The Circadian Biology of Heart Failure

El Jamal N, Lordan R, Teegarden SL, Grosser T, FitzGerald G (2023)
Circulation Research 132(2): 223-237.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
El Jamal, Nadim; Lordan, Ronan; Teegarden, Sarah L.; Grosser, TiloUniBi ; FitzGerald, Garret
Abstract / Bemerkung
Driven by autonomous molecular clocks that are synchronized by a master pacemaker in the suprachiasmatic nucleus, cardiac physiology fluctuates in diurnal rhythms that can be partly or entirely circadian. Cardiac contractility, metabolism, and electrophysiology, all have diurnal rhythms, as does the neurohumoral control of cardiac and kidney function. In this review, we discuss the evidence that circadian biology regulates cardiac function, how molecular clocks may relate to the pathogenesis of heart failure, and how chronotherapeutics might be applied in heart failure. Disrupting molecular clocks can lead to heart failure in animal models, and the myocardial response to injury seems to be conditioned by the time of day. Human studies are consistent with these findings, and they implicate the clock and circadian rhythms in the pathogenesis of heart failure. Certain circadian rhythms are maintained in patients with heart failure, a factor that can guide optimal timing of therapy. Pharmacologic and nonpharmacologic manipulation of circadian rhythms and molecular clocks show promise in the prevention and treatment of heart failure.
Erscheinungsjahr
2023
Zeitschriftentitel
Circulation Research
Band
132
Ausgabe
2
Seite(n)
223-237
ISSN
0009-7330
eISSN
1524-4571
Page URI
https://pub.uni-bielefeld.de/record/2968297

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El Jamal N, Lordan R, Teegarden SL, Grosser T, FitzGerald G. The Circadian Biology of Heart Failure. Circulation Research. 2023;132(2):223-237.
El Jamal, N., Lordan, R., Teegarden, S. L., Grosser, T., & FitzGerald, G. (2023). The Circadian Biology of Heart Failure. Circulation Research, 132(2), 223-237. https://doi.org/10.1161/CIRCRESAHA.122.321369
El Jamal, Nadim, Lordan, Ronan, Teegarden, Sarah L., Grosser, Tilo, and FitzGerald, Garret. 2023. “The Circadian Biology of Heart Failure”. Circulation Research 132 (2): 223-237.
El Jamal, N., Lordan, R., Teegarden, S. L., Grosser, T., and FitzGerald, G. (2023). The Circadian Biology of Heart Failure. Circulation Research 132, 223-237.
El Jamal, N., et al., 2023. The Circadian Biology of Heart Failure. Circulation Research, 132(2), p 223-237.
N. El Jamal, et al., “The Circadian Biology of Heart Failure”, Circulation Research, vol. 132, 2023, pp. 223-237.
El Jamal, N., Lordan, R., Teegarden, S.L., Grosser, T., FitzGerald, G.: The Circadian Biology of Heart Failure. Circulation Research. 132, 223-237 (2023).
El Jamal, Nadim, Lordan, Ronan, Teegarden, Sarah L., Grosser, Tilo, and FitzGerald, Garret. “The Circadian Biology of Heart Failure”. Circulation Research 132.2 (2023): 223-237.

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