation distance nor the membrane thickness. Above Tm, the insertion of both molecules instead induced the formation of correlated bilayers and a decrease in the chain–chain correlation distance. The presented data clearly confirm the interaction of naproxen and aescin with DMPC model membranes. Moreover, the incorporation of both additives into the model membranes is evidenced.
Stichworte
DMPC; small unilamellar vesicles (SUVs); nonsteroidal anti-inflammatory drug; naproxen; saponin; β-aescin; SAXS; WAXS; DSC; PCS
Erscheinungsjahr
2023
Zeitschriftentitel
Pharmaceutics
Band
15
Ausgabe
2
Art.-Nr.
379
eISSN
1999-4923
Page URI
https://pub.uni-bielefeld.de/record/2968348

Zitieren

Hägerbäumer P, Gräbitz-Bräuer F, Annegarn M, et al. Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin. Pharmaceutics. 2023;15(2): 379.
Hägerbäumer, P., Gräbitz-Bräuer, F., Annegarn, M., Dargel, C., Stank, T. J., Bizien, T., & Hellweg, T. (2023). Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin. Pharmaceutics, 15(2), 379. https://doi.org/10.3390/pharmaceutics15020379
Hägerbäumer, Pia, Gräbitz-Bräuer, Friederike, Annegarn, Marco, Dargel, Carina, Stank, Tim Julian, Bizien, Thomas, and Hellweg, Thomas. 2023. “Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin”. Pharmaceutics 15 (2): 379.
Hägerbäumer, P., Gräbitz-Bräuer, F., Annegarn, M., Dargel, C., Stank, T. J., Bizien, T., and Hellweg, T. (2023). Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin. Pharmaceutics 15:379.
Hägerbäumer, P., et al., 2023. Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin. Pharmaceutics, 15(2): 379.
P. Hägerbäumer, et al., “Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin”, Pharmaceutics, vol. 15, 2023, : 379.
Hägerbäumer, P., Gräbitz-Bräuer, F., Annegarn, M., Dargel, C., Stank, T.J., Bizien, T., Hellweg, T.: Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin. Pharmaceutics. 15, : 379 (2023).
Hägerbäumer, Pia, Gräbitz-Bräuer, Friederike, Annegarn, Marco, Dargel, Carina, Stank, Tim Julian, Bizien, Thomas, and Hellweg, Thomas. “Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin”. Pharmaceutics 15.2 (2023): 379.
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